Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort

Autoři: Daniela Rohde aff001;  Eva Gaynor aff002;  Margaret Large aff003;  Lisa Mellon aff001;  Kathleen Bennett aff001;  David J. Williams aff004;  Linda Brewer aff004;  Patricia Hall aff003;  Elizabeth Callaly aff005;  Eamon Dolan aff006;  Anne Hickey aff001
Působiště autorů: Division of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland aff001;  Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland aff002;  Clinical Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland aff003;  Geriatric and Stroke Medicine, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland aff004;  Geriatric Medicine, Mater Misericordiae University Hospital, Dublin, Ireland aff005;  Geriatric Medicine, Connolly Hospital, Dublin, Ireland aff006
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article



Control of vascular risk factors is essential for secondary stroke prevention. However, adherence to secondary prevention medications is often suboptimal, and may be affected by cognitive impairment. Few studies to date have examined associations between cognitive impairment and medication adherence post-stroke, and none have considered whether adherence to secondary prevention medications might affect subsequent cognitive function. The aim of this study was to explore prospective associations between cognitive impairment and medication non-adherence post-stroke.


A five-year follow-up of 108 stroke survivors from the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) prospective observational cohort study. Cognitive function was assessed using the Montreal Cognitive Assessment at 6 months, and a neuropsychological test battery at 5 years. Adherence to antihypertensive, antithrombotic and lipid-lowering medications was assessed using prescription refill data.


The prevalence of cognitive impairment at five years was 35.6%. The prevalence of non-adherence ranged from 15.1% for lipid-lowering agents to 30.2% for antithrombotics. There were no statistically significant associations between medication non-adherence in the first year post-stroke and cognitive impairment at 5 years, nor between cognitive impairment at 6 months and non-adherence at 5 years. Stroke survivors with cognitive impairment were significantly more likely to report receiving help with taking medications [OR (95% CI): 4.84 (1.17, 20.07)].


This is the first study to explore the potential impact of non-adherence to secondary prevention medications on cognitive impairment in stroke survivors. Findings highlight the role of family members and caregivers in assisting stroke survivors with medication administration, particularly in the context of deficits in cognitive function. Involving family members and caregivers may be a legitimate and cost-effective strategy to improve medication adherence in stroke survivors.

Klíčová slova:

Antihypertensives – Cardiology – Cognitive impairment – Lipids – Medical risk factors – Medicine and health sciences – Neuropsychological testing – stroke


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