Congenital Zika Syndrome in a Brazil-Paraguay-Bolivia border region: Clinical features of cases diagnosed between 2015 and 2018


Autoři: Fabio Antonio Venancio aff001;  Maria Eulina Quilião Bernal aff002;  Maria da Conceição de Barros Vieira Ramos aff003;  Neuma Rocha Chaves aff003;  Marcos Vinicius Hendges aff004;  Mattheus Marques Rodrigues de Souza aff004;  Márcio José de Medeiros aff005;  Cláudia Du Bocage Santos Pinto aff006;  Everton Falcão de Oliveira aff001
Působiště autorů: Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brasil aff001;  Centro Especializado em Reabilitação, Associação de Pais e Amigos dos Excepcionais, Campo Grande, Brasil aff002;  Coordenadoria de Vigilância Epidemiológica, Secretaria Municipal de Saúde Pública de Campo Grande, Campo Grande, Brasil aff003;  Faculdade de Medicina, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brasil aff004;  Universidade Federal do Rio de Janeiro, Campus Macaé, Rio de Janeiro, Brasil aff005;  Instituto Integrado de Saúde, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brasil aff006
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223408

Souhrn

Congenital Zika Syndrome (CZS) is a unique pattern of congenital abnormalities found in fetuses and neonates infected with the Zika virus (ZIKV). Here, we clinically identify and characterize infants with CZS between 2015 and 2018 in Mato Grosso do Sul, Brazil—a border area with Paraguay and Bolivia. This cross-sectional study, based on primary and secondary data, tracks the cases registered in the Brazilian Public Health Reporting System through the following stages: (1) preliminary data analysis, (2) identification of the congenital syndrome cases, (3) etiologic classification of the cases, (4) active search, and (5) clinical assessment. Of the 72 investigated cases, 16 were probable cases of CZS. Of these, it was only possible to clinically assess 11 infants. Considering the 16 probable cases of CZS, nine were classified as confirmed cases, and five as potential cases of the syndrome. Regarding clinical features, brain palsy was identified in all analyzed infants. Moreover, microcephaly and pseudobulbar syndrome were found in eight infants, and hydrocephalus was found in three individuals. In addition to these conditions, seven children were malnourished. Our study may provide significant insights for other researches that aim to elucidate CZS and its clinical and populational consequences.

Klíčová slova:

Brazil – Infants – Microcephaly – Pregnancy – Reverse transcriptase-polymerase chain reaction – Zika virus – Zika fever – Congenital anomalies


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