Involution of retinopathy of prematurity and neurodevelopmental outcomes after intravitreal bevacizumab treatment

Autoři: Yu-Shan Chang aff001;  Ying-Tin Chen aff002;  Tso-Ting Lai aff003;  Hung-Chieh Chou aff004;  Chien-Yi Chen aff004;  Wu-Shiun Hsieh aff004;  Chung-May Yang aff003;  Po-Ting Yeh aff003;  Po-Nien Tsao aff004
Působiště autorů: Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan aff001;  Department of Pediatrics, China Medical University Children's Hospital, Taichung, Taiwan aff002;  Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan aff003;  Department of Pediatrics, National Taiwan University Children’s Hospital, Taipei, Taiwan aff004;  The Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan aff005
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article


This single-centered, retrospective cohort study investigated the timing of involution of retinopathy of prematurity (ROP) and retinal vascularization to zone III after intravitreal bevacizumab (IVB) treatment and its possible impacts on postnatal growth and neurodevelopment. Premature infants with birth weight ≤1500 g, born between 2008 to 2014 and diagnosed with ROP were enrolled. All patients with type 1 ROP underwent IVB as 1st line treatment and were recruited as the study group; those with any stage of ROP except type 1 ROP without treatment served as controls. Neurodevelopmental outcomes were assessed using the Bayley Score of Infant Development (BSID) editions II or III. The study group included 35 eyes from 18 patients; the control group included 86 patients. Twenty-three eyes (65.7%) exhibited ROP regression after a single dose of IVB. The majority of plus sign and extraretinal neovascularization regressed within two weeks. The length of time for retinal vascularization to reach zone III was significantly longer in the treatment group compared with the control (mean post-menstruation age 54.5 vs. 47.0 weeks, p<0.001). Long-term follow-up showed no significant differences in body weight and neurodevelopment between the study and control groups up to the 2-year corrected age.

Klíčová slova:

Birth weight – Body weight – Eyes – Infants – Lasers – Neonates – Retina – Retinopathy of prematurity


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