Sialochemical analysis in polytraumatized patients in intensive care units


Autoři: Maria Heloisa Madruga Chaves aff001;  Amanda Rebeca da Silveira Wolf aff001;  Kelly Aline Lima Nascimento aff001;  Danielle Nawcki aff001;  Gabriele Muller Feustel aff001;  Patricia Vida Cassi Bettega aff002;  Sergio Aparecido Ignacio aff002;  João Armando Brancher aff002;  Luana Alves Tannous aff003;  Renata Iani Werneck aff002;  Paulo Henrique Couto Souza aff002;  Marlene Maria Tourais de Barros aff004;  Aline Cristina Batista Rodrigues Johann aff002
Působiště autorů: School of Life Sciences, Department of Nursing, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil aff001;  School of Life Sciences, Department of Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil aff002;  School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil aff003;  Instituto Ciências da Saúde, Universidade Católica Portuguesa-Viseu, Viseu, Portugal aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222974

Souhrn

The profiles of polytraumatized patients in intensive care units were characterized. Serum and salivary markers were compared with normality between Classes I and II of APACHE II and between periods of hospitalization; these results were correlated. This was a prospective study on saliva charts and collection (n = 70). Profile: male, 27 years old, blunt traumas and collisions. Serum parameters with normality: decrease in pH, creatinine at admission to Class I, and at 48 and 72 hours in both classes; K+ at 48 h in Class II; Ca+ on admission in both classes and at 72 h in Class I. Increase in urea at 72 h in Class II, glucose at all times and in all classes, and Ca+ at 48 h in both classes. Class II had high Na+ at 48 and 72 h compared to Class I. In Class I, creatinine reduction occurred in 48 h and 72 h compared to admission and an increase of Ca+ at 48 h with admission. In Class II, pH and Na+ increased at 48 h and 72 h compared to admission. K+ decreased from admission to 48 h and increased from 48 h to 72 h. Urea increased from 48 to 72 hours. Creatinine decreased from admission to 48 and 72 hours. Ca+ increased from admission to 48 hours and decreased from 48 to 72 hours. There was an increase in the saliva levels in both classes and times in relation to normality. There was an increase in urea at admission, glucose at 72 h, and Ca+ at 48 h in Class II compared with Class I. Class I urea increased from admission to 48 h and Ca+ decreased from admission to 48 h. Class II urea decreased from 48 h to 72 h. Strong or very strong positive correlation was identified between blood and creatinine saliva at all times and regular and negative Ca+ at 72 h. This study provides evidence that salivary and serum biomarkers can be used together to monitor the evolution of the clinical symptoms of ICU patients.

Klíčová slova:

Blood – Creatinine – Diabetes mellitus – Glucose – Intensive care units – Renal system – Saliva – Urea


Zdroje

1. World Health Organization, Pan American Health Organization Brazil [World Health Organization, Pan American Health Organization Brazil]. Traumas kill more than the three major endemics: malaria, tuberculosis and AIDS. Brasília (DF): Pan American Health Organization Brazil; 2016 [cited 2018 Nov 15]. Available from: http://www.paho.org/bra…/index.php?option=com_content&view=article&id=2989. Portuguese.

2. World Health Organization. Injuries and violence: the facts [Internet]. Geneva: World Health Organization; c2010 [cited 2007 Mar 26]. 19 p. Available from: https://www.who.int/violence_injury_prevention/key_facts/en/.

3. Bacchieri G, Barros AJD. [Traffic accidents in Brazil from 1998 to 2010: many changes and few effects]. Rev Saude Publica [Internet]. 2011 Oct [cited 2018 Aug 12];45(5):949–63. Available from: http://www.scielo.br/scielo.php?pid=S0034-89102011000500017&script=sci_abstract&tlng=pt. Portuguese. doi: 10.1590/s0034-89102011005000069 21953026

4. Sociedade Brasileira de Atendimento Integral ao Traumatizado. Basta! Arguably, it can not be left alone in the speech. Trauma BoleTeam [Internet]. 2014 Jun 24 [cited 2018 Jun 15];Prevenção:[about 1 p.]. Available from: http://www.sbait.org.br/trauma.php. Portuguese.

5. American College of Surgeons, Advanced Trauma Life Support. About Advanced Trauma Life Support [Internet]. Chicago: American College of Surgeons; c2018 [cited 2018 Nov 5]. Available from: https://www.facs.org/quality-programs/trauma/atls/about.

