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Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis


Autoři: Anabella C. Fantilli aff001;  Julieta Trinks aff002;  Sebastián Marciano aff004;  Fabián Zárate aff006;  Domingo C. Balderramo aff007;  Maribel G. Martínez Wassaf aff008;  Leila Haddad aff004;  Adrián Gadano aff004;  José D. Debes aff009;  María B. Pisano aff001;  Viviana E. Ré aff001
Působiště autorů: Instituto de Virología “Dr. J. M. Vanella”, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina aff001;  Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina aff002;  Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)—CONICET—Instituto Universitario del Hospital Italiano (IUHI)—Hospital Italiano (HIBA), Buenos Aires, Argentina aff003;  Sección de Hepatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina aff004;  Departamento de Investigación, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina aff005;  Hospital Córdoba, Córdoba, Argentina aff006;  Departamento de Gastroenterología, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina aff007;  LACE Laboratorios, Córdoba, Argentina aff008;  Department of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America aff009
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0224404

Souhrn

Introduction

Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina.

Materials and methods

We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72).

Results

The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4–15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9–11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8–36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81–11.58); p<0.001].

Conclusion

We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.

Klíčová slova:

Alcohol consumption – Alcohols – Argentina – Cirrhosis – Chronic liver disease – Medical risk factors – Primary biliary cirrhosis – Hepatitis E virus


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