Can non-pharmacological interventions reduce hospital admissions in people with dementia? A systematic review

Autoři: Richard Packer aff001;  Yoav Ben Shlomo aff002;  Penny Whiting aff002
Působiště autorů: Department of Health Sciences, University of Leicester, Leicester, United Kingdom aff001;  The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West (NIHR CLAHRC West) at University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom aff002;  Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom aff003
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article



People with dementia who are admitted to hospital have worse outcomes than those without dementia. Identifying interventions that could reduce the risk of hospitalisation in people with dementia has the potential to positively impact on lives of people with dementia. This review aimed to investigate whether there are non-pharmacological interventions that successfully reduce hospitalisation risk, length of stay and mortality in people with dementia.


7 electronic databases and trial registries were searched from inception to October 2018. We included randomised controlled trials that evaluated non-pharmacological interventions in out of hospital settings and targeted people with any type of dementia. All stages of the review process were performed by two reviewers. Risk of bias was assessed using the Cochrane Risk of Bias tool. We grouped studies based on intervention: care management, counselling/self-help, enhanced GP services or memory clinics, and physiotherapy or occupational therapy. Data were pooled within intervention categories using random effects meta-analysis.


There was no evidence that any of the intervention categories were associated with reduced hospital admission or mortality. There was very weak evidence to suggest that care management interventions (mean difference, MD, -0.16, 95% CI -0.32, 0.01), physiotherapy/occupational therapy (MD -0.16, 95% CI -0.36, 0.03) and enhanced GP/memory clinics (MD -0.14, 95% CI -0.31, 0.03) were associated with small reductions in hospital stay. There was no evidence for an effect of counselling/self-help interventions on length of hospital stay.


Current evidence from randomised trials suggests no clear benefit or harm associated with any of interventions on risks of hospitalisation, duration of hospitalisation or death. Further research with the primary aim to reduce hospitalisation in people with dementia is required.

Klíčová slova:

Alzheimer's disease – Database searching – Dementia – Geriatrics – Hospitals – Memory – Nurses – Patients


1. Xie J, Brayne C, Matthews FE. Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up. Br Med J. 2008;336(7638):258–62. doi: 10.1136/bmj.39433.616678.25 18187696

2. WHO. Dementia: a public health priority: WHO; 2012. Available from:

3. Guijarro R, San Román CM, Gómez-Huelgas R, Villalobos A, Martín M, Guil M, et al. Impact of dementia on hospitalization. Neuroepidemiology. 2010;35:101–8. doi: 10.1159/000311032 20551696

4. Lehmann J, Michalowsky B, Kaczynski A, Thyrian JR, Schenk NS, Esser A, et al. The Impact of Hospitalization on Readmission, Institutionalization, and Mortality of People with Dementia: A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease. 2018;64(3):735–49. doi: 10.3233/JAD-171128 29966191.

5. Fogg C, Griffiths P, Meredith P, Bridges J. Hospital outcomes of older people with cognitive impairment: An integrative review. International Journal of Geriatric Psychiatry. 2018;33(9):1177–97. doi: 10.1002/gps.4919 131189503. Language: English. Entry Date: In Process. Revision Date: 20180827. Publication Type: journal article. Journal Subset: Biomedical.

6. Mollers T, Stocker H, Wei W, Perna L, Brenner H. Length of hospital stay and dementia: A systematic review of observational studies. International Journal of Geriatric Psychiatry. 2018;27:27. doi: 10.1002/gps.4993 30260050.

7. O’Neill DJ, Kennelly SP, Gallagher PG, Timmons ST. Irish National Audit of Dementia Care. Eur Geriatr Med. 2014;5:S46. doi: 10.1016/S1878-7649(14)70087-7

8. Eska K, Graessel E, Donath C, Schwarzkopf L, Lauterberg J, Holle R. Predictors of institutionalization of dementia patients in mild and moderate stages: a 4-year prospective analysis. Dement Geriatr Cogn Dis Extra. 2013;3:426–45. doi: 10.1159/000355079 24348504

9. Phelan EAD, Anderson K. J., Owens L. A., S. B. A systematic review of intervention studies to prevent hospitalizations of community-dwelling older adults with dementia. Med Care. 2015;53(2):207–13. doi: 10.1097/MLR.0000000000000294 25588136

10. Lleó A, Greenberg SM, Growdon JH. Current pharmacotherapy for Alzheimer's disease. Annu Rev Med. 2006;57:513–33. doi: 10.1146/ 16409164.

