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Plasma sCD36 as non-circadian marker of chronic circadian disturbance in shift workers


Autoři: Daniella van de Langenberg aff001;  Jelle J. Vlaanderen aff001;  Martijn E. T. Dolle aff002;  Aase Handberg aff003;  Roel C. H. Vermeulen aff001;  Linda W. M. van Kerkhof aff002
Působiště autorů: IRAS, Institute for Risk Assessment, Utrecht University, Utrecht, the Netherlands aff001;  RIVM, National Institute for Public Health and the Environment, Bilthoven, the Netherlands aff002;  Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark aff003;  Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223522

Souhrn

Shift work induces chronic circadian disturbance, which might result in increased health risks, including cardio-metabolic diseases. Previously, we identified sCD36 as a potential non-circadian biomarker of chronic circadian disturbance in mice. The aim of the current study (n = 232 individuals) was to identify whether sCD36 measured in plasma can be used as a non-circadian marker of chronic circadian disturbance in humans, which would allow its use to measure the effects of interventions and monitoring in large-scale studies. We compared levels of plasma sCD36 of day workers with recent (< 2 years) and experienced (> 5 years) night-shift workers within the Klokwerk study. We detected no differences in sCD36 levels between day workers and recent or experienced night-shift workers, measured during a day or afternoon shift. In addition, sCD36 levels measured directly after a night shift were not different from sCD36 levels measured during day or afternoon shifts, indicating no acute effect of night shifts on sCD36 levels in our study. In summary, our study does not show a relation between night-shift work experience (recent or long-term) and plasma levels of sCD36. Since we do not know if and for which time span night-shift work is associated with changes in sCD36 levels, and our study was relatively small and cross-sectional, further evidence for an association between chronic circadian disruption and this candidate biomarker sCD36 should be gathered from large cohort studies.

Klíčová slova:

Biomarkers – Blood – Blood plasma – Circadian rhythms – Cohort studies – Chronobiology – Obesity – Specimen disruption


Zdroje

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