Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles


Autoři: Declan J. Ryan aff001;  Jorgen Antonin Wullems aff001;  Georgina Kate Stebbings aff001;  Christopher Ian Morse aff001;  Claire Elizabeth Stewart aff004;  Gladys Leopoldine Onambele-Pearson aff001
Působiště autorů: Musculoskeletal Sciences & Sport Medicine (MSSM) Research Centre, Department of Sport & Exercise Science, Manchester Metropolitan University, Manchester, United Kingdom aff001;  Science, University of Northampton, Northampton, Northamptonshire, United Kingdom aff002;  Musculoskeletal Rehabilitation Research Group, Department of Rehabilitation Sciences, KU Leuven, Leuven, Flanders, Belgium aff003;  Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, Merseyside, United Kingdom aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224223

Souhrn

Background

It has been advocated that older adults should concomitantly spend less time in sedentary behaviour (SB), and engage in sufficient physical activity (PA), to reduce their risk of cardio-metabolic diseases. However, it is not clear what intensity of PA must be done to offset SB engagement.

Aim

Model how cardio-metabolic profiles could change if older adults replaced an hour per day (hr·day-1) of a physical behaviour intensity with 1 hr·day-1 of another physical behaviour of a different intensity.

Methods

Older adults (n = 93, 60–89 years old, 55% female) wore a thigh-mounted triaxial accelerometer for seven consecutive free-living days to estimate mean daily hourly engagement in SB, Standing, Light Intensity PA (LIPA), sporadic moderate to vigorous physical activity (sMVPA, bouts <10 continuous minutes), and 10-minute MVPA (10MVPA, bouts ≥10 continuous minutes. Fasting whole blood concentration of plasma glucose, triglyceride, total cholesterol, and glycated haemoglobin (%), along with serum concentration of lipoprotein lipase (LPL), interleukin-6 (IL-6), and procollagen III N-terminal propeptide (PIIINP) were measured.

Results

Isotemporal Substitution, with covariate adjustment, suggested that: total cholesterol concentration could theoretically decrease when 1 hr·day-1 of SB is replaced with Standing, when 1 hr.day-1 of LIPA is replaced with Standing, and when 1 hr·day-1 of sMVPA is replaced with Standing. Triglyceride concentration theoretically decreased when 1 hr·day-1 of SB, Standing, LIPA, or sMVPA is replaced with 10MVPA. Triglyceride concentration theoretically increases when 1 hr·day-1 of 10MVPA is replaced with SB, Standing, or LIPA. No associations with time reallocation appears to exist for LPL, HbA1c, IL-6, and PIIINP.

Conclusion

The type of physical behaviour being replaced could be crucial for total cholesterol maintenance. Engagement in 10MVPA could be necessary to improve triglyceride concentration.

Klíčová slova:

Accelerometers – Cardiology – Cardiovascular diseases – Elderly – Cholesterol – Lipids – Lipoproteins – Physical activity


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