Increased incidence of age-related macular degeneration in sensorineural hearing loss: A population-based cohort study

Autoři: Chia-Yi Lee aff001;  Hung-Chi Chen aff003;  Pei-Hsuan Wu aff006;  Jessie Chao-Yun Chi aff007;  Chi-Chin Sun aff009;  Jing-Yang Huang aff011;  Hung-Yu Lin aff001;  Shun-Fa Yang aff007
Působiště autorů: Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan aff001;  Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan, Taiwan aff002;  Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan aff003;  Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan aff004;  Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taiwan aff005;  Department of Otolaryngology–Head and Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan aff006;  Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan aff007;  Department of Otorhinolaryngology Head and Neck Surgery, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan aff008;  Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan aff009;  Department of Chinese Medicine, Chang Gung University, Taoyuan City, Taiwan aff010;  Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan aff011;  Department of Optometry, Chung Shan Medical University, Taichung, Taiwan aff012;  Department of Exercise and Health Promotion, Chung Chou University of Science and Technology, Changhua, Taiwan aff013
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article



To evaluate the incidence of age-related macular degeneration (AMD) in patients diagnosed with sensorineural hearing loss (SNHL) via the application of the National Health Insurance Research Database in Taiwan.

Methodology/Principal findings

A retrospective cohort study was conducted. Patients with a diagnosis of SNHL was enrolled in the study group after exclusion and a propensity score matched group without SNHL was served as the control group with a 1:2 ratio. The main outcome was regarded as the emergence of AMD diagnostic codes. Cox proportional hazard regression was applied to analyze the incidence and adjusted hazard ratio (aHR) of AMD in the multivariate model. A total of 15,686 patients with SNHL were included in the study group while another 31,372 non-SNHL patients served as the control group. After a follow-up interval up to 16 years, there were 484 AMD events occurred in the study group and 660 AMD cases in those non-SNHL patients with a significantly higher aHR compared to the control group after adjusting for multiple potential risk factors (aHR: 1.399, 95% CI: 1.244–1.574). Other prominent risk factors for AMD included older age, ischemic heart disease, hyperlipidemia, Alzheimer's disease, liver disease and kidney disease. Besides, a higher cumulative probability of AMD was observed in the study group (log-rank P <0.0001).


The patients with SNHL demonstrated a higher incidence of developing AMD.

Klíčová slova:

Alzheimer's disease – Cancer detection and diagnosis – Deafness – Diagnostic medicine – Kidneys – Liver diseases – Macular degeneration – Medical risk factors


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