A novel radiopaque tissue marker for soft tissue localization and in vivo length and area measurements


Autoři: Sambit Sahoo aff001;  Andrew R. Baker aff001;  Bong Jae Jun aff001;  Ahmet Erdemir aff001;  Eric T. Ricchetti aff002;  Joseph P. Iannotti aff002;  Kathleen A. Derwin aff001
Působiště autorů: Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America aff001;  Department of Orthopaedic Surgery, Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio, United States of America aff002
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224244

Souhrn

Purpose

The purpose of the study was to describe the characteristics and demonstrate proof-of-concept and clinical use of a barium sulfate infused polypropylene radiopaque tissue marker for soft tissue localization and in vivo measurement of lengths and areas.

Methods

Marker mechanical properties were evaluated by tensile tests. Biocompatibility was evaluated following 8–12 weeks’ implantation in a pig model. Proof-of-concept of marker application was performed in a human cadaveric shoulder model, and methods for CT imaging and measurement of dimensions were established. Lastly, the method of clinical use of the markers was described in one patient undergoing arthroscopic rotator cuff repair (RCR).

Results

The radiopaque markers had a tensile strength of 28 ±4.7 N and were associated with minimal to mild inflammatory tissue reaction similar to polypropylene control. CT-based measurements showed relatively high precisions for lengths (0.66 mm), areas (6.97 mm2), and humeral orientation angles (2.1°) in the cadaveric model, and demonstrated 19 ±3 mm medio-lateral tendon retraction and 227 ±3 mm2 increase in tendon area in the patient during 26 weeks following RCR. No radiographic leaching, calcification or local adverse events were observed.

Conclusions

The radiopaque tissue marker was biocompatible and had adequate strength for handling and affixation to soft tissues using standard suturing techniques. The marker could be used with low-dose, sequential CT imaging to quantitatively measure rotator cuff tendon retractions with clinically acceptable accuracy. We envision the radiopaque tissue marker to be useful for soft tissue localization and in vivo measurement of tissue and organ dimensions following surgery.

Klíčová slova:

Biomaterial implants – Computed axial tomography – Humerus – Soft