#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Compare HIV/syphilis infections between age groups and explore associated factors of HIV/syphilis co-infections among men who have sex with men in Shenzhen, China, from 2009 to 2017


Autoři: Rong-Xing Weng aff001;  Fu-Chang Hong aff001;  Wei-Ye Yu aff001;  Yu-Mao Cai aff001
Působiště autorů: Department of STD Control and Prevention, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong Province, China aff001
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223377

Souhrn

The aim of this study is to assess the HIV/syphilis epidemic among men who have sex with men (MSM) aged <50 years and ≥50 years in Shenzhen, and explore the associated factors of HIV/syphilis co-infections among MSM in Shenzhen, in order to help prevention and intervention programs determine their target sub-group. A serial cross-sectional study was conducted on MSM in Shenzhen city, China from 2009 to 2017. A questionnaire was used to collect demographic characteristics, history of HIV testing, history of blood donation and sexual behaviors. 5 ml of venous blood were collected for syphilis and HIV tests. The overall prevalence of HIV, syphilis, HIV/syphilis co-infection was 9.40%, 18.97%, and 4.91%, respectively. The prevalence of HIV (15.26%), syphilis (27.71%), HIV/syphilis co-infection (9.24%) in aged ≥50 years MSM was significantly higher than aged <50 years MSM (9.15%, 18.59% and 4.72%, respectively). The following factors were found to be significantly associated with HIV/syphilis co-infections (P<0.05): age≥50 years (OR = 1.78, 95% CI = 1.10–2.87), high school or lower (OR = 1.49, 95% CI = 1.10–2.01), monthly income ≤436.2 USD (OR = 1.74, 95% CI = 1.25–2.42), monthly income 436.4–727.2 USD (OR = 1.46, 95% CI = 1.05–2.03), ≥2 anal sex partners in the past 6 months (OR = 1.59, 95% CI = 1.02–2.49), ≥2 oral sex partners in the past 6 months (OR = 1.60, 95% CI = 1.08–2.36), inconsistent condom use during anal sex in the past 6 months (OR = 1.50, 95% CI = 1.11–2.03). We found that aged <50 years and ≥50 years MSM in Shenzhen had a high prevalence of HIV/syphilis infection in a period from 2009 to 2017. Age-specific sexually transmitted diseases education, prevention, and intervention programs for aged ≥50 years MSM should be implemented urgently and integrated interventions of both HIV and syphilis infections on MSM are needed in the future.

Klíčová slova:

Co-infections – HIV epidemiology – HIV infections – China – Men who have sex with men – Sexually transmitted diseases – Syphilis


Zdroje

1. Rowley J, Vander Hoorn S, Korenromp E, Low N, Unemo M, Abu-Raddad L, et al. Global and Regional Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2016. WHO Bulletin. 2019. Available from: https://www.who.int/bulletin/volumes/97/8/18-228486.pdf?ua = 1

2. Geneva World Health Organization. WHO HIV/AIDS fact sheet.; 2019 July 25 [cited 2 Aug 2019]. Available from: https://journals.plos.org/plosone/s/submission-guidelines#loc-references

3. Wang K, Yan H, Liu Y, Leng Z, Wang B, Zhao J. Increasing prevalence of HIV and syphilis but decreasing rate of self-reported unprotected anal intercourse among men who had sex with men in Harbin, China: results of five consecutive surveys from 2006 to 2010. INT J EPIDEMIOL. 2012;41(2):423. doi: 10.1093/ije/dyr182 22253304

4. Wu Z, Sullivan S, Wang Y, RotheramBorus M, Detels R. Evolution of China's response to HIV/AIDS. The Lancet. 2007;369(9562):679–90.

5. Lu F, Wang N, Wu Z, Sun X, Rehnstrom J, Poundstone K, et al. Estimating the number of people at risk for and living with HIV in China in 2005: methods and results. SEX TRANSM INFECT. 2006;82(Suppl 3):i87.

6. NCAIDS NCC. Update on the AIDS/STD epidemic in China in December 2017. Chin J AIDS STD. 2018;24(2):111. doi: 10.13419/j.cnki.aids.2018.02.01

7. Luo Y, Zhu C, Chen S, Geng Q, Fu R, Li X, et al. Risk factors for HIV and syphilis infection among male sex workers who have sex with men: a cross-sectional study in Hangzhou, China, 2011. BMJ OPEN. 2015;5(4):e6791.