11. Bond M, Rogers G, Peters J, Anderson R, Hoyle M, Miners a, et al. The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model. Health Technol Assess. 2012;16:1–470. doi: 10.3310/hta16210 22541366.

12. NICE. NICE Clinical Guidance 42; Dementia: supporting people with dementia and their carers in health and social care. 2006. Available from:

13. Bentley A. Case management and long-term conditions: the evolution of community matrons. Br J Community Nurs. 2014;19(7):340–5. doi: 10.12968/bjcn.2014.19.7.340 25039343. Language: English. Entry Date: 20140708. Revision Date: 20150820. Publication Type: Journal Article.

14. Cammisuli DMD, Bosinelli S., Cipriani F., G. Non-pharmacological interventions for people with Alzheimer's Disease: A critical review of the scientific literature from the last ten years. European Geriatric Medicine. 2016;7(1):57–64. doi: 10.1016/j.eurger.2016.01.002 20160102766.

15. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] [Internet]: The Cochrane Collaboration; 2011. Available from:

16. Moher D, Liberati A, Tetzlaff J, Altman DG, The PG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLOS Medicine. 2009;6(7):e1000097. doi: 10.1371/journal.pmed.1000097 19621072

17. Green S, Higgins P. T, Julian, Alderson P, Clarke M, Mulrow D C, Oxman D A. Chapter 8: Assessing risk of bias in included studies. 2011. In: Cochrane Handbook for Systematic Reviews of Interventions Version 510 [updated March 2011] [Internet]. [3–10]. Available from:

18. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: An update. Contemporary Clinical Trials. 2007;28:105–14. doi: 10.1016/j.cct.2006.04.004 16807131.

19. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Br Med J. 2003;327:557–60. doi: 10.1136/bmj.327.7414.557 12958120.

20. Amjad H, Wong SK, Roth DL, Huang J, Willink A, Black BS, et al. Health Services Utilization in Older Adults with Dementia Receiving Care Coordination: The MIND at Home Trial. Health Serv Res. 2018;53(1):556–79. doi: 10.1111/1475-6773.12647 28083879.

21. Bass DMJ, Maslow K. S., Wilson K., Morgan N. L., McCarthy R. O., Looman C. A., Snow W. J., Kunik A. L., M. E. Impact of the care coordination program "partners in Dementia Care" on veterans' hospital admissions and emergency department visits. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2015;1(1):13–22. doi: 10.1016/j.trci.2015.03.003 29854922.

22. Bellantonio SK, Fortinsky A. M., Kleppinger R. H., Robison A., Gruman J., Kulldorff C., Trella M., P. M. Efficacy of a geriatrics team intervention for residents in dementia-specific assisted living facilities: effect on unanticipated transitions. Journal of the American Geriatrics Society. 2008;56(3):523–8. doi: 10.1111/j.1532-5415.2007.01591.x 18179497.

23. Callahan CMB, Unverzagt M. A., Austrom F. W., Damush M. G., Perkins T. M., Fultz A. J., Hui B. A., Counsell S. L., Hendrie S. R., H. C. Effectiveness of collaborative care for older adults with Alzheimer disease in primary care: a randomized controlled trial. Jama. 2006;295(18):2148–57. doi: 10.1001/jama.295.18.2148 CN-00556177. 16684985

24. Duru OKE, Vassar S. L., Chodosh S. D., Vickrey J., B. G. Cost evaluation of a coordinated care management intervention for dementia. American Journal of Managed Care. 2009;15(8):521–8. 19670955; PubMed Central PMCID: PMCNIHMS150997 PMC2770874.

