Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance


Autoři: Jacqueline M. Norris aff001;  Annie Zhuo aff003;  Merran Govendir aff001;  Samantha J. Rowbotham aff004;  Maurizio Labbate aff005;  Chris Degeling aff006;  Gwendolyn L. Gilbert aff002;  Dale Dominey-Howes aff002;  Michael P. Ward aff001
Působiště autorů: Sydney School of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia aff001;  Westmead Institute for Medical Research, Sydney, New South Wales, Australia aff002;  School of Geosciences, The University of Sydney, Sydney, New South Wales, Australia aff003;  Menzies Centre for Health Policy, Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia aff004;  School of Life Sciences, University of Technology Sydney, Sydney, New South Wales, Australia aff005;  Australian Centre for Health Engagement, Evidence & Values, School of Health and Society - Faculty of Social Sciences, University of Wollongong, Wollongong, New South Wales, Australia aff006;  Wollongong Antimicrobial Resistance Research Alliance (WARRA), University of Wollongong, Wollongong, New South Wales, Australia aff007;  Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, New South Wales, Australia aff008
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223534

Souhrn

Antimicrobial resistance (AMR) is a global crisis with impacts on the future health and welfare of humans and animals. Determining key factors that influence veterinarians’ antimicrobial prescribing behaviours can bridge the gap between prescribing guidelines and clinical usage. Veterinarians practicing in Australia were surveyed on their frequency in prescribing different antibiotics; factors influencing their antibiotic prescribing behaviours; and their perceptions of current drivers of AMR. Antibiotics were prescribed in a third of consultations with key differences in the frequency of use of specific antibiotics by small companion animal (SCA), equine and livestock veterinarians, which broadly aligned with antibiotic registration restrictions in Australia. SCA veterinarians reported prescribing broad-spectrum antibiotics of higher importance to human health more frequently than livestock veterinarians. Factors that were reported as ‘strong’ or ‘moderate’ barriers to appropriate antibiotic prescribing were the 1) cost of culture and susceptibility testing and 2) lack of access to rapid and affordable diagnostic tests. Fear of losing clients, colleague pressure, and lack of their own understanding about antibiotics were considered to be ‘no’ or ‘somewhat’ of a barrier to appropriate prescribing by respondents. SCA veterinarians placed greater importance on the contribution of antibiotic use in livestock to AMR, than antibiotic use in companion animals. Despite reporting use of fewer, mostly narrow spectrum antibiotics of lower importance to human and animal health, livestock veterinarians were generally more aware of their potential contribution to AMR. This study provides insights into the similarities and differences in SCA, equine and livestock veterinarians practicing in Australia and informs sector-specific strategies to improve antimicrobial stewardship.

Klíčová slova:

Antibiotic resistance – Antibiotics – Antimicrobial resistance – Antimicrobials – Australia – Equines – Livestock care – Veterinarians


Zdroje

1. Ferri M, Ranucci E, Romagnoli P, Giaccone V (2017) Antimicrobial resistance: A global emerging threat to public health systems. Critical Reviews in Food Science Nutrition 57: 2857–2876. doi: 10.1080/10408398.2015.1077192 26464037

2. McCullough AR, Rathbone J, Parekh S, Hoffmann TC, Del Mar CB (2015) Not in my backyard: a systematic review of clinicians' knowledge and beliefs about antibiotic resistance. Journal of Antimicrobial Chemotherapy 70: 2465–2473. doi: 10.1093/jac/dkv164 26093375

3. Zhuo A, Labbate M, Norris JM, Gilbert G, Ward M, et al. (2018) Comparing prescriber groups' knowledge, perceptions, and behaviours highlights opportunities and challenges to taking a One Health approach to antimicrobial resistance. BMJ Open 8: e020439.

4. Swann MM, Baxter KL, Field HI (1969) Report of the Joint Committee on the use of Antibiotics in Animal Husbandry and Veterinary Medicine. HMSO London.

