Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons

Autoři: Francisco Fanjul aff001;  Antoni Campins aff001;  Javier Asensio aff001;  Gloria Sampériz aff003;  Aina Yañez aff004;  Dora Romaguera aff002;  Miquel Fiol aff002;  Melchor Riera aff001
Působiště autorů: Infectious Diseases Unit, University Hospital Son Espases, Palma de Mallorca, Spain aff001;  Illes Balears Health Research Institute (IdISBa), Palma de Mallorca, Spain aff002;  Infectious Diseases Unit, University Hospital Miguel Servet, Zaragoza, Spain aff003;  Faculty of Nursing and Physiotherapy, Illes Balears University, Palma de Mallorca, Spain aff004;  Physiopathology of Obesity and Nutrition CIBER (CIBER-OBN), Palma de Mallorca, Spain aff005
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article



Interatrial blocks are considered a new important risk factor for atrial fibrillation and cerebrovascular events. Their prevalence and clinical implications have been reported in general population and several subgroups of patients but no data from HIV-infected populations, with a non-negligible prevalence of atrial fibrillation, has been previously reported.


We conducted a cross-sectional study in a previously enrolled cohort of randomly selected middle-aged HIV-infected patients who attended our hospital and were clinically stable.

Patients underwent both a 12-lead rest electrocardiogram and clinical questionnaires while epidemiological, clinical and HIV-related variables were obtained from electronic medical records and interviews with the patients. Electrocardiograms were then analyzed and codified using a standardized form by two trained members of the research team who were blinded to clinical variables.


We obtained electrocardiograms from 204 patients with a mean age of 55.22 years, 39 patients (19.12%) presented an interatrial block, 9 (4.41%) advanced and 30 (14.71%) partial. Patients with interatrial block had a lower nadir lymphocyte CD4 count (124 vs 198 cells, p = 0.02) while advanced interatrial blocks were associated to older age (62.16 vs. 54.95 years, p = 0.046) and hypertension (77.8% vs. 32.3%, p = 0.009). We did not find differences regarding baseline CD4 lymphocyte count or CD4/CD8 lymphocyte ratio. Clinical variables and functional capacity among patients with or without interatrial block were similar.


In a cohort of clinically stable HIV infected patients the prevalence of interatrial blocks, specially advanced, is high and associated to previously known factors (age, hypertension) and novel ones (nadir CD4 lymphocyte count).

Klíčová slova:

Body Mass Index – Cardiovascular diseases – Electrocardiography – Hepatitis C virus – HIV infections – Hypertension – Chronic obstructive pulmonary disease – Medical risk factors


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2019 Číslo 10
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