25. Eloniemi-Sulkava US, Laakkonen M., Pietilä M., Savikko M., Kautiainen N., Tilvis H., Pitkälä R. S., K. H. Family care as collaboration: effectiveness of a multicomponent support program for elderly couples with dementia. Randomized controlled intervention study. Journal of the American Geriatrics Society. 2009;57(12):2200–8. doi: 10.1111/j.1532-5415.2009.02564.x Language: English. Entry Date: 20100205. Revision Date: 20150711. Publication Type: Journal Article. 20121986

26. Engedal K. Day care for demented patients in general nursing homes. Effects on admissions to institutions and mental capacity. Scand J Prim Health Care. 1989;7(3):161–6. CN-00452100. doi: 10.3109/02813438909087234 2511612

27. Graff MJA, Vernooij-Dassen E. M., Dekker M. J., Jonsson J., Thijssen L., Hoefnagels M., Rikkert W. H., M. G. Community occupational therapy for older patients with dementia and their care givers: cost effectiveness study. Bmj. 2008;336(7636):134–8. doi: 10.1136/bmj.39408.481898.BE PubMed Central PMCID: PMC2206302. 18171718

28. Kohler LM-F, Hein C., Fendrich J., Heymann K., Thyrian R., Hoffmann J. R., W. Does an interdisciplinary network improve dementia care? Results from the IDemUck-study. Current Alzheimer Research. 2014;11(6):538–48. doi: 10.2174/1567205011666140618100727 24938504; PubMed Central PMCID: PMC4150489.

29. Laakkonen MLK, Holtta H., Savikko E., Tilvis N., Strandberg R. S., Pitkala T. E., K. H. Effects of Self-Management Groups for People with Dementia and Their Spouses—Randomized Controlled Trial. Journal of the American Geriatrics Society. 2016;64(4):752–60. doi: 10.1111/jgs.14055 27060101.

30. Meeuwsen EM, van der Aa R., Goluke-Willemse G., de Leest G., van Raak B., Scholzel-Dorenbos F., Verheijen C., Verhey D., Visser F., Wolfs M., Adang C., Rikkert E., M. O. Cost-Effectiveness of One Year Dementia Follow-Up Care by Memory Clinics or General Practitioners: Economic Evaluation of a Randomised Controlled Trial. Plos One. 2013;8(11). doi: 10.1371/journal.pone.0079797 WOS:000327543500012. 24282511

31. Michalowsky B, Flessa S, Eichler T, Hertel J, Dreier A, Zwingmann I, et al. Healthcare utilization and costs in primary care patients with dementia: baseline results of the DelpHi-trial. European Journal of Health Economics. 2018;19(1):87–102. doi: 10.1007/s10198-017-0869-7 28160100.

32. Pitkala KHP, Laakkonen M. M., Tilvis M. L., Savikko R. S., Kautiainen N., Strandberg H., T. E. Effects of the Finnish Alzheimer disease exercise trial (FINALEX): a randomized controlled trial. JAMA Internal Medicine. 2013;173(10):894–901. doi: 10.1001/jamainternmed.2013.359 23589097.

33. Schwarzkopf LM, Kunz P., Holle S., Lauterberg R., Marx J., Mehlig P., Wunder H., Leidl S., Donath R., Graessel C., E. Costs of care for dementia patients in community setting: an analysis for mild and moderate disease stage. Value in Health. 2011;14(6):827–35. doi: 10.1016/j.jval.2011.04.005 21914502.

34. Sogaard RS, Waldorff J., Eckermann F. B., Buss A., Phung D. V., Waldemar K. T., G. Early psychosocial intervention in Alzheimer's disease: cost utility evaluation alongside the Danish Alzheimer's Intervention Study (DAISY). BMJ open. 2014;4(1):e004105. doi: 10.1136/bmjopen-2013-004105 24435893.

35. Voigt-Radloff SGv, Leonhart M., Schornstein R., Jessen K., Bohlken F., Metz J., Fellgiebel B., Dodel A., Eschweiler R., Vernooij-Dassen G., Rikkert M., Hull M. O., M. A multicentre RCT on community occupational therapy in Alzheimer's disease: 10 sessions are not better than one consultation. Bmj Open. 2011;1(1). doi: 10.1136/bmjopen-2011-000096 WOS:000208638000042. 22021760

36. Woods RB, Edwards E., Elvish R., Hoare R., Hounsome Z., Keady B., Moniz-Cook J., Orgeta E., Orrell V., Rees M., Russell J., I. REMCARE: reminiscence groups for people with dementia and their family caregivers—effectiveness and cost-effectiveness pragmatic multicentre randomised trial. Health Technology Assessment. 2012;16(50):1–121. doi: 10.3310/hta16480 108082817. Language: English. Entry Date: 20130628. Revision Date: 20150712. Publication Type: Journal Article.

