Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum


Autoři: Felipe Kenji Sudo aff001;  Andrea Silveira de Souza aff001;  Claudia Drummond aff001;  Naima Assuncao aff001;  Alina Teldeschi aff001;  Natalia Oliveira aff001;  Fernanda Rodrigues aff001;  Gustavo Santiago-Bravo aff001;  Victor Calil aff001;  Gabriel Lima aff001;  Pilar Erthal aff001;  Gabriel Bernardes aff001;  Marina Monteiro aff001;  Fernanda Tovar-Moll aff001;  Paulo Mattos aff001
Působiště autorů: D’Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil aff001;  Department of Speech and Hearing Pathology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil aff002;  Morphological Sciences Program, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil aff003;  Post-Graduation Program in Clinical Medicine, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil aff004;  Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil aff005
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223731

Souhrn

Background

Episodic memory impairments have been described as initial clinical findings in the Alzheimer’s Disease (AD) spectrum, which could be associated with the presence of early hippocampal dysfunction. However, correlates between performances in neuropsychological tests and hippocampal volumes in AD were inconclusive in the literature. Divergent methods to assess episodic memory have been depicted as a major source of heterogeneity across studies.

Methods

We examined correlates among performances in three different delayed-recall tasks (Rey-Auditory Verbal-Learning Test–RAVLT, Logical Memory and Visual Reproduction subtests from the Wechsler Memory Scale) and fully-automated volumetric measurements of the hippocampus (estimated using Neuroquant®) of 83 older subjects (47 controls, 27 Mild Cognitive Impairment individuals and 9 participants with Dementia due to AD).

Results

Inter-method correlations of episodic memory performances were at most moderate. Scores in the RAVLT predicted up to 48% of variance in HOC (Hippocampal Occupancy Score) among subjects in the AD spectrum.

Discussion

Tests using different stimuli (verbal or visual) and presenting distinct designs (word list, story or figure learning) may assess divergent aspects in episodic memory, with heterogeneous anatomical correlates.

Conclusions

Different episodic memory tests might not assess the same construct and should not be used interchangeably. Scores in RAVLT may correlate with the presence of neurodegeneration in AD.

Klíčová slova:

Alzheimer's disease – Cognitive impairment – Hippocampus – Learning – Memory – Memory recall – Neuropsychological testing – Vision


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