Pneumoproteins are associated with pulmonary function in HIV-infected persons


Autoři: Diane Jeon aff001;  Emily G. Chang aff002;  Maggie McGing aff002;  Marlena Hartman-Filson aff002;  Mathew Sommers aff002;  Eula Lewis aff003;  John R. Balmes aff001;  Daniela Moisi aff006;  Michael M. Lederman aff006;  Kristine A. Madsen aff004;  Prescott G. Woodruff aff007;  Peter W. Hunt aff008;  Laurence Huang aff0020
Působiště autorů: University of California Berkeley-University of California San Francisco Joint Medical Program, Berkeley, California, United States of America aff001;  HIV, ID and Global Medicine Division, Department of Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, California, United States of America aff002;  Department of Anesthesia and Perioperative Care, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, California, United States of America aff003;  School of Public Health, University of California Berkeley, Berkeley, California, United States of America aff004;  Division of Pulmonary and Critical Care Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, California, United States of America aff005;  Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America aff006;  Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America aff007;  Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America aff008
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223263

Souhrn

Background

COPD is a common HIV comorbidity, and HIV-infected individuals have a higher incidence and earlier onset of COPD compared to HIV-uninfected individuals. While the pathogenesis of HIV-associated COPD is largely unknown, chronic inflammation may contribute. Four pneumoproteins known to be markers of lung injury and inflammation have been associated with COPD in HIV-uninfected individuals: PARC/CCL-18, SP-D, CC-16, and sRAGE.

Objective

To determine whether these pneumoproteins are also associated with pulmonary function and COPD Assessment Test (CAT) scores in HIV-infected individuals.

Methods

Associations between plasma pneumoprotein levels and pulmonary function were determined in a cross-sectional study of otherwise healthy HIV-infected individuals enrolled between September 2016 and June 2017. Covariates included HIV-associated (antiretroviral therapy, CD4 count, and viral load) and COPD-associated (smoking and BMI) covariates.

Results

Among 65 participants, 78.5% were male, 50.8% had undetectable viral load, and 76.9% were ever-smokers. Mean post-bronchodilator FEV1/FVC was 0.71, and mean DLco%predicted was 61%. Higher PARC/CCL-18 was associated with lower DLco%predicted and higher CAT score. Higher CC-16 was associated with lower DLco%predicted and lower FVC%predicted.

Conclusions

This exploratory analysis is the first to characterize associations between these four pneumoproteins and pulmonary function in an HIV-infected cohort. Our findings suggest the pathogenesis of HIV-associated COPD may differ from that of non-HIV-associated COPD due to HIV-specific inflammatory changes affecting DLco. PARC/CCL-18 is associated with structural and functional pulmonary abnormalities and may be an important COPD biomarker candidate in HIV infection. Our study is a preliminary step toward finding clinically relevant COPD biomarkers in high-risk populations.

Klíčová slova:

Biomarkers – HIV – Chronic obstructive pulmonary disease – Inflammation – Inflammatory diseases – Pulmonary function – Smoking habits – Viral load


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