Cardiorespiratory factors related to the increase in oxygen consumption during exercise in individuals with stroke

Autoři: Kazuaki Oyake aff001;  Yasuto Baba aff002;  Nao Ito aff002;  Yuki Suda aff002;  Jun Murayama aff002;  Ayumi Mochida aff002;  Kunitsugu Kondo aff002;  Yohei Otaka aff002;  Kimito Momose aff001
Působiště autorů: Department of Physical Therapy, School of Health Sciences, Shinshu University, Matsumoto, Nagano, Japan aff001;  Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Narashino, Chiba, Japan aff002;  Department of Rehabilitation Medicine I, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan aff003
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article



Understanding the cardiorespiratory factors related to the increase in oxygen consumption (V˙O2) during exercise is essential for improving cardiorespiratory fitness in individuals with stroke. However, cardiorespiratory factors related to the increase in V˙O2 during exercise in these individuals have not been examined using multivariate analysis. This study aimed to identify cardiorespiratory factors related to the increase in V˙O2 during a graded exercise in terms of respiratory function, cardiac function, and the ability of skeletal muscles to extract oxygen.


Eighteen individuals with stroke (aged 60.1 ± 9.4 years, 67.1 ± 30.8 days poststroke) underwent a graded exercise test for the assessment of cardiorespiratory response to exercise. The increases in V˙O2 from rest to first threshold and that from rest to peak exercise were measured as a dependent variable. The increases in respiratory rate, tidal volume, minute ventilation, heart rate, stroke volume, cardiac output, and arterial-venous oxygen difference from rest to first threshold and those from rest to peak exercise were measured as the independent variables.


From rest to first threshold, the increases in arterial-venous oxygen difference (β = 0.711) and cardiac output (β = 0.572) were significant independent variables for the increase in V˙O2 (adjusted R2 = 0.877 p < 0.001). Similarly, from rest to peak exercise, the increases in arterial-venous oxygen difference (β = 0.665) and cardiac output (β = 0.636) were significant factors related to the increase in V˙O2 (adjusted R2 = 0.923, p < 0.001).


Our results suggest that the ability of skeletal muscle to extract oxygen is a major cardiorespiratory factor related to the increase in V˙O2 during exercise testing in individuals with stroke. For improved cardiorespiratory fitness in individuals with stroke, the amount of functional muscle mass during exercise may need to be increased.

Klíčová slova:

Cardiac output – Exercise – Heart rate – Oxygen – Respiration – Skeletal muscles – stroke – Tidal volume


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