6. Wilson JL, Herbella FAM, Takassi GF, Moreno DG, Tineli AC. Fatal trauma injuries in a brazilian big metropolis: a study of autopsies. Rev Col Bras Cir [Internet]. 2011 [cited 2018 Apr 18];38(2):122–6. Available from: http://www.scielo.br/scielo.php?pid=S0100-69912011000200010&script=sci_abstract&tlng=es. doi: 10.1590/S0100-69912011000200010 21710051

7. Krokoscz DVC. Effects of staff allocation and nursing workload on outcomes of care in medical-surgical units [8 thesis on the Internet]. São Paulo (SP): Universidade de São Paulo; 2007 [cited 2017 Nov 3]. 101 p. Available from: http://www.teses.usp.br/teses/disponiveis/7/7139/tde-20062007-102806/pt-br.php. Portuguese.

8. Car MR. Nursing problems of the physical sphere in hospitalized patients: characterization by hospitalization units, semi intensive care and intensive treatment [thesis]. São Paulo (SP): School of Nursing, University of São Paulo; 1986. Portuguese.

9. Tranquitelli AM, Ciampone MHT. [Number of nursing care hours in an intensive care unit]. Rev Esc Enferm USP [Internet]. 2007 Sep [cited 2018 Jan 18];41(3):371–7. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342007000300005. Portuguese. doi: 10.1590/s0080-62342007000300005 17977372

10. Couto RC, Botoni FA, Serufo JC, Nogueira JM, Correa MM, Reis MAS, et al. Ratton-Emergências Médicas e Terapia Intensiva. Rio de Janeiro: Guanabara Koogan; 2005. Portuguese.

11. Cardozo Júnior LCM, Silva RR. Sepsis in intensive care unit patients with traumatic brain injury: factors associated with higher mortality. Rev Bras Ter Intensiva [Internet]. 2014 [cited 2017 Apr 20];26(2):148–54. Available from: http://www.scielo.br/scielo.php?pid=S0103-507X2014000200148&script=sci_abstract. doi: 10.5935/0103-507X.20140022 25028949

12. Santos AACS, Godoy MF. Critical analysis of the request for complementary exams in pediatrics. Pediatrics. 1999;2(3):215–21. Portuguese.

13. Evia JRB. Inappropriate use of the clinical laboratory. Rev Mex Patol Clin [Internet]. 2003 Oct-Dec [cited 2017 Jan 29];50(4):209–23. Available from: https://www.medigraphic.com/pdfs/patol/pt-2003/pt034e.pdf. Spanish.

14. Mehari SM, Havill JH, Montgomery C. A written guideline implementation can lad to reductions in the laboratory testing in an intensive care unit. Anaesth Intensive Care [Internet]. 1997 Feb [cited 2018 Apr 11];25(1):33–7. Available from: https://aaic.net.au/document/?D=1996101. doi: 10.1177/0310057X9702500106 9075511

15. Zimmerman JE, Seneff MG, Sun X, Wagner DP, Knaus WA. Evaluating laboratory usage in the intensive care unit: patient and institutional characteristics that influence frequency of blood sampling. Crit Care Med [Internet]. 1997 May [cited 2018 Jun 22];25(5):737–48. Available from: https://insights.ovid.com/pubmed?pmid=9187590. doi: 10.1097/00003246-199705000-00006 9187590

16. Flabouris A, Bishop G, Williams L, Cunningham M. Routine blood test ordering for patients in the intensive care. Anaesth Intensive Care [Internet]. 2000 Oct [cited 2018 Oct 22];28(5):562–65. Available from: https://aaic.net.au/document/?D=2000031. doi: 10.1177/0310057X0002800515 11094676

17. Kaufman E, Lamster IB. The diagnostic applications of saliva—a review. Crit Rev Oral Biol Med [Internet]. 2002 [cited 2018 Dec 11];13(2):197–212. Available from: https://journals.sagepub.com/doi/full/10.1177/154411130201300209. doi: 10.1177/154411130201300209 12097361

18. Dawes C. Considerations in the development of diagnostic tests on saliva. Ann N Y Acad Sci [Internet]. 1993 Sep [cited 1993 Dec 12];20(694):265–9. Available from: https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1993.tb18359.x?sid=nlm%3Apubmed doi: 10.1111/j.1749-6632.1993.tb18359.x

19. Moura SAB. Clinical, sialometric and sialochemical analyzes in individuals with oral burning syndrome [dissertation]. João Pessoa (PB): Universidade Federal da Paraíba, Universidade Federal da Bahia; 2004. Portuguese.