5. NH&MRC (2014) Therapeutic guidelines antibiotic Version 15.

6. AIDAP (2016) Practical Infection Control Guidelines: Australasian infectious diseases advisory panel. Australia.

7. Hardefeldt LY, Browning GF, Crabb H, Bailey KE (2017) Australian Veterinary Prescribing Guidelines. https://vetantibiotics.fvas.unimelb.edu.au/: The University of Melbourne.

8. Weese JS, Giguere S, Guardabassi L, Morley PS, Papich M, et al. (2015) ACVIM Consensus Statement on Therapeutic Antimicrobial Use in Animals and Antimicrobial Resistance. Journal of Veterinary Internal Medicine 29: 487–498. doi: 10.1111/jvim.12562 25783842

9. Weese JS, Blondeau J, Boothe D, Guardabassi LG, Gumley N, et al. (2019) International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. The Veterinary Journal 247: 8–25. doi: 10.1016/j.tvjl.2019.02.008 30971357

10. APVMA (2014) Quantity of antimicrobial products sold for veterinary use in Australia: July 2005 to June 2010. Australian Pesticides and Veterinary Medicines Authority node/11816.

11. Hardefeldt LY, Browning GF, Thursky K, Gilkerson JR, Billman-Jacobe H, et al. (2017) Antimicrobials used for surgical prophylaxis by companion animal veterinarians in Australia. Veterinary Microbiology 203: 301–307. doi: 10.1016/j.vetmic.2017.03.027 28619161

12. Hardefeldt LY, Holloway S, Trott DJ, Shipstone M, Barrs VR, et al. (2017) Antimicrobial Prescribing in Dogs and Cats in Australia: Results of the Australasian Infectious Disease Advisory Panel Survey. Journal of Veterinary Internal Medicine 31: 1100–1107. doi: 10.1111/jvim.14733 28514013

13. Barzelai ID, Whittem T (2017) Survey of systemic antimicrobial prescribing for dogs by Victorian veterinarians. Australian Veterinary Journal 95: 375–385. doi: 10.1111/avj.12637 28948625

14. Hardefeldt LY, Browning GF, Thursky KA, Gilkerson JR, Billman-Jacobe H, et al. (2017) Cross-sectional study of antimicrobials used for surgical prophylaxis by bovine veterinary practitioners in Australia. Veterinary Record 181: 6.

15. Hardefeldt LY, Browning GF, Thursky K, Gilkerson JR, Billman-Jacobe H, et al. (2018) Antimicrobials used for surgical prophylaxis by equine veterinary practitioners in Australia. Equine Veterinary Journal 50: 65–72. doi: 10.1111/evj.12709 28608525

16. Hardefeldt LY, Gilkerson JR, Billman-Jacobe H, Stevenson MA, Thursky K, et al. (2018) Barriers to and enablers of implementing antimicrobial stewardship programs in veterinary practices. Journal of Veterinary Internal Medicine 32: 1092–1099. doi: 10.1111/jvim.15083 29573053

17. Mateus AL, Brodbelt DC, Barber N, Stark KD (2014) Qualitative study of factors associated with antimicrobial usage in seven small animal veterinary practices in the UK. Preventative Veterinary Medicine 117: 68–78.

18. Fowler H, Davis MA, Perkins A, Trufan S, Joy C, et al. (2016) A survey of veterinary antimicrobial prescribing practices, Washington State 2015. Veterinary Record.

