Remarkable cell recovery from cerebral ischemia in rats using an adaptive escalator-based rehabilitation mechanism

Autoři: Chi-Chun Chen aff001;  Yu-Lin Wang aff002;  Ching-Ping Chang aff005
Působiště autorů: Department of Electronic Engineering, National Chin-Yi University of Technology, Taichung, Taiwan aff001;  Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan aff002;  Center of General Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan aff003;  Department of Physical Medicine and Rehabilitation, Chi Mei Medical Center, Tainan, Taiwan aff004;  Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan aff005
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article


Currently, many ischemic stroke patients worldwide suffer from physical and mental impairments, and thus have a low quality of life. However, although rehabilitation is acknowledged as an effective way to recover patients’ health, there does not exist yet an adaptive training platform for animal tests so far. For this sake, this paper aims to develop an adaptive escalator (AE) for rehabilitation of rats with cerebral ischemia. Rats were observed to climb upward spontaneously, and a motor-driven escalator, equipped with a position detection feature and an acceleration/deceleration mechanism, was constructed accordingly as an adaptive training platform. The rehabilitation performance was subsequently rated using an incline test, a rotarod test, the infarction volume, the lesion volume, the number of MAP2 positive cells and the level of cortisol. This paper is presented in 3 parts as follows. Part 1 refers to the escalator mechanism design, part 2 describes the adaptive ladder-climbing rehabilitation mechanism, and part 3 discusses the validation of an ischemic stroke model. As it turned out, a rehabilitated group using this training platform, designated as the AE group, significantly outperformed a control counterpart in terms of a rotarod test. After the sacrifice of the rats, the AE group gave an average infarction volume of (34.36 ± 3.8)%, while the control group gave (66.41 ± 3.1)%, validating the outperformance of the escalator-based rehabilitation platform in a sense. An obvious difference between the presented training platform and conventional counterparts is the platform mechanism, and for the first time in the literature rats can be well and voluntarily rehabilitated at full capacity using an adaptive escalator. Taking into account the physical diversity among rats, the training strength provided was made adaptive as a reliable way to eliminate workout or secondary injury. Accordingly, more convincing arguments can be made using this mental stress-free training platform.

Klíčová slova:

Adaptive training – Animal performance – Cortisol – Ischemic stroke – Running – Surgical and invasive medical procedures – Neostriatum – Infarction


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