Evaluation of ranibizumab and aflibercept for the treatment of diabetic macular edema in daily clinical practice


Autoři: Pablo Plaza-Ramos aff001;  Enrique Borque aff001;  Alfredo García-Layana aff002
Působiště autorů: Ophthalmology Department, Complejo Hospitalario de Navarra, Pamplona, Spain aff001;  Ophthalmology Department, Clínica Universitaria de Navarra, Pamplona, Spain aff002
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223793

Souhrn

Purpose

To evaluate the efficacy and safety of ranibizumab and aflibercept in the treatment of diabetic macular edema in a real world study, and to compare the two treatments with each other.

Methods

Retrospective observational study of 213 eyes from 141 patients with diabetic macular edema was completed between June 2014 and June 2016. 122 were treated with ranibizumab intravitreal injection and 91 with aflibercept intravitreal injection, with a loading phase of 3 injections and a Pro Re Nata protocol. The drug was selected by the physician and fluorescein angiography was performed by physician`s criteria. Re-treatment was performed when a decline in BCVA, an increase of central macular thickness or an increase or persistence of intraretinal fluid in OCT was observed. The primary outcome was the mean change in best corrected visual acuity at 1 year, while central macular thickness, central macular volume, the number of injections and visits were evaluated as secondary outcomes. The correlation between BCVA at 4th month visit and BCVA at 12th month visit was also evaluated.

Results

The mean baseline best corrected visual acuity for the eyes treated with ranibizumab was 0.55 (+/- 0.35) logMAR, and with aflibercept it was 0.48 (+/- 0.29) (P = 0.109). Best corrected visual acuity improved in both groups, and at the end of the follow-up was 0.40 (+/- 0.35) in the ranibizumab group and 0.40 (+/- 0.29) in the aflibercept group (P = 0.864). Best corrected visual acuity at 4th month visit is correlated at a high value (R = 0.789) with the one at the end of the study. No differences were found in central macular thickness, central macular volume and glycosylated hemoglobin when adjusting with baseline values. The overall number of injections was 5.77 (+/- 2.01), being 5.56 (+/- 2.0) in the ranibizumab group and 6.07 (+/- 1.99) in the aflibercept group (P = 0.069). The main outcome determining final best corrected visual acuity was the baseline best corrected visual acuity (P<0.001).

Conclusion

There are no differences in efficacy between ranibizumab and aflibercept in diabetic macular edema treatment in this real world study.

Klíčová slova:

Cataract surgery – Diabetes mellitus – Edema – Eyes – Lasers – Visual acuity – Vascular permeability – Pars plana vitrectomy


Zdroje

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Článek vyšel v časopise

PLOS One


2019 Číslo 10