20. Wang B, Du J, Zhu Z, Ma Z, Wang S, Shan Z. Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and Monitoring Type 2 Diabetes 18 Mellitus Patients. Biomed Res Int [Internet]. 2017 Jan 5 [cited 2018 Jan 22];2017(1):1–5. Available from: https://www.hindawi.com/journals/bmri/2017/2569707/. doi: 10.1155/2017/2569707

21. Kovalč´ıkova A, Jansákova K, Gyurászová M, Podracká L, Sebeková K, Celec P, et al. Salivary creatinine and urea higher in an experimental model of acute but not chronic renal disease. PLoS One [Internet]. 2018 Jul 6 [cited 2018 Jan 12];13(7):1–11. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034877/pdf/pone.0200391.pdf. doi: 10.1371/journal.pone.0200391 29979784

22. Tzira D, Prezerakou A, Papadatos I, Vintila A, Bartzeliotou A, Apostolakou F, et al. Salivary Biomanrkers May Mensure Stress Responses in Critically ill Children. SAGE Open Med [Internet]. 2018 Sep 25 [cited 2018 Jul 16];6:1–10. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156207/. doi: 10.1177/2050312118802452 30263122

23. Bartanusz V, Corneille MG, Sordo S, Gildea M, Michalek JE, Prakash VN, et al. Diurnal salivar cortisol measurement in the neurosurgical-surgical 30 intensive care unit in critically ill acute trauma patients. J Clin Neurosci [Internet]. 2014 Dec [cited 2017 Oct 22];21(12):2150–4. Available from: doi: 10.1016/j.jocn.2014.04.018 25065844

24. Rodrigues PV, Franco MM, Marques CPC, Carvalho RCC, Leite SAM, Pereira ALA, et al. Salivary levels of calcium, phosphorus, potassium, albumin and correlation with serum biomarkers in hemodialysis patients. Arch Oral Biol [Internet]. 2016 Feb [cited 2018 Apr 24];62:58–63. Available from: https://www.sciencedirect.com/science/article/pii/S0003996915300881?via%3Dihub. doi: 10.1016/j.archoralbio.2015.11.016 26655748

25. Knaus WA, Zimmermann JE, Wagner DP, Draper EA, Lawrence DE. APACHE-acute physiology and chronic health evaluation: a physiologically based classification system. Crit Care Med. 1981 Aug;9(8):591–7. doi: 10.1097/00003246-198108000-00008 7261642

26. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818–17. 3928249

27. Knaus WA, Wagner DP, Draper EA, Zimmerman JE, Bergner M, Bastos PG, et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest [Internet]. 1991 Dec [cited 2018 May 15];100(6):1619–36. Available from: doi: 10.1378/chest.100.6.1619 1959406

28. Resolution RDC No. 7 of February 24, 2010 (BR). It provides for the minimum requirements for the operation of Intensive Care Units and provides other measures. 2010 Feb 25 [cited 2018 Jan 18]. Available from: http://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2010/res0007_24_02_2010.html. Portuguese.

29. Portaria nº 3.432 of 12, of August of 1998 (BR). Establishes classification criteria for Intensive Care Units (ICUs). 1998 Aug 13 [cited 2018 Jun 1]. Available from: http://bvsms.saude.gov.br/bvs/saudelegis/gm/1998/prt3432_12_08_1998.html. Portuguese.

30. Ordoñez CA, Badiel M, Sánchez AI, Granados M, García AF, Ospina G, et al. Improving mortality predictions in trauma patients undergoing damage control strategies. Am Surg [Internet]. 2011 Jun [cited 2018 Apr 9];77(6):778–82. Available from: https://www.ingentaconnect.com/content/sesc/tas/2011/00000077/00000006/art00037%3bjsessionid=15ow9f51g9rr0.x-ic-live-02. 21679650

31. Zimmerman JE, Kramer AA, McNair DS, Malila FM. Acute Physiology and Chronic Health Evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patients. Crit Care Med [Internet]. 2006 May [cited 2018 Nov 5];34(5):1297–310. Available from: https://insights.ovid.com/pubmed?pmid=16540951. doi: 10.1097/01.CCM.0000215112.84523.F0 16540951

32. Canova JCM, Bueno MFR, Oliver CCD, Souza LA, Belati LA, Cesarino CB, et al. Cranioencephalic trauma of patients who have been victims of motorcycle accidents. Arq Ciênc Saúde [Internet]. 2010 Jan-Mar [cited 2017 Oct 1];17(1):9–14. Available from: http://repositorio-racs.famerp.br/racs_ol/vol-17-1/IDL_jan-mar_2010.pdf. Portuguese.

