Lipid profile changings after switching from rilpivirine/tenofovir disoproxil fumarate/emtricitabine to rilpivirine/tenofovir alafenamide/emtricitabine: Different effects in patients with or without baseline hypercholesterolemia


Autoři: Lucia Taramasso aff001;  Antonio Di Biagio aff003;  Niccolò Riccardi aff002;  Federica Briano aff002;  Elisa Di Filippo aff005;  Laura Comi aff005;  Sara Mora aff006;  Mauro Giacomini aff006;  Andrea Gori aff007;  Franco Maggiolo aff005
Působiště autorů: Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy aff001;  Department of Health Sciences (DISSAL), University of Genoa, Genova, Italy aff002;  Infectious Diseases Clinic, Policlinico San Martino Hospital, Genoa, Italy aff003;  Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy aff004;  Infectious Disease Unit, ASST Papa Giovanni XXIII, Bergamo, Italy aff005;  Department of Informatics Bioengineering, Robotics, and Systems Engineering (DIBRIS), University of Genova, Genoa, Italy aff006;  Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy aff007
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223181

Souhrn

Tenofovir alafenamide (TAF) has similar efficacy compared to tenofovir disoproxil fumarate (TDF), but a less favorable effect on lipids. Aim of this retrospective multicentre study was to evaluate the impact on lipids of switching from rilpivirine (RPV)/ emtricitabine (FTC)/TDF to RPV/FTC/TAF in a cohort of HIV-1 infected patients. Total cholesterol (TC), high density lipoproteins (HDL) and low density lipoproteins (LDL) were compared at the moment of the switch and at the first following evaluation, by using paired t-test. Overall, 573 patients were considered, 99% with HIV-RNA <50 copies/ml, with mean age of 49.7 (±0.4) years and median 13.4 (6.9–22.5) years of HIV infection. In the study population with available data (431/573, 75%), mean TC changed from 173 ±1.7 to 188 ±1.8 mg/dl; mean HDL from 46 ±0.7 to 51± 0.7 mg/dl; mean LDL from 111 ±1.5 to 120 ±1.8 mg/dl (p<0.0001 for all). Neither LDL/HDL nor TC/HDL ratio changed significantly, with LDL/HDL from 2.6 ±0.5 to 2.5 ±0.5 (p = 0.12) and TC/HDL from 4.0 ±0.6 to 3.9 ±0.6 (p = 0.11). In patients with baseline diagnosis of hypercholesterolemia (TC>200 mg/dl, N = 87), there was no significant change in TC (224 ±2.2 to 228 ±3.4 mg/dl, p = 0.286) or LDL (150±2.5 to 151±3.2 mg/dl, p = 0.751), while HDL increased from 51 ±1.6 to 55 ±1.7 mg/dl (p<0.0001) and both LDL/HDL and TC/HDL ratio decreased significantly, from 3.2±0.1 to 3.0 ±0.1 (p = 0.025) and from 4.7±0.1 to 4.4 ±0.1 (p = 0.004). In this real life study, a slight increase in lipids was found after switching from RPV/FTC/TDF to RPV/FTC/TAF, but these results were not confirmed in people with hypercholesterolemia, in which lipids did not change and LDL/HDL and TC/HDL ratio decreased.

Klíčová slova:

Creatinine – HIV – HIV infections – Cholesterol – Lipids – Lipoproteins – Medical risk factors – Hypercholesterolemia


Zdroje

1. Department of Health and Human Services (DHHS) 2018. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Available at: https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed 25 March 2019.

2. Ray AS, Fordyce MW, Hitchcock MJ. Tenofovir alafenamide: anovel prodrug of tenofovir for the treatment of human immunodeficiency virus. Antivir Res. 2015; 125: 63–70. doi: 10.1016/j.antiviral.2015.11.009 26640223

3. Di Biagio A, Riccardi N, Rusconi S, Guaraldi G, Borderi M, De Luca A, et al. A Comprehensive Development Agenda on Tenofovir Alafenamide in Clinical Practice. AIDS Rev. 2018;20:75–82. doi: 10.24875/AIDSRev.M18000017 29938701

4. Di Giambenedetto S, Fabbiani M, Quiros Roldan E, Latini A, D'Ettorre G, Antinori A, et al. Treatment simplification to atazanavir/ritonavir + lamivudine versus maintenance of atazanavir/ritonavir + two NRTIs in virologically suppressed HIV-1-infected patients: 48 week results from a randomized trial (ATLAS-M). J Antimicrob Chemother. 2017;72:1163–1171. doi: 10.1093/jac/dkw557 28093483