37. Tanner JAB, Johnston B. S., Hess D., Leoutsakos E., Gitlin J. M., Rabins L. N., Lyketsos P. V., Samus C. G., Q. M. A randomized controlled trial of a community-based dementia care coordination intervention: effects of MIND at Home on caregiver outcomes. American Journal of Geriatric Psychiatry. 2015;23(4):391–402. doi: 10.1016/j.jagp.2014.08.002 25260557; PubMed Central PMCID: PMCNIHMS631119 [Available on 04/01/16] PMC4355038 [Available on 04/01/16].

38. Samus QMJ, Black D., Hess B. S., Lyman E., Vavilikolanu C., Pollutra A., Leoutsakos J., Gitlin J. M., Rabins L. N., Lyketsos P. V., C. G. A multidimensional home-based care coordination intervention for elders with memory disorders: the maximizing independence at home (MIND) pilot randomized trial. American Journal of Geriatric Psychiatry. 2014;22(4):398–414. doi: 10.1016/j.jagp.2013.12.175 24502822; PubMed Central PMCID: PMCNIHMS565040 PMC4034346.

39. Morgan RO, Bass DM, Judge KS, Liu CF, Wilson N, Snow AL, et al. A break-even analysis for dementia care collaboration: Partners in Dementia Care. Journal of general internal medicine. 2015;30:804–9. doi: 10.1007/s11606-015-3205-x 25666216.

40. Bass DMJ, Snow K. S., Wilson A. L., Morgan N. L., Maslow R. O., Randazzo K., Moye R., Odenheimer J. A., Archambault G. L., Elbein E., Pirraglia R., Teasdale P., McCarthy T. A., Looman C. A., Kunik W. J., M. E. A controlled trial of Partners in Dementia Care: Veteran outcomes after six and twelve months. Alzheimer's Research and Therapy. 2014;1 6:9. doi: 10.1186/alzrt242 2014159961.

41. Bass DMJ, Snow K. S., Wilson A. L., Morgan N. L., Looman R., McCarthy W. J., Maslow C. A., Moye K., Randazzo J. A., Garcia-Maldonado R., Elbein M., Odenheimer R., Kunik G., M. E. Caregiver outcomes of partners in dementia care: effect of a care coordination program for veterans with dementia and their family members and friends. Journal of the American Geriatrics Society. 2013;61(8):1377–86. doi: 10.1111/jgs.12362 23869899.

42. Partners in Dementia Care: A Telephone Care Consultation Intervention Provided to Veterans in Partnership With Local Alzheimer's Association Chapters (PDC). NCT00291161. Bethesda (MD): National Library of Medicine (US). 2000 Feb 29:; 2006.

43. Care Management for Patients With Alzheimer Disease and Their Family Caregivers. NCT00246896. Bethesda (MD): National Library of Medicine (US). 2000 Feb 29:; 2005.

44. Vickrey BGM, Connor B. S., Pearson K. I., Della Penna M. L., Ganiats R. D., Demonte T. G., Chodosh R. W. Jr., Cui J., Vassar X., Duan S., Lee N., M. The effect of a disease management intervention on quality and outcomes of dementia care: a randomized, controlled trial. Annals of Internal Medicine. 2006;145(10):713–26. doi: 10.7326/0003-4819-145-10-200611210-00004 17116916.

45. Graff MJV-D, Thijssen M. J., Dekker M., Hoefnagels J., Rikkert W. H., M. G. Community based occupational therapy for patients with dementia and their care givers: randomised controlled trial. Br Med J. 2006;333(7580):1196. doi: 10.1136/bmj.39001.688843.BE 17114212; PubMed Central PMCID: PMC1693594.