33. Chalya PL, Gilyoma JM, Dass RM, Mchembe MD, Matasha M, Mabula JB, et al. Trauma admissions to the intensive care unit at a reference hospital in Northwestern Tanzania. Scand J Trauma Resusc Emerg Med [Internet]. 2011 Oct [cited 2018 Feb 20];19:61. Available from: doi: 10.1186/1757-7241-19-61 22024353

34. Gross T, Attenberger C, Huegli RW, Amsler F. Factors associated with reduced longer-term capacity to work in patients after polytrauma: a Swiss trauma center experience. J Am Coll Surg [Internet]. 2010 Jul [cited 2018 Feb 3];211(1):81–91. Available from: doi: 10.1016/j.jamcollsurg.2010.02.042 20610253

35. Tolotti VC, Silva LAA. Characterization of the victims of trauma treated in a hospital emergency in the north of the state of Rio Grande do Sul. Rev Contexto & Saúde [Internet]. 2004 Jul-Dec [cited 2018 Dec 2];4(7):191–8. Available from: https://www.revistas.unijui.edu.br/index.php/contextoesaude/article/view/1338. doi: 10.21527/2176-71142004.07.191–198

36. Costa JI, Amaral JLG, Munechika M, Juliano Y, Bezerra Filho JG. Severity and prognosis in intensive care: prospective application of the APACHE II index. Sao Paulo Med J [Internet]. 1999 Sep [cited 2018 Jan 28];117(5):205–14. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801999000500005. doi: 10.1590/s1516-31801999000500005 10592133

37. Bales ME, Johnson SB, Keeling JW, Carley KM, Kunkel F, Merrill JA. Evolution of coauthorship in public health services and systems research. Am J Prev Med [Internet]. 2011 Jul [cited 2017 Sep 20];41(1):112–7. Available from: doi: 10.1016/j.amepre.2011.03.018 21665073

38. Santos AMR, Moura MEB, Nunes BMVT, Leal CFS, Teles JBM. [Profile of motorcycle accident victims treated at a public hospital emergency department]. Cad Saude Publica [Internet]. 2008 Aug [cited 2018 Jul 10];24(8):1927–38. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008000800021. doi: 10.1590/s0102-311x2008000800021 Portuguese. 18709233

39. Guyton AC, Hall JE. Treaty of Medical Physiology. Rio de Janeiro: Elsevier; 2006. Portuguese.

40. Kellum JA. Disorders of acid-base balance. Crit Care Med [Internet]. 2007 Nov 1 [cited 2018 Dec 1];35(11):2630–6. Available from: https://europepmc.org/abstract/med/17893626. doi: 10.1097/01.CCM.0000286399.21008.64 17893626

41. Évora PRB, Garcia LV. [Acid-base balance]. Medicina [Internet]. 2008 [cited 2017 Oct 20];41(3):301–11. Available from: http://www.revistas.usp.br/rmrp/article/view/275/276. Portuguese.

42. Association of Brazilian Intensive Medicine, Mechanical Ventilation Committee; Brazilian Society of Pulmonology and Tisiology, SBPT Intensive Care Committee. Brazilian Guidelines on Mechanical Ventilation-2013 [Internet]. [São Paulo]: Association of Brazilian Intensive Medicine; 2013 [cited 2018 Oct 27]. 136 p. Available from: https://edisciplinas.usp.br/pluginfile.php/237544/mod_resource/content/1/Consenso%20VM%202013.pdf.

43. Riella MC. Principles of nephrology and hydroelectrolytic disorders. 4. ed. Rio de Janeiro: Guanabara Koogan; 2003. Portuguese.

44. Palevsky PM, Metnitz PG, Piccinni P, Vinsonneau C. Selection of endpoints 13 for clinical trials of acute renal failure in critically ill patients. Curr Opin Crit Care [Internet]. 2002 Dec [cited 2018 Jul 2];8(6):515–8. Available from: https://insights.ovid.com/pubmed?pmid=12454535. 12454535

45. Greabu MI, Battino M, Mohora M, Totan A, Didilescu A, Spinu T, et al. Saliva-a diagnostic window to the body, both in health and in disease. J Med Life [Internet]. 2009 Apr-Jun [cited 2018 Dec 3];2(2):124–32. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018981/. 20108531

46. Lima OPSC. Reading and interpretation of nursing exams. 3. ed. Goiânia: AB; 2008. Portuguese.

47. Garcia TPR, Romero MP, Poletti NAA, Cesarino CB, Ribeiro RCHM. [Main Reasons of Patient’s Hospitalization with Acute Renal Failure in Intensive Care Unit]. Arq Clinc Saúde [Internet]. 2005 Jul-Sep [cited 2018 Jun 11];12(3):146–50. Available from: http://repositorio-racs.famerp.br/racs_ol/vol-12-3/05%20-%20ID108.pdf. Portuguese.