5. Di Biagio A, Riccardi N, Taramasso L, Capetti A, Cenderello G, Signori A, et al. Switch from unboosted protease inhibitor to a single-tablet regimen containing rilpivirine improves cholesterol and triglycerides. Int J Antimicrob Agents. 2016;48:551–554. doi: 10.1016/j.ijantimicag.2016.07.009 27566908

6. Taramasso L, Tatarelli P, Ricci E, Madeddu G, Menzaghi B, Squillace N, et al. Improvement of lipid profile after switching from efavirenz or ritonavir-boosted protease inhibitors to rilpivirine or once-daily integrase inhibitors: results from a large observational cohort study (SCOLTA). BMC Infect Dis. 2018;18(1):357. doi: 10.1186/s12879-018-3268-5 30064371

7. Taramasso L, Ricci E, Menzaghi B, Orofino G, Passerini S, Madeddu G, et al. Weight Gain: A Possible Side Effect of All Antiretrovirals. Open Forum Infect Dis. 2017;4(4):ofx239. doi: 10.1093/ofid/ofx239 29255735

8. Häggblom A, Lindbäck S, Gisslén M, Flamholc L, Hejdeman B, Palmborg A, et al. HIV drug therapy duration; a Swedish real world nationwide cohort study on InfCareHIV 2009–2014. PLoS One. 2017;12(2):e0171227. doi: 10.1371/journal.pone.0171227 28207816

9. Lewis JM, Smith C, Torkington A, Davies C, Ahmad S, Tomkins A, et al. Real-world persistence with antiretroviral therapy for HIV in the United Kingdom: A multicentre retrospective cohort study. J Infect. 2017;74:401–407. doi: 10.1016/j.jinf.2017.01.012 28143756

10. Taramasso L, Di Biagio A, Maggiolo F, Tavelli A, Lo Caputo S, Bonora S, et al. First-line antiretroviral therapy with efavirenz plus tenofovir disiproxil fumarate/emtricitabine or rilpivirine plus tenofovir disiproxil fumarate/emtricitabine: a durability comparison. HIV Med. doi: 10.1111/hiv.12628 [Epub ahead of print]. 29846042

11. Hagins D, Orkin C, Daar ES, Mills A, Brinson C, DeJesus E, et al. Switching to coformulated rilpivirine (RPV), emtricitabine (FTC) and tenofovir alafenamide from either RPV, FTC and tenofovir disoproxil fumarate (TDF) or efavirenz, FTC and TDF: 96-week results from two randomized clinical trials. HIV Med. 2018;19:724–733. doi: 10.1111/hiv.12664 30101539

12. Cid-Silva P, Fernández-Bargiela N, Margusino-Framiñán L, Balboa-Barreiro V, Mena-De-Cea Á, López-Calvo S, et al. Treatment with tenofovir alafenamide fumarate worsens the lipid profile of HIV-infected patients versus treatment with tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine. Basic Clin Pharmacol Toxicol. 2019;124:479–490. doi: 10.1111/bcpt.13161 30388308

13. Giannini B, Riccardi N, Cenderello G, Di Biagio A, Dentone C, Giacomini M. From Liguria HIV Web to Liguria Infectious Diseases Network: How a Digital Platform Improved Doctors' Work and Patients' Care. AIDS Res Hum Retroviruses. 2018;34:239–240. doi: 10.1089/aid.2017.0064 29466022

14. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem.1972;18:499–502. 4337382

15. Hagins D, Orkin C, Daar ES, Mills A, Brinson C, DeJesus E, et al. Switching to coformulated rilpivirine (RPV), emtricitabine (FTC) and tenofovir alafenamide from either RPV, FTC and tenofovir disoproxil fumarate (TDF) or efavirenz, FTC and TDF: 96-week results from two randomized clinical trials. HIV Med. 2018;19:724–733. doi: 10.1111/hiv.12664 30101539

16. Lemieux I, Lamarche B, Couillard C, Pascot A, Cantin B, Bergeron J, et al. Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. Arch Intern Med. 2001;161:2685–92. doi: 10.1001/archinte.161.22.2685 11732933

17. Mutoh Y, Nishijima T, Inaba Y, Tanaka N, Kikuchi Y, Gatanaga H, et al. Incomplete Recovery of CD4 Cell Count, CD4 Percentage, and CD4/CD8 Ratio in Patients With Human Immunodeficiency Virus Infection and Suppressed Viremia During Long-term Antiretroviral Therapy. Clin Infect Dis. 2018;67:927–933. doi: 10.1093/cid/ciy176 29509894

18. Maggi P, Santoro CR, Nofri M, Ricci E, De Gennaro N, Bellacosa C, et al. Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study. BMC Infect Dis. 2019;19:555. doi: 10.1186/s12879-019-4184-z 31238916


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PLOS One


2019 Číslo 10

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