8. Zhou Y, Li D, Lu D, Ruan Y, Qi X, Gao G. Prevalence of HIV and syphilis infection among men who have sex with men in China: a meta-analysis. BIOMED RES INT. 2014;2014(12):620431.

9. Liu Y, Tang HF, Ning Z, Zheng H, He N, Zhang YY. [Co-infections of HIV, syphilis and HSV-2 among men who have sex with men at the voluntary HIV counseling and testing clinics in Shanghai]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38(10):1363–6. doi: 10.3760/cma.j.issn.0254-6450.2017.10.013 29060980

10. Das A, Li J, Zhong F, Ouyang L, Mahapatra T, Tang W, et al. Factors associated with HIV and syphilis co-infection among men who have sex with men in seven Chinese cities. INT J STD AIDS. 2015;26(3):145–55. doi: 10.1177/0956462414531560 24737881

11. Gao W, Li Z, Li Y, Qiao X. Sexual Practices and the Prevalence of HIV and Syphilis among Men Who Have Sex with Men in Lanzhou, China. JPN J INFECT DIS. 2015;68(5):370–5. doi: 10.7883/yoken.JJID.2013.477 25766603

12. Lynn WA, Lightman S. Syphilis and HIV: a dangerous combination. LANCET INFECT DIS. 2004;4(7):456–66. doi: 10.1016/S1473-3099(04)01061-8 15219556

13. Hook ER. Syphilis. LANCET. 2017;389(10078):1550–7. doi: 10.1016/S0140-6736(16)32411-4 27993382

14. Polansky A, Levy I, Mor Z. Risk factors of syphilis co-infection among HIV-infected men who have sex with men in Tel-Aviv, Israel. AIDS CARE. 2019;31(9):1157–61. doi: 10.1080/09540121.2019.1612006 31035774

15. Diaz A, Junquera ML, Esteban V, Martinez B, Pueyo I, Suarez J, et al. HIV/STI co-infection among men who have sex with men in Spain. Euro Surveill. 2009;14(48). doi: 10.2807/ese.14.48.19426-en 20003899

16. Hernandez I, Johnson A, Reina-Ortiz M, Rosas C, Sharma V, Teran S, et al. Syphilis and HIV/Syphilis Co-infection Among Men Who Have Sex With Men (MSM) in Ecuador. AM J MENS HEALTH. 2017;11(4):823–33. doi: 10.1177/1557988316680928 27923971

17. Peng X. China's demographic history and future challenges. SCIENCE. 2011;333(6042):581. doi: 10.1126/science.1209396 21798939

18. Nations U. World Population Ageing 2017 (ST/ESA/SER.A/408). 2017.

19. Zhou Y, Ding Y, Gu K, Lu X, Gao M, He N. Motivations for sexual risk behaviors among older men in Shanghai, China: a qualitative study. BMC PUBLIC HEALTH. 2014;14(1):802.

20. Goodroad BK. HIV and AIDS in People Older Than 50. J GERONTOL NURS. 2003;29(4):18–24. doi: 10.3928/0098-9134-20030401-07 12710355

21. Liu H, Lin X, Xu Y, Chen S, Shi J, Morisky D. Emerging HIV Epidemic Among Older Adults in Nanning, China. AIDS PATIENT CARE ST. 2012;26(10):565.

22. Lindau S, Schumm L, Laumann E, Levinson W, O'Muircheartaigh C, Waite L. A study of sexuality and health among older adults in the United States. NEW ENGL J MED. 2007;357(8):762–74. doi: 10.1056/NEJMoa067423 17715410

23. Huang MB, Ye L, Liang BY, Ning CY, Roth WW, Jiang JJ, et al. Characterizing the HIV/AIDS Epidemic in the United States and China. Int J Environ Res Public Health. 2016;13(1):h13010030.

24. Pearline RV, Tucker JD, Yuan LF, Bu J, Yin YP, Chen XS, et al. Sexually transmitted infections among individuals over fifty years of age in China. Aids Patient Care & Stds. 2010;24(6):345–7.

