The neural substrate of self- and other-concerned wellbeing: An fMRI study

Autoři: HanShin Jo aff001;  Yang-Yen Ou aff003;  Chun-Chia Kung aff001
Působiště autorů: Dept. of Psychology, National Cheng Kung University (NCKU), Tainan, Taiwan aff001;  Inst. Of Medical Informatics, NCKU, Tainan, Taiwan aff002;  Dept. of Electrical Engineering, NCKU, Tainan, Taiwan aff003;  Mind Research and Imaging (MRI) Center, Tainan, Taiwan aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0203974


Happiness, or Subjective Well-Being (SWB), is generally considered as a peaceful and satisfied state accompanied by consistent and optimistic mood. Due to its subjective and elusive nature, however, wellbeing has only been scarcely investigated in the neuroimaging literature. In this study, we investigated its neural substrates by characterizing two different perspectives: self- or other-concerned wellbeing. In the present study, 22 participants evaluated the subjective happiness (with button presses 1 to 4) to 3 categories (intra- and inter-personal and neutral) of pre-rated pictures in a slow event-related fMRI. Because wellbeing is constantly featured by pleasure feelings after self-inspection, we predict that happier conditions, featured by “intra-personal vs. neutral” and “inter-personal vs. neutral” conditions, should yield higher BOLD activities in overlapping reward- and self-related regions. Indeed, medial prefrontal (mPFC), pregenual ACC (pACC), precuneus and posterior cingulate cortex (PCC) were revealed both by General Linear Model (GLM) (categorical contrasts) and parametric modulations (correlations with rating 1-4s), specifically, more connectivity between nucleus accumbens (NAcc) and mPFC, via additional psychophysiological interaction, or PPI, analyses. More interestingly, GLM and multivariate searchlight analyses jointly reveal the subdivision of mPFC and the PCC/precuneus, with anterior mPFC and dorsal PCC/precuneus more for interpersonal, posterior mPFC and ventral PCC/precuneus more for intrapersonal, SWB, respectively. Taken together, these results are not only consistent with the “cortical midline hypothesis of the self”, but also extending the “spatial gradients of self-to-other-concerned processing” from mPFC to including both mPFC and PCC/precuneus, making them two “hubs” of self-to-other-concerned wellbeing network.

Klíčová slova:

Cingulate cortex – Dopamine – Emotions – Functional magnetic resonance imaging – Happiness – Neuroimaging – Nucleus accumbens – Prefrontal cortex


1. Graham MC, Priddy L, Graham S. Facts of Life: ten issues of contentment. Outskirts Press; 2014.

2. Steel P, Schmidt J, Shultz J. Refining the relationship between personality and subjective well-being. Psychol Bull. 2008;134: 138. doi: 10.1037/0033-2909.134.1.138 18193998

3. Argyle M. The psychology of happiness. Routledge; 2013.

4. Oishi S, Graham J, Kesebir S, Galinha IC. Concepts of happiness across time and cultures. Personal Soc Psychol Bull. 2013;39: 559–577.

5. Ryan RM, Deci EL. On happiness and human potentials: A review of research on hedonic and eudaimonic well-being. Annu Rev Psychol. 2001;52: 141–166. doi: 10.1146/annurev.psych.52.1.141 11148302

6. Kim-Prieto C, Diener E, Tamir M, Scollon C, Diener M. Integrating the diverse definitions of happiness: A time-sequential framework of subjective well-being. J Happiness Stud. 2005;6: 261–300.

7. Reis B. The virtuous life in Greek ethics. Cambridge University Press; 2006.

8. Waterman AS. Two conceptions of happiness: Contrasts of personal expressiveness (eudaimonia) and hedonic enjoyment. J Pers Soc Psychol. 1993;64: 678.

9. Dodge R, Daly AP, Huyton J, Sanders LD. The challenge of defining wellbeing. Int J wellbeing. 2012;2.

10. Ryff CD. Happiness is everything, or is it? Explorations on the meaning of psychological well-being. J Pers Soc Psychol. 1989;57: 1069.

11. Ryff CD, Singer BH. Know thyself and become what you are: A eudaimonic approach to psychological well-being. The exploration of happiness. Springer; 2013. pp. 97–116.

12. Chen FF, Jing Y, Hayes A, Lee JM. Two concepts or two approaches? A bifactor analysis of psychological and subjective well-being. J Happiness Stud. 2013;14: 1033–1068.

13. Kesebir P, Diener E. In pursuit of happiness: Empirical answers to philosophical questions. Perspect Psychol Sci. 2008;3: 117–125. doi: 10.1111/j.1745-6916.2008.00069.x 26158878

14. Linley PA, Maltby J, Wood AM, Osborne G, Hurling R. Measuring happiness: The higher order factor structure of subjective and psychological well-being measures. Pers Individ Dif. 2009;47: 878–884.