48. Batista PBP, Santos OFP. IRA Prognoses. In: Schor N, Boim MA, Santos OFP. Acute renal failure. 2. ed. São Paulo: Sarvier; 1997. p. 333–51. Portuguese.

49. Gamarra G, Dí Achiardi RR, Ordonez JD, Torres IH. Acute renal failure. Acta Med Colomb. 1981;6(1):17–22.

50. Moura SAB, Medeiros AMC, Costa FRH, Moraes PH, Oliveira Filho SA. [Diagnostic Value of Saliva in Oral and Systemic Diseases: A Literature Review]. Pesqui Bras Odontopediatria Clin Integr [Internet]. 2007 May-Aug [cited 2018 May 2];7(2):187–94. Available from: http://revista.uepb.edu.br/index.php/pboci/article/view/200/147. doi: 10.4034/pboci.v7i2.200 Portuguese.

51. Polita JR, Gomez J, Friedman G, Ribeiro SP. Comparison of APACHE II and 19 three abbreviated APACHE II scores for predicting outcome among emergency trauma patients. Rev Assoc Med Bras [Internet]. 2014 [cited 2017 Dec 1];60(4):381–386. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302014000400381. doi: 10.1590/1806-9282.60.04.018 25211423

52. Bilancio G, Cavallo P, Lombardi C, Guarino E, Cozza V, Giordano F, et al. Salivary levels of phosphorus and urea as indices of their plasma levels in nephropathic patients. J Clin Lab Anal [Internet]. 2018 Sep [cited 2018 Dec 10];32(7):224–49. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/jcla.22449. 29603373

53. Mata AD, Marques D, Rocha S, Francisco H, Santos C, Mesquita MF, et al. Effects of diabetes mellitus on salivary secretion and its composition in the human. Mol Cell Biochem [Internet]. 2004 Jun [cited 2017 Apr 28];261(1):137–42. Available from: https://link.springer.com/article/10.1023/B:MCBI.0000028748.40917.6f.

54. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care? J Clin Invest [Internet]. 2004 Nov [cited 2017 Oct 12];114(9):1187–95. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524243/. doi: 10.1172/JCI23506 15520847

55. Montori VM, Bistrian BR.; McMahon MM. Hyperglycemia in Acutely Ill Patients. JAMA [Internet]. 2002 Nov [cited 2018 Abr 23];288(17):2167–69. Available from: https://jamanetwork.com/journals/jama/article-abstract/195453. doi: 10.1001/jama.288.17.2167 12413377

56. Inzucchi SE, Siegel MD. Glucose Control in the ICU–How Tight Is Too Tight? N Engl J Med [Internet]. 2009 Mar [cited 2018 Abr 23];360:1346–9. Available from: https://www.nejm.org/doi/full/10.1056/NEJMe0901507. 19318385

57. Critchell CD, Savarese V, Callahan A, Aboud C, Jabbour S, Marik P. Accuracy of bedside capillary blood glucose measurements in critically Ill patients. Intensive Care Med [Internet]. 2007 Dec [cited 2018 May 4];33(12):2079–84. Available from: https://link.springer.com/article/10.1007%2Fs00134-007-0835-4. doi: 10.1007/s00134-007-0835-4 17763842

58. Cook A, Laughlin D, Moore M, North D, Wilkins K, Wong G, et al. Differences in Glucose Values Obtained from Point-of-Care Glucose Meters and Laboratory Analysis in Critically Ill Patients. Am J Crit Care [Internet]. 2009 Jan [cited 2018 May 4];18(1):65–72. Available from: http://ajcc.aacnjournals.org/content/18/1/65.short. doi: 10.4037/ajcc2009626 19116407

59. Australian and New Zealand Intensive Care Society Clinical Trials Group; George Institute for International Health; Canadian Critical Care Trials Group; Vancouver Coastal Health Research Institute. Intensive versus Conventional Glucose Control in Critically Ill Patients. N Engl J Med [Internet]. 2009 Mar [cited 2018 Abr 23];360:1283–97. Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa0810625. 19318384