25. Zhang W, Lu R, Wu G. Analysis of the epidemiological characteristics of HIV/AIDS among older adults in Chongqing. Chongqing Medicine. 2017;46(6):815–7. doi: 10.3969/j.issn.1671–8348.2017.06.030

26. Hei F, Wang L, Qin Q, Ding Z, Wang L. Epidemiological analysis on the characteristics and related factors of HIV/AIDS in 50-year and older Chinese population. Chin J Epidemiol. 2011;32(5):526–7. doi: 10.3760/cma.j.issn.0254-6450.2011.05.025

27. Ning Z, Fu J, Zhuang M, Park JA, Ibragimov U, He N, et al. HIV and syphilis epidemic among MSM and non-MSM aged 50 and above in Shanghai, China: A yearly cross-sectional study, 2008–2014. Glob Public Health. 2018;13(11):1625–1633. doi: 10.1080/17441692.2018.1427271 29419357

28. Shenzhen Statistics Bureau. SHENZHEN STATISTICAL YEARBOOK 2018.: China Statistics Press; 2018.

29. Shenzhen Statistical Bureau. The sixth national census data of Shenzhen in 2010.; 2016.

30. Yang S, Chiu A, Lin Q, Zeng Z, Li Y, Zhang Y, et al. HIV epidemics in Shenzhen and Chongqing, China. PLOS ONE. 2018;13(2):e192849. doi: 10.1371/journal.pone.0192849

31. Cai Y, Song Y, Liu H. Factors associated with syphilis/HIV infection among men who have sex with men in Shenzhen,2011–2016. Zhonghua Yu Fang Yi Xue Za Zhi. 2017;11(51):994–1000. doi: 10.3760/cma.j.issn.0253-9624.2017.11.008

32. Cai Y, Song Y, Hong F. Joinpoint regression analysis on trends of syphilis/HIV prevalence among men who have sex with men in Shenzhen. Chin J AIDS STD. 2017;23(1):33–5.

33. Li YZ, Xu JJ, Qian HZ, You BX, Zhang J, Zhang JM, et al. High prevalence of HIV infection and unprotected anal intercourse among older men who have sex with men in China: a systematic review and meta-analysis. BMC Infect Dis. 2014;14(1):531.

34. Wu Z, Xu J, Liu E, Mao Y, Xiao Y, Sun X, et al. Editor's choice: HIV and Syphilis Prevalence Among Men Who Have Sex With Men: ACross-Sectional Survey of 61 Cities in China. CLIN INFECT DIS. 2013;57(2):298–309. doi: 10.1093/cid/cit210 23580732

35. Xu HL, Jia MH, Min XD, Zhang RZ, Yu CJ, Wang J, et al. Factors influencing HIV infection in men who have sex with men in China. ASIAN J ANDROL. 2013;15(4):545–9. doi: 10.1038/aja.2013.51 23708455

36. Cai AJ, Tian T, Zhang Z, Zhao XL, Ye Y, Li YY, et al. HIV infection and associated factors in men who have sex with men and also with women in Urumqi from 2010 to 2014. Zhonghua Liu Xing Bing Xue Za Zhi. 2016;37(11):1509–13. doi: 10.3760/cma.j.issn.0254-6450.2016.11.015 28057144

37. Merrigan M, Azeez A, Afolabi B, Chabikuli ON, Onyekwena O, Eluwa G, et al. HIV prevalence and risk behaviours among men having sex with men in Nigeria. SEX TRANSM INFECT. 2011;87(1):65–70. doi: 10.1136/sti.2008.034991 20820061

38. Guo Y, Li X, Stanton B. HIV-related behavioral studies of men who have sex with men in China: a systematic review and recommendations for future research. AIDS BEHAV. 2011;15(3):521–34. doi: 10.1007/s10461-010-9808-7 21053064

39. Tao XH, Jiang T, Shao D, Xue W, Ye FS, Wang M, et al. High prevalence of syphilis among street-based female sex workers in Nanchang, China. Indian Dermatol Online J. 2014;5(4):449–55. doi: 10.4103/2229-5178.142491 25396127

40. Zheng C, Xu JJ, Hu QH, Yu YQ, Chu ZX, Zhang J, et al. Commercial sex and risk of HIV, syphilis, and herpes simplex virus-2 among men who have sex with men in six Chinese cities. BMC INFECT DIS. 2016;16(1):765. doi: 10.1186/s12879-016-2130-x 28003032

41. Shan D, Yu MH, Yang J, Zhuang MH, Ning Z, Liu H, et al. Correlates of HIV infection among transgender women in two Chinese cities. INFECT DIS POVERTY. 2018;7(1):123. doi: 10.1186/s40249-018-0508-2 30509315

42. Williams E, Donnelly J. Older Americans and AIDS: some guidelines for prevention. SOC WORK. 2002;47(2):105–11. 12019797

43. La Fleur F. Small. What Older Adults Know about HIV/AIDS: Lessons from an HIV/AIDS Education Program. EDUC GERONTOL. 2009;36(1):26–45.

