Magnetic resonance imaging presentation of deep infiltrating endometriosis nodules before and after pregnancy: A case series


Autoři: Anne Elodie Millischer aff001;  Louis Marcellin aff002;  Pietro Santulli aff002;  Chloe Maignien aff002;  Mathilde Bourdon aff002;  Bruno Borghese aff002;  François Goffinet aff005;  Charles Chapron aff002
Působiště autorů: Centre de Radiologie IMPC Bachaumont Pole femme-mere-enfant, Paris, France aff001;  Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique–Hôpitaux de Paris (AP-HP), Service de Chirurgie Gynécologie Obstétrique II et Médecine de la Reproduction, Hôpital Universitaire Paris Centre (HUPC), Centre Hospital aff002;  Equipe Stress Oxydant, Prolifération Cellulaire et Inflammation, Département Développement, Reproduction, Cancer, Inserm U1016, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, AP-HP, HUPC, CHU Cochin, Paris, France aff003;  Equipe Génomique, Epigénétique et Physiopathologie de la Reproduction, Département Développement, Reproduction, Cancer, Inserm U1016, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, AP-HP, HUPC, CHU Cochin, Paris, France aff004;  Port Royal Maternity Unit, Cochin Hospital, Assistance Publique des Hôpitaux de Paris, DHU Risks and Pregnancy, Paris Descartes University, Paris, France aff005
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223330

Souhrn

Objective

To compare the magnetic resonance imaging (MRI) features of deep infiltrating endometriosis (DIE) lesions before and after pregnancy.

Design

Retrospective study.

Setting

A single French university tertiary referral hospital.

Patients

Twenty-one women without a prior history of surgery for endometriosis with a radiological diagnosis by MRI with two sets of examinations performed before and after pregnancy.

Interventions

The volumes of the lesions were compared using the same protocol before and after pregnancy based on MRI (1.5 T) examinations by a single experienced radiologist who is a referring practitioner for image-based diagnosis of endometriosis.

Main outcome measure(s)

The DIE lesion volume.

Measurements and main results

Between October 2012 and December 2016, a total of 21 patients (67 lesions) were included and compared before and after pregnancy. The mean time interval between the MRI before pregnancy and delivery was 19.6 ± 8.5 months (median: 17.6, IQR 13.5–25.2 months). The mean time interval between delivery and the MRI after pregnancy was 11.0 ± 6.4 months (median: 8.3, IQR 6–15.2 months). The mean overall DIE lesion volume by MRI was significantly higher before pregnancy compared to after pregnancy (2,552 ± 3,315 mm3 vs. 1,708 ± 3,266 mm3, respectively, p < 0.01). The mean volume by MRI of the largest lesion of each patient was significantly higher before pregnancy compared to after pregnancy (4,728 ± 4,776 mm3 vs. 3165 ± 5299 mm3; p < 0.01).

Conclusion

Our data indicate a favorable impact of pregnancy on DIE lesion volumes as measured by MRI.

Klíčová slova:

Bladder – Hypertensive disorders in pregnancy – Labor and delivery – Lesions – Magnetic resonance imaging – Obstetric procedures – Pregnancy – Surgical and invasive medical procedures


Zdroje

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