Tissue-specific changes in size and shape of the ligaments and tendons of the porcine knee during post-natal growth

Autoři: Stephanie G. Cone aff001;  Hope E. Piercy aff001;  Emily P. Lambeth aff001;  Hongyu Ru aff003;  Jorge A. Piedrahita aff002;  Jeffrey T. Spang aff004;  Lynn A. Fordham aff005;  Matthew B. Fisher aff001
Působiště autorů: Department of Biomedical Engineering, North Carolina State University and the University of North Carolina at Chapel Hill, Raleigh, North Carolina, United States of America aff001;  Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America aff002;  Department of Biostatistics, North Carolina State University, Raleigh, North Carolina, United States of America aff003;  Department of Orthopedics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America aff004;  Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America aff005
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0219637


Prior studies have analyzed growth of musculoskeletal tissues between species or across body segments; however, little research has assessed the differences in similar tissues within a single joint. Here we studied changes in the length and cross-sectional area of four ligaments and tendons, (anterior cruciate ligament, patellar tendon, medial collateral ligament, lateral collateral ligament) in the tibiofemoral joint of female Yorkshire pigs through high-field magnetic resonance imaging throughout growth. Tissue lengths increased by 4- to 5-fold from birth to late adolescence across the tissues while tissue cross-sectional area increased by 10–20-fold. The anterior cruciate ligament and lateral collateral ligament showed allometric growth favoring change in length over change in cross-sectional area while the patellar tendon and medial collateral ligament grow in an isometric manner. Additionally, changes in the length and cross-sectional area of the anterior cruciate ligament did not increase as much as in the other ligaments and tendon of interest. Overall, these findings suggest that musculoskeletal soft tissue morphometry can vary within tissues of similar structure and within a single joint during post-natal growth.

Klíčová slova:

Age groups – Body limbs – Ligaments – Magnetic resonance imaging – Morphometry – Pig models – Skeletal joints – Tendons


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