Enriched taxa were found among the gut microbiota of centenarians in East China

Autoři: Na Wang aff001;  Rui Li aff001;  Haijiang Lin aff002;  Chaowei Fu aff001;  Xuecai Wang aff002;  Yiming Zhang aff003;  Meifang Su aff004;  Peixin Huang aff004;  Junhua Qian aff004;  Feng Jiang aff001;  Hexing Wang aff001;  Lufang Jiang aff001;  Xin Yu aff001;  Jianxiang Liu aff001;  Yue Chen aff005;  Qingwu Jiang aff001
Působiště autorů: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China aff001;  Taizhou Center for Disease Control and Prevention, Taizhou City, Jiangsu Province, China aff002;  Deqing Center for Disease Control and Prevention, Deqing City, Zhejiang Province, China aff003;  Yuhuan Center for Disease Control and Prevention, Wenling City, Zhejiang Province, China aff004;  School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada aff005
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222763



Gut microbiota is closely related to age. Studies from Europe and the U.S. identified featured microbiota in different age groups for the elderly. Asian studies mainly focused on people living in longevity areas. Featured microbiota for the elderly people of different age groups, especially in the centenarian in the general population, has not been well investigated in China.


We conducted a comparative study by including 198 subjects of three age groups (65–70, 90–99, and 100+ years) in East China. Information regarding age, sex, height, weight, waist circumference, hip circumference, food preference, smoking status and alcohol consumption were collected by using a structured questionnaire. Fecal samples for each participant were collected as well. 16S rRNA gene sequencing were employed to analyze the gut microbiota composition. Logistic regression with LASSO feature selection was used to identify featured taxa in different age groups and to assess their potential interactions with other factors such as lifestyle.


The gut microbiota of the 90–99 year and 100+ year age groups showed more diversity, robustness, and richness compared with the 65–70 year age group. PCoA analysis showed a clear separation between the 65–70 and 100+ year age groups. At the species level, Bacteroides fragilis, Parabacteroides merdae, Ruminococcus gnavus, Coprococcus and Clostridium perfringens increased, but Bacteroides vulgatus, Ruminococcus sp.5139BFAA and Clostridium sp.AT5 decreased in the 90–99 year age group. The age differences in gut microbiota were similar across the strata of smoking, alcohol consumption status and food preference.


Our study demonstrated age differences in many aspects of gut microbiota, such as overall diversity, microbiota structure, and relative abundance of key taxa. Moreover, the gut microbiota of centenarian was significantly different from those of younger age groups of the elderly.

Klíčová slova:

Age groups – Aging – Alcohol consumption – Elderly – Geriatrics – Gut bacteria – Microbiome – Ruminococcus


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