Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model


Autoři: Alon Lai aff001;  Lap Ho aff002;  Thomas W. Evashwick-Rogler aff001;  Hironobu Watanabe aff004;  Jonathan Salandra aff005;  Beth A. Winkelstein aff006;  Damien Laudier aff001;  Andrew C. Hecht aff001;  Giulio M. Pasinetti aff002;  James C. Iatridis aff001
Působiště autorů: Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America aff001;  Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America aff002;  James J. Peters Veterans Affairs Medical Center, Bronx, New York, United States of America aff003;  Keiyu Orthopedic Hospital, Tatebayashi, Japan aff004;  Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, United States of America aff005;  Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America aff006
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223435

Souhrn

Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived foods and beverages, and evidence suggests dietary supplementation with select polyphenol preparations can modulate diverse neurological and painful disorders. This study tested whether supplementation with a select standardized Bioactive-Dietary-Polyphenol-Preparation (BDPP) may alleviate pain symptoms associated with IVD degeneration. Painful IVD degeneration was surgically induced in skeletally-mature rats by intradiscal saline injection into three consecutive lumbar IVDs. Injured rats were given normal or BDPP-supplemented drinking water. In-vivo hindpaw mechanical allodynia and IVD height were assessed weekly for 6 weeks following injury. Spinal column, dorsal-root-ganglion (DRG) and serum were collected at 1 and 6 weeks post-operative (post-op) for analyses of IVD-related mechanical and biological pathogenic processes. Dietary BDPP significantly alleviated the typical behavioral sensitivity associated with surgical procedures and IVD degeneration, but did not modulate IVD degeneration nor changes of pro-inflammatory cytokine levels in IVD. Gene expression analyses suggested BDPP might have an immunomodulatory effect in attenuating the expression of pro-inflammatory cytokines in DRGs. This study supports the idea that dietary supplementation with BDPP has potential to alleviate IVD degeneration-related pain, and further investigations are warranted to identify the mechanisms of action of dietary BDPP.

Klíčová slova:

Cytokines – Gene expression – Inflammation – Neurons – Pain sensation – Rats – Surgical and invasive medical procedures – Allodynia


Zdroje

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