44. He N. Sociodemographic characteristics, sexual behavior, and HIV risks of rural-to-urban migrants in China. BIOSCI TRENDS. 2007;1(2):72–80. 20103872

45. Zhang X, Zhang T, Pei J, Liu Y, Li X, Medrano-Gracia P. Time Series Modelling of Syphilis Incidence in China from 2005 to 2012. PLOS ONE. 2016;11(2):e149401. doi: 10.1371/journal.pone.0149401 26901682

46. Zhang Y, Chen P, Lu R, Liu L, Wu Y, Liu X, et al. Prevalence of HIV among men who have sex with men in Chongqing, China, 2006–2009: cross-sectional biological and behavioural surveys. SEX TRANSM INFECT. 2012;88(6):444–50. doi: 10.1136/sextrans-2011-050295 22457314

47. Zablotsky D, Kennedy M. Risk factors and HIV transmission to midlife and older women: knowledge, options, and the initiation of safer sexual practices. Journal of Acquired Immune Deficiency Syndromes. 2003;33(2):122–30.

48. Heath J, Lanoye A, Maisto SA. The role of alcohol and substance use in risky sexual behavior among older men who have sex with men: a review and critique of the current literature. Aids & Behavior. 2012;16(3):578–89.

49. Klein H. A comparison of HIV risk practices among unprotected sex-seeking older and younger men who have sex with other men. AGING MALE. 2012;15(3):124–33. doi: 10.3109/13685538.2011.646343 22339079

50. Cao Z, Zhang HB, She M, Wang J, Xu J, Duan YW, et al. [Prevalence of HIV infection and sexual behaviors with both men and women among currently married men who have sex with men]. Zhonghua Liu Xing Bing Xue Za Zhi. 2012;33(5):488–91. 22883175

51. Zhang W, Xu JJ, Zou H, Zhang J, Wang N, Shang H. HIV incidence and associated risk factors in men who have sex with men in Mainland China: an updated systematic review and meta-analysis. SEX HEALTH. 2016. doi: 10.1071/SH16001 27294689

52. Liu L. Prevalence and risk factors of sexually transmitted diseases among MSM infected with HIV: Chinese Center For Disease Control and Prevention; 2017.

53. Hong S, Xu J, Han X, Li JS, Arledge KC, Zhang L. HIV prevention: Bring safe sex to China. NATURE. 2012;485(7400):576–7. doi: 10.1038/485576a 22660303

54. Rositch AF, Cherutich P, Brentlinger P, Kiarie JN, Nduati R, Farquhar C. HIV infection and sexual partnerships and behaviour among adolescent girls in Nairobi, Kenya. INT J STD AIDS. 2012;23(7):468–74. doi: 10.1258/ijsa.2012.011361 22843999

55. Sentis A, Martin-Sanchez M, Arando M, Vall M, Barbera MJ, Ocana I, et al. Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city. BMJ OPEN. 2019;9(5):e27245. doi: 10.1136/bmjopen-2018-027245 31061051

56. Brown MJ, Serovich JM, Kimberly JA, Umasaborbubu O. Disclosure and Self-Efficacy Among HIV-Positive Men Who Have Sex with Men: A Comparison Between Older and Younger Adults. Aids Patient Care & Stds. 2015;29(11):625.

57. Halkitis PN, Kingdon MJ, Barton S, Eddy J. Facilitators and Barriers to HIV Status Disclosure Among HIV-positive MSM Age 50 and Older. Journal of Gay & Lesbian Mental Health. 2016;20(1):41–56.


Článek vyšel v časopise

PLOS One


2019 Číslo 10
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

Svět praktické medicíny 1/2024 (znalostní test z časopisu)
nový kurz

Koncepce osteologické péče pro gynekology a praktické lékaře
Autoři: MUDr. František Šenk

Sekvenční léčba schizofrenie
Autoři: MUDr. Jana Hořínková

Hypertenze a hypercholesterolémie – synergický efekt léčby
Autoři: prof. MUDr. Hana Rosolová, DrSc.

Význam metforminu pro „udržitelnou“ terapii diabetu
Autoři: prof. MUDr. Milan Kvapil, CSc., MBA

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#