19. Gibbons JF, Boland F, Buckley JF, Butler F, Egan J, et al. (2013) Influences on antimicrobial prescribing behaviour of veterinary practitioners in cattle practice in Ireland. Veterinary Record 172: 14. doi: 10.1136/vr.100782 23293148

20. McDougall S, Compton CWR, Botha N (2017) Factors influencing antimicrobial prescribing by veterinarians and usage by dairy farmers in New Zealand. New Zealand Veterinary Journal 65: 84–92. doi: 10.1080/00480169.2016.1246214 27748166

21. Van Cleven A, Sarrazin S, de Rooster H, Paepe D, Van der Meeren S, et al. (2018) Antimicrobial prescribing behaviour in dogs and cats by Belgian veterinarians. Veterinary Record 182: 324. doi: 10.1136/vr.104316 29196488

22. Hopman NEM, Hulscher M, Graveland H, Speksnijder DC, Wagenaar JA, et al. (2018) Factors influencing antimicrobial prescribing by Dutch companion animal veterinarians: A qualitative study. Preventive Veterinary Medicine 158: 106–113. doi: 10.1016/j.prevetmed.2018.07.013 30220383

23. De Briyne N, Atkinson J, Pokludova L, Borriello SP, Price S (2013) Factors influencing antibiotic prescribing habits and use of sensitivity testing amongst veterinarians in Europe. Veterinary Record 173: 475. doi: 10.1136/vr.101454 24068699

24. Postma M, Speksnijder DC, Jaarsma AD, Verheij TJ, Wagenaar JA, et al. (2016) Opinions of veterinarians on antimicrobial use in farm animals in Flanders and the Netherlands. Veterinary Record 179: 68. doi: 10.1136/vr.103618 27313178

25. Australian Government (2016) Implementation Plan: Australia’s First National Antimicrobial Resistance Strategy 2015–2019. Commonwealth of Australia 2016.

26. ASTAG (2018) Australian Strategic and Technical Advisory Group on Antimicrobial Resistance Importance Ratings and Summary of Antibacterial Uses in Humans and Animal Health in Australia.

27. WHO (2016) Antibiotic resistance. The World Health Organisation.

28. AVA. (2015) Australian Veterinary Association. Australian veterinary workforce modelling report.

29. Beco L, Guaguere E, Mendez CL, Noli C, Nuttall T, et al. (2013) Suggested guidelines for using systemic antimicrobials in bacterial skin infections (2): antimicrobial choice, treatment regimens and compliance. Veterinary Record 172: 156–160. doi: 10.1136/vr.101070 23292948

30. Smith M, King C, Davis M, Dickson A, Park J, et al. (2018) Pet owner and vet interactions: exploring the drivers of AMR. Antimicrobial Resistance and Infection Control 7.

31. Hardefeldt L, Nielsen T, Crabb H, Gilkerson J, Squires R, et al. (2018) Veterinary Students' Knowledge and Perceptions About Antimicrobial Stewardship and Biosecurity-A National Survey. Antibiotics 7: 15.

32. Hardefeldt LY, Gilkerson JR, Billman-Jacobea H, Stevensona MA, Thursky K, et al. (2018) The barriers to, and enablers of, implementing antimicrobial stewardship programs in veterinary practices. Journal of Veterinary Internal Medicine.

33. Hardefeldt LY, Gilkerson JR, Billman-Jacobe H, Stevenson MA, Thursky K, et al. (2018) Antimicrobial labelling in Australia: a threat to antimicrobial stewardship? Australian Veterinary Journal 96: 151–154. doi: 10.1111/avj.12677 29691852

34. Tang KL, Caffrey NP, Nóbrega DB, Cork SC, Ronksley PE, et al. (2017) Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis. The Lancet Planetary Health 1: e316–e327. doi: 10.1016/S2542-5196(17)30141-9 29387833

35. Hockenhull J, Turner AE, Reyher KK, Barrett DC, Jones L, et al. (2017) Antimicrobial use in food-producing animals: a rapid evidence assessment of stakeholder practices and beliefs. Veterinary Record 181: 510-+. doi: 10.1136/vr.104304 28847873

36. George A (2018) Antimicrobial resistance, trade, food safety and security. One Health 5: 6–8. doi: 10.1016/j.onehlt.2017.11.004 29255786

37. AURA (2017) AURA 2017 Second Australian Report of Antimicrobial use and resistance in human health. In: Care ACoSaQiH, editor.

