Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery

Autoři: Mahdieh Abbasalizad Farhangi aff001;  Mahdi Vajdi aff003;  Mahdi Najafi aff004
Působiště autorů: Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran aff001;  Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran aff002;  Student Research Committee, Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran aff003;  Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran aff004;  Faculty Research Associate, Western University, London, ON, Canada aff005;  Cardiac Outcome Research and Education (CORE), Universal Scientific Education and Research Network (USERN), Tehran, Iran aff006
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223830



Numerous studies have revealed the role of dietary acid load as a potential risk factor for cardiovascular events and blood pressure. However, its role in predicting the mortality rate in patients underwent coronary artery bypass grafting surgery (CABG) has not been reported. In the current study we aimed to evaluate the relationship of dietary acid load and cardio-metabolic risk factors with ten year survival among patients underwent CABG.


The current prospective cohort study comprises 454 patients underwent CABG. Anthropometric, clinical and biochemical measurements were performed. Dietary acid load was calculated as either potential renal acid load (PRAL) or net endogenous acid production (NEPA) using the data obtained from a semi-quantitative food frequency questionnaire (FFQ). Survival analysis was performed using Kaplan-Meier method followed by log-rank test. The association between all-cause mortality and study parameters was performed with Cox-proportional hazard model.


Patients in the higher PRAL and NEAP quartiles had lower BMI and lower ejection fraction rate (P <0.05). Moreover, lower hematocrit values were observed in patients of higher PRAL quartiles. Higher PRAL scores were associated with higher mortality rate and reduced survival days (adjusted hazard ratio: 1.023 (1.00–1.04; P-value = 0.01). However, there was no relationship between NEAP and survival.


We revealed that high PRAL scores are positive predictors of 10-year mortality in patients underwent CABG. The results of our study suggest that maintaining an adequate acid-base balance can contribute to longevity by reducing the risk of mortality.

Klíčová slova:

Cardiovascular diseases – Coronary artery bypass grafting – Coronary heart disease – Death rates – Cholesterol – Medical risk factors – Obesity – Surgical and invasive medical procedures


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