Sialochemical analysis in polytraumatized patients in intensive care units

Autoři: Maria Heloisa Madruga Chaves aff001;  Amanda Rebeca da Silveira Wolf aff001;  Kelly Aline Lima Nascimento aff001;  Danielle Nawcki aff001;  Gabriele Muller Feustel aff001;  Patricia Vida Cassi Bettega aff002;  Sergio Aparecido Ignacio aff002;  João Armando Brancher aff002;  Luana Alves Tannous aff003;  Renata Iani Werneck aff002;  Paulo Henrique Couto Souza aff002;  Marlene Maria Tourais de Barros aff004;  Aline Cristina Batista Rodrigues Johann aff002
Působiště autorů: School of Life Sciences, Department of Nursing, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil aff001;  School of Life Sciences, Department of Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil aff002;  School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil aff003;  Instituto Ciências da Saúde, Universidade Católica Portuguesa-Viseu, Viseu, Portugal aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article


The profiles of polytraumatized patients in intensive care units were characterized. Serum and salivary markers were compared with normality between Classes I and II of APACHE II and between periods of hospitalization; these results were correlated. This was a prospective study on saliva charts and collection (n = 70). Profile: male, 27 years old, blunt traumas and collisions. Serum parameters with normality: decrease in pH, creatinine at admission to Class I, and at 48 and 72 hours in both classes; K+ at 48 h in Class II; Ca+ on admission in both classes and at 72 h in Class I. Increase in urea at 72 h in Class II, glucose at all times and in all classes, and Ca+ at 48 h in both classes. Class II had high Na+ at 48 and 72 h compared to Class I. In Class I, creatinine reduction occurred in 48 h and 72 h compared to admission and an increase of Ca+ at 48 h with admission. In Class II, pH and Na+ increased at 48 h and 72 h compared to admission. K+ decreased from admission to 48 h and increased from 48 h to 72 h. Urea increased from 48 to 72 hours. Creatinine decreased from admission to 48 and 72 hours. Ca+ increased from admission to 48 hours and decreased from 48 to 72 hours. There was an increase in the saliva levels in both classes and times in relation to normality. There was an increase in urea at admission, glucose at 72 h, and Ca+ at 48 h in Class II compared with Class I. Class I urea increased from admission to 48 h and Ca+ decreased from admission to 48 h. Class II urea decreased from 48 h to 72 h. Strong or very strong positive correlation was identified between blood and creatinine saliva at all times and regular and negative Ca+ at 72 h. This study provides evidence that salivary and serum biomarkers can be used together to monitor the evolution of the clinical symptoms of ICU patients.

Klíčová slova:

Blood – Creatinine – Glucose – Intensive care units – Renal system – Saliva – Urea


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