38. Buckland EL, O'Neill D, Summers J, Mateus A, Church D, et al. (2016) Characterisation of antimicrobial usage in cats and dogs attending UK primary care companion animal veterinary practices. Veterinary Record 179: 489-+. doi: 10.1136/vr.103830 27543064

39. Singleton DA, Sanchez-Vizcaino F, Dawson S, Jones PH, Noble PJM, et al. (2017) Patterns of antimicrobial agent prescription in a sentinel population of canine and feline veterinary practices in the United Kingdom. Veterinary Journal 224: 18–24.

40. Hardefeldt LY, Selinger J, Stevenson MA, Gilkerson JR, Crabb H, et al. (2018) Population wide assessment of antimicrobial use in dogs and cats using a novel data source—A cohort study using pet insurance data. Veterinary Microbiology 225: 34–39. doi: 10.1016/j.vetmic.2018.09.010 30322530

41. Mateus A, Brodbelt DC, Barber N, Stark KD (2011) Antimicrobial usage in dogs and cats in first opinion veterinary practices in the UK. Journal of Small Animal Practice 52: 515–521. doi: 10.1111/j.1748-5827.2011.01098.x 21824147

42. Murphy CP, Reid-Smith RJ, Boerlin P, Weese JS, Prescott JF, et al. (2012) Out-patient antimicrobial drug use in dogs and cats for new disease events from community companion animal practices in Ontario. Canadian Veterinary Journal 53: 291–298. 22942447

43. Hardefeldt LY (2018) Implementing antimicrobial stewardship programmes in veterinary practices. Veterinary Record 182: 688–690. doi: 10.1136/vr.k2563 29907721

44. Hughes LA, Pinchbeck G, Callaby R, Dawson S, Clegg P, et al. (2013) Antimicrobial prescribing practice in UK equine veterinary practice. Equine Veterinary Journal 45: 141–147. doi: 10.1111/j.2042-3306.2012.00602.x 22994559

45. Allen J, Herbert G, Muscatello G, Gilkerson J (2015) Antimicrobial susceptibility of Australian virulent Rhodococcus equi isolates collected between 119 and 2014 Equine Veterinary Journal 47: 3.3.

46. Murphy RJT, Ramsay JP, Lee YY, Pang S, O'Dea MA, et al. (2019) Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. International Journal of Antimicrobial Agents In press Available online 31 August 2019.

47. Saputra S, Jordan D, Worthing KA, Norris JM, Wong HS, et al. (2017) Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study. PLOS ONE 12.

48. Shaban RZ, Simon GI, Trott DJ, Turnidge J, Jordan D (2014) Surveillance and reporting of antimicrobial resistance and antibiotic usage in animals and agriculture in Australia. Report to the Department of Agriculture.

49. Van Breda LK, Dhungyel OP, Ward MP (2018) Antibiotic resistant E. coli in southeastern Australian pig herds and implications for surveillance. Zoonoses and Public Health 65: e1–e7. doi: 10.1111/zph.12402 28921905

50. Worthing KA, Abraham S, Pang S, Coombs GW, Saputra S, et al. (2018) Molecular Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Australian Animals and Veterinarians. Microbial Drug Resistance 24: 203–212. doi: 10.1089/mdr.2017.0032 28598251

51. Worthing KA, Abraham S, Coombs GW, Pang S, Saputra S, et al. (2018) Clonal diversity and geographic distribution of methicillin-resistant Staphylococcus pseudintermedius from Australian animals: Discovery of novel sequence types. Veterinary Microbiology 213: 58–65. doi: 10.1016/j.vetmic.2017.11.018 29292005

52. Saputra S, Jordan D, Mitchell T, Wong HS, Abraham RJ, et al. (2017) Antimicrobial resistance in clinical Escherichia coli isolated from companion animals in Australia. Veterinary Microbiology 211: 43–50. doi: 10.1016/j.vetmic.2017.09.014 29102120


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