60. Brunner R, Adelsmayr G, Herkner H, Madl C, Holzinger U. Glycemic variability and glucose complexity in critically ill patients: a retrospective analysis of continuous glucose monitoring data. Crit Care. [Internet]. 2012 Out [cited 2018 May 4];16(5):R175. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682275/. doi: 10.1186/cc11657 23031322

61. Inoue S, Egi M, Kotani J, Morita K. Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review. Crit Care [Internet]. 2013 Mar [cited 2018 May 4];17(2):R48. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672636/. doi: 10.1186/cc12567 23506841

62. Diabetes in Control. A Summary of ADA’s New 2018 Standards of Medical Care in Diabetes [Internet]. [place unknown]: Diabetes in Control; 2017 Dec 16 [cited 2018 nov 12]. Available from: http://www.diabetesincontrol.com/a-summary-of-adas-new-2018-standards-of-medical-care-in-diabetes/.

63. American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes–2018. Diabetes Care [Internet]. 2018 Jan;41(Suppl 1):S13–S27 Available from: http://care.diabetesjournals.org/content/41/Supplement_1/S13.long. doi: 10.2337/dc18-S002 29222373

64. Krinsley JS. Effect of an Intensive Glucose Management Protocol on the Mortality of Critically Ill Adult Patients. Mayo Clin Proc [Internet]. 2004 Ago [cited 2018 Apr 23];79(8):992–1000. Available from: doi: 10.4065/79.8.992 15301325

65. Holzinger U, Warszawska J, Kitzberger R, Wewalka M, Miehsler W, Herkner H, et al. Real-Time continuous glucose monitoring in critically ill patients: a prospective randomized trial. Diabetes Care [Internet]. 2010 Mar [cited 2018 May 4];33(3):467–72. Available from: http://care.diabetesjournals.org/content/33/3/467.long. doi: 10.2337/dc09-1352 20007948

66. Wiener RS; Wiener DC, Larson RJ. Benefits and Risks of Tight Glucose Control in Critically Ill Adults: a Meta-analysis. JAMA [Internet]. 2008 Aug [cited 2018 Apr 23];300(8):933–44. Available from: https://jamanetwork.com/journals/jama/fullarticle/182432. doi: 10.1001/jama.300.8.933 18728267

67. Ichai C, Preiser JC; Société Française d'Anesthésie-Réanimation; Société de Réanimation de langue Française; Experts group. International recommendations for glucose control in adult non diabetic critically ill patients. Crit Care [Internet]. 2010 Set [cited 2018 May 10];14(5):R166. Available from: https://ccforum.biomedcentral.com/articles/10.1186/cc9258. 20840773

68. Darwazeh AM, MacFarlane TW, McCuish A, Lamey PJ. Mixed salivary glucose levels and candidal carriage in patients with diabetes mellitus. J Oral Pathol Med [Internet]. 1991 Jul [cited 2018 May 2];20(6):280–3. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0714.1991.tb00928.x?sid=nlm%3Apubmed. 1890663

69. Webster S, Todd S, Redhead J, Wright C. Lonised calcium levels in major trauma patients who received blood in the Emergency Department. Emerg Med J [Internet]. 2016 Aug [cited 2018 Sep 6];33(8):569–72. Available from: https://emj.bmj.com/content/33/8/569.long. doi: 10.1136/emermed-2015-205096 26848163

70. Chiappelli F, Iribarren FJ, Prolo P. Salivary biomarkers in psychobiological medicine. Bioinformation [Internet]. 2006 Dec 29 [cited 2018 Oct 20];1(8):331–4. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891707/. doi: 10.6026/97320630001331 17597915

71. Lima DP, Correia ASC, Anjos AL, Boer NP. [Use of saliva for diagnosis of oral and systemic diseases]. Rev Odontol Arac [Internet]. 2014 Jan-Jun [cited 2018 Dec 1];35(1):55–9. Available from: http://apcdaracatuba.com.br/revista/2014/10/v35n122014.htm. Portuguese.

72. Melo REVAM, Vitor CMA, Silva MBL, Luna LAL, Firmo ACB, Melo MMVA. [Hormonal answer in the polytraumatized patient]. Int J Dent [Internet]. 2005 Jan-Jun [cited 2018 Jul 22];4(1):31–6. Available from: https://periodicos.ufpe.br/revistas/dentistry/article/view/13844/16693. Portuguese.


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