Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles

Autoři: Declan J. Ryan aff001;  Jorgen Antonin Wullems aff001;  Georgina Kate Stebbings aff001;  Christopher Ian Morse aff001;  Claire Elizabeth Stewart aff004;  Gladys Leopoldine Onambele-Pearson aff001
Působiště autorů: Musculoskeletal Sciences & Sport Medicine (MSSM) Research Centre, Department of Sport & Exercise Science, Manchester Metropolitan University, Manchester, United Kingdom aff001;  Science, University of Northampton, Northampton, Northamptonshire, United Kingdom aff002;  Musculoskeletal Rehabilitation Research Group, Department of Rehabilitation Sciences, KU Leuven, Leuven, Flanders, Belgium aff003;  Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, Merseyside, United Kingdom aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224223



It has been advocated that older adults should concomitantly spend less time in sedentary behaviour (SB), and engage in sufficient physical activity (PA), to reduce their risk of cardio-metabolic diseases. However, it is not clear what intensity of PA must be done to offset SB engagement.


Model how cardio-metabolic profiles could change if older adults replaced an hour per day (hr·day-1) of a physical behaviour intensity with 1 hr·day-1 of another physical behaviour of a different intensity.


Older adults (n = 93, 60–89 years old, 55% female) wore a thigh-mounted triaxial accelerometer for seven consecutive free-living days to estimate mean daily hourly engagement in SB, Standing, Light Intensity PA (LIPA), sporadic moderate to vigorous physical activity (sMVPA, bouts <10 continuous minutes), and 10-minute MVPA (10MVPA, bouts ≥10 continuous minutes. Fasting whole blood concentration of plasma glucose, triglyceride, total cholesterol, and glycated haemoglobin (%), along with serum concentration of lipoprotein lipase (LPL), interleukin-6 (IL-6), and procollagen III N-terminal propeptide (PIIINP) were measured.


Isotemporal Substitution, with covariate adjustment, suggested that: total cholesterol concentration could theoretically decrease when 1 hr·day-1 of SB is replaced with Standing, when 1 of LIPA is replaced with Standing, and when 1 hr·day-1 of sMVPA is replaced with Standing. Triglyceride concentration theoretically decreased when 1 hr·day-1 of SB, Standing, LIPA, or sMVPA is replaced with 10MVPA. Triglyceride concentration theoretically increases when 1 hr·day-1 of 10MVPA is replaced with SB, Standing, or LIPA. No associations with time reallocation appears to exist for LPL, HbA1c, IL-6, and PIIINP.


The type of physical behaviour being replaced could be crucial for total cholesterol maintenance. Engagement in 10MVPA could be necessary to improve triglyceride concentration.

Klíčová slova:

Accelerometers – Cardiology – Cardiovascular diseases – Elderly – Cholesterol – Lipids – Lipoproteins – Physical activity


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2019 Číslo 10