46. Laakkonen M-LH, Savikko Eeva H., Niina Strandberg, Suominen Timo E., Merja Pitkälä, Kaisu H. Psychosocial group intervention to enhance self-management skills of people with dementia and their caregivers: study protocol for a randomized controlled trial. Trials. 2012;13(1):133–. doi: 10.1186/1745-6215-13-133 104380992. Language: English. Entry Date: 20130809. Revision Date: 20150711. Publication Type: Journal Article.

47. Meeuwsen EJG, Melis P., Adang R. J., Goluke Willemse E. M., Krabbe G. A., De Leest P. F., Van Raak B. J., Scholzel Dorenbos F. H., Visser C. J., Wolfs M. C., Vliek C. A., Olde Rikkert S., M. G. Cost-effectiveness of post-diagnosis treatment in dementia coordinated by multidisciplinary memory clinics in comparison to treatment coordinated by general practitioners: an example of a pragmatic trial. Journal of Nutrition, Health & Aging. 2009;13(3):242–8. 105468708. Language: English. Entry Date: 20091113. Revision Date: 20150711. Publication Type: Journal Article.

48. Meeuwsen EJM, Van Der Aa R. J., Goluke-Willemse G. C., De Leest G. A., Van Raak B. J., Scholzel-Dorenbos F. H., Verheijen C. J., Verhey D. C., Visser F. R., Wolfs M. C., Adang C. A., Olde Rikkert E. M., M. G. Effectiveness of dementia follow-up care by memory clinics or general practitioners: randomised controlled trial. Br Med J. 2012;344:e3086. doi: 10.1136/bmj.e3086 22589500; PubMed Central PMCID: PMC3352696.

49. Comparison of Effectiveness and Costs of Post-diagnosis Treatment in Dementia (AD-Euro). NCT00554047. Bethesda (MD): National Library of Medicine (US). 2000 Feb 29:; 2007.

50. Michalowsky B, Thyrian JR, Wucherer D, Eichler T, Hertel J, Hoffmann W. Effect Of Dementia Care Management On Healthcare Resource Utilization And Cost: One-Year Follow-Up Results Of The Delphi Trial. Alzheimers Dement. 2016;12(7):P255. doi: 10.1016/j.jalz.2016.06.457

51. Thyrian JRF, Dreier T., Bowing A., Angelow G., Lueke A., Teipel S., Flessa S., Grabe S., Freyberger H. J., Hoffmann H. J., W. Life- and person-centred help in Mecklenburg-Western Pomerania, Germany (DelpHi): study protocol for a randomised controlled trial. Trials. 2012:13:56. doi: 10.1186/1745-6215-13-56 22575023.

52. Thyrian JR, Hertel J, Wucherer D, Eichler T, Michalowsky B, Dreier-Wolfgramm A, et al. Effectiveness and Safety of Dementia Care Management in Primary Care: A Randomized Clinical Trial. JAMA Psychiatry. 2017;74(10):996–1004. doi: 10.1001/jamapsychiatry.2017.2124 28746708.

53. Pitkala KHR, Laakkonen M. M., Tilvis M. L., Savikko R. S., Kautiainen N., Strandberg H., T. E. Effectiveness and costs of intensive exercise intervention on Alzheimer's patients-A randomized, controlled trial. European Geriatric Medicine. 2013;4:S8. doi: 10.1016/j.eurger.2013.07.012 71181905.

54. Pitkala KHR, Laakkonen M. M., Tilvis M. L., Kautiainen R. S., Strandberg H., T. E. Exercise rehabilitation on home-dwelling patients with Alzheimer's disease—a randomized, controlled trial. Study protocol. Trials. 2010;11:92. doi: 10.1186/1745-6215-11-92 20925948.

55. Holle RG, Ruckdaschel E., Wunder S., Mehlig S., Marx H., Pirk P., Butzlaff O., Kunz M., Lauterberg S., J. Dementia care initiative in primary practice: study protocol of a cluster randomized trial on dementia management in a general practice setting. BMC Health Services Research. 2009;9:91. doi: 10.1186/1472-6963-9-91 19500383; PubMed Central PMCID: PMC2702286.