15. Haller M, Hadler M. How social relations and structures can produce happiness and unhappiness: An international comparative analysis. Soc Indic Res. 2006;75: 169–216.

16. Siedlecki KL, Salthouse TA, Oishi S, Jeswani S. The relationship between social support and subjective well-being across age. Soc Indic Res. 2014;117: 561–576. doi: 10.1007/s11205-013-0361-4 25045200

17. Furnham A, Brewin CR. Personality and happiness. Pers Individ Dif. 1990;11: 1093–1096.

18. Pavot W, Diener ED, Fujita F. Extraversion and happiness. Pers Individ Dif. 1990;11: 1299–1306.

19. Schimmack U, Radhakrishnan P, Oishi S, Dzokoto V, Ahadi S. Culture, personality, and subjective well-being: integrating process models of life satisfaction. J Pers Soc Psychol. 2002;82: 582–593. Available: 11999925

20. Barrett-Cheetham E, Williams LA, Bednall TC. A differentiated approach to the link between positive emotion, motivation, and eudaimonic well-being. J Posit Psychol. 2016;11: 595–608.

21. Dambrun M, Ricard M. Self-centeredness and Selfessness: A theory of self-based psychological functioning and its consequences for hapiness. Rev Gen Psychol. 2011;15: 138.

22. Dambrun M, Desprès G, Lac G. Measuring happiness: from fluctuating happiness to authentic–durable happiness. Front Psychol. 2012;3: 16. doi: 10.3389/fpsyg.2012.00016 22347202

23. Kahneman D. Objective happiness. Well-being Found hedonic Psychol. 1999;3: 25.

24. Rim Y. Values, happiness and family structure variables. Pers Individ Dif. 1993;15: 595–598.

25. Sato W, Kochiyama T, Uono S, Kubota Y, Sawada R, Yoshimura S, et al. The structural neural substrate of subjective happiness. Sci Rep. 2015;5.

26. Luo Y, Qi S, Chen X, You X, Huang X, Yang Z. Pleasure attainment or self-realization: the balance between two forms of well-beings are encoded in default mode network. Soc Cogn Affect Neurosci. 2017;12: 1678–1686. doi: 10.1093/scan/nsx078 28985373

27. Lewis GJ, Kanai R, Rees G, Bates TC. Neural correlates of the ‘good life’: Eudaimonic well-being is associated with insular cortex volume. Soc Cogn Affect Neurosci. 2013;9: 615–618. doi: 10.1093/scan/nst032 23512932

28. Luo Y, Kong F, Qi S, You X, Huang X. Resting-state functional connectivity of the default mode network associated with happiness. Soc Cogn Affect Neurosci. 2015;11: 516–524. doi: 10.1093/scan/nsv132 26500289

29. Pelletier M, Bouthillier A, Lévesque J, Carrier S, Breault C, Paquette V, et al. Separate neural circuits for primary emotions? Brain activity during self-induced sadness and happiness in professional actors. Neuroreport. 2003;14: 1111–1116. doi: 10.1097/00001756-200306110-00003 12821792

30. Rutledge RB, Skandali N, Dayan P, Dolan RJ. Dopaminergic modulation of decision making and subjective well-being. J Neurosci. 2015;35: 9811–9822. doi: 10.1523/JNEUROSCI.0702-15.2015 26156984

31. Kringelbach ML, Berridge KC. Towards a functional neuroanatomy of pleasure and happiness. Trends Cogn Sci. 2009;13: 479–487. doi: 10.1016/j.tics.2009.08.006 19782634

32. Kringelbach ML, Berridge KC. The neuroscience of happiness and pleasure. Soc Res (New York). 2010;77: 659.

33. Kringelbach ML, Berridge KC. The affective core of emotion: linking pleasure, subjective well-being, and optimal metastability in the brain. Emot Rev. 2017;9: 191–199. doi: 10.1177/1754073916684558 28943891

34. Sul S, Tobler PN, Hein G, Leiberg S, Jung D, Fehr E, et al. Spatial gradient in value representation along the medial prefrontal cortex reflects individual differences in prosociality. Proc Natl Acad Sci. 2015;112: 7851–7856. doi: 10.1073/pnas.1423895112 26056280

35. Kriegeskorte N, Goebel R, Bandettini P. Information-based functional brain mapping. Proc Natl Acad Sci U S A. 2006;103: 3863–3868. doi: 10.1073/pnas.0600244103 16537458

36. Kleiner M, Brainard D, Pelli D, Ingling A, Murray R, Broussard C. What’s new in Psychtoolbox-3. Perception. 2007;36: 1.

37. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: an approach to cerebral imaging. 1988;

38. Jimura K, Poldrack RA. Analyses of regional-average activation and multivoxel pattern information tell complementary stories. Neuropsychologia. 2012;50: 544–552. 22100534

39. Pereira F, Botvinick M. Information mapping with pattern classifiers: a comparative study. Neuroimage. 2011;56: 476–496. 20488249

40. Pereira F, Mitchell T, Botvinick M. Machine learning classifiers and fMRI: a tutorial overview. Neuroimage. 2009;45: S199–S209. 19070668

41. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ. Psychophysiological and modulatory interactions in neuroimaging. Neuroimage. 1997;6: 218–229. doi: 10.1006/nimg.1997.0291 9344826

42. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC. Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster-Size Threshold [Internet]. Magnetic Resonance in Medicine. 1995. pp. 636–647. doi: 10.1002/mrm.1910330508 7596267

43. Northoff G, Bermpohl F. Cortical midline structures and the self. Trends Cogn Sci. 2004;8: 102–107. doi: 10.1016/j.tics.2004.01.004 15301749

44. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain’s default network. Ann N Y Acad Sci. 2008;1124: 1–38. doi: 10.1196/annals.1440.011 18400922

45. Sul S, Tobler PN, Hein G, Leiberg S, Jung D, Fehr E, et al. Spatial gradient in value representation along the medial prefrontal cortex reflects individual differences in prosociality. Proc Natl Acad Sci U S A. 2015;112: 7851–7856. doi: 10.1073/pnas.1423895112 26056280

46. McNamee D, Rangel A, O’doherty JP. Category-dependent and category-independent goal-value codes in human ventromedial prefrontal cortex. Nat Neurosci. 2013;16: 479. doi: 10.1038/nn.3337 23416449

47. O’Reilly JX, Woolrich MW, Behrens TEJ, Smith SM, Johansen-Berg H. Tools of the trade: psychophysiological interactions and functional connectivity. Soc Cogn Affect Neurosci. 2012;7: 604–609. doi: 10.1093/scan/nss055 22569188

48. Dambrun M, Ricard M. Self-centeredness and selflessness: A theory of self-based psychological functioning and its consequences for happiness. Rev Gen Psychol. 2011;15: 138–157. doi: 10.1037/a0023059

49. Shi L, Sun J, Wu X, Wei D, Chen Q, Yang W, et al. Brain networks of happiness: dynamic functional connectivity among the default, cognitive and salience networks relates to subjective well-being. Soc Cogn Affect Neurosci. 2018;13: 851–862. doi: 10.1093/scan/nsy059 30016499

50. Schjoedt U, Stødkilde-Jørgensen H, Geertz AW, Roepstorff A. Highly religious participants recruit areas of social cognition in personal prayer. Soc Cogn Affect Neurosci. 2009;4: 199–207. doi: 10.1093/scan/nsn050 19246473

51. FeldmanHall O, Dalgleish T, Evans D, Mobbs D. Empathic concern drives costly altruism. Neuroimage. 2015;105: 347–356. doi: 10.1016/j.neuroimage.2014.10.043 25462694

52. Zaki J, Ochsner KN. The neuroscience of empathy: progress, pitfalls and promise. Nat Neurosci. 2012;15: 675. doi: 10.1038/nn.3085 22504346

53. Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006;129: 564–583. doi: 10.1093/brain/awl004 16399806

54. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci. 2001;98: 676–682. doi: 10.1073/pnas.98.2.676 11209064

55. Rømer Thomsen K, Whybrow PC, Kringelbach ML. Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain. Front Behav Neurosci. 2015;9: 49. doi: 10.3389/fnbeh.2015.00049 25814941

56. Saxe R, Wexler A. Making sense of another mind: the role of the right temporo-parietal junction. Neuropsychologia. 2005;43: 1391–1399. doi: 10.1016/j.neuropsychologia.2005.02.013 15936784

57. O’Doherty J, Kringelbach ML, Rolls ET, Hornak J, Andrews C. Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci. 2001;4: 95. doi: 10.1038/82959 11135651

58. Margulies DS, Ghosh SS, Goulas A, Falkiewicz M, Huntenburg JM, Langs G, et al. Situating the default-mode network along a principal gradient of macroscale cortical organization. Proc Natl Acad Sci U S A. 2016;113: 12574–12579. doi: 10.1073/pnas.1608282113 27791099

59. Schultz PW. The structure of environmental concern: Concern for self, other people, and the biosphere. J Environ Psychol. 2001;21: 327–339.

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