56. Donath CG, Grossfeld-Schmitz E., Menn M., Lauterberg P., Wunder J., Marx S., Ruckdaschel P., Mehlig S., Holle H., R. Effects of general practitioner training and family support services on the care of home-dwelling dementia patients—results of a controlled cluster-randomized study. BMC health services research. 2010;10:314. doi: 10.1186/1472-6963-10-314 21087474.

57. Waldorff FBB, Eckermann D. V., Rasmussen A., Keiding M. L., Rishoj N., Siersma S., Sorensen V., Sorensen J., Vogel L. V., Waldemar A., G. Efficacy of psychosocial intervention in patients with mild Alzheimer's disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY). Bmj. 2012;345:e4693. doi: 10.1136/bmj.e4693 22807076; PubMed Central PMCID: PMC3398860.

58. Waldemar GW, Buss F. B., Eckermann D. V., Keiding A., Rishoj N., Siersma S., Sorensen V., Sorensen J., Vogel L. V., A. The Danish Alzheimer Intervention Study: Rationale, Study Design and Baseline Characteristics of the Cohort. Neuroepidemiology. 2011;36(1):52–61. doi: 10.1159/000322942 WOS:000286428000007. 21196773

59. Phung KTT, Waldorff FB, Buss DV, Eckermann A, Keiding N, Rish?j S, et al. A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomised Danish Alzheimer Intervention Study (DAISY). BMJ Open. 2013;3:e003584. doi: 10.1136/bmjopen-2013-003584 24270834

60. Voigt-Radloff S, Graff M, Leonhart R, Schornstein K, Vernooij-Dassen M, Olde-Rikkert M, et al. WHEDA study: Effectiveness of occupational therapy at home for older people with dementia and their caregivers—the design of a pragmatic randomised controlled trial evaluating a Dutch programme in seven German centres. BMC Geriatrics. 2009;9:44. doi: 10.1186/1471-2318-9-44 19799779

61. Woods RTB, Edwards E., Hounsome R. T., Keady B., Moniz-Cook J., Orrell E. D., Russell M., I. T. Reminiscence groups for people with dementia and their family carers: pragmatic eight-centre randomised trial of joint reminiscence and maintenance versus usual treatment: a protocol. Trials. 2009;10:64. doi: 10.1186/1745-6215-10-64 CN-00723020. 19642992

62. Effectiveness and costs of post-diagnosis treatment in dementia coordinatedby multidisciplinary memory clinics in comparison to treatment coordinated by GP's (Project record). Health Technology Assessment Database; 2006.

63. Maximizing Independence at Home (MIND at Home). NCT01283750. Bethesda (MD): National Library of Medicine (US). 2000 Feb 29:; 2008.

64. Quinn TJ, Woods RT, Orrell M, Bruce E, Edwards RT, Hoare Z, et al. REMCARE: Pragmatic Multi-Centre Randomised Trial of Reminiscence Groups for People with Dementia and their Family Carers: Effectiveness and Economic Analysis. Plos One. 2016;11(4). doi: 10.1371/journal.pone.0152843 27093052

65. Öhman H, Savikko NRN, Strandberg TE, Kautiainen H, Raivio MM, Laakkonen ML, et al. Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease – Secondary analyses of a randomized, controlled trial (FINALEX). European Geriatric Medicine. 2017;8(2):153–7. doi: 10.1016/j.eurger.2017.01.004

66. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–98. doi: 10.1016/0022-3956(75)90026-6 1202204.

67. Reilly SM-C, Malouf C., Hoe R., Toot J., Challis S., Orrell D., M. Case management approaches to home support for people with dementia. Cochrane Database Syst Rev. 2015 Jan 5;(1):CD008345. doi: 10.1002/14651858.CD008345.pub2 107769148. Language: English. Entry Date: 20111014. Revision Date: 20150712. Publication Type: Journal Article.

68. LaMantia MA, Stump TE, Messina FC, Miller DK, Callahan CM. Emergency Department Use Among Older Adults With Dementia. Alzheimer disease and associated disorders. 2016;30(1):35–40. doi: 10.1097/WAD.0000000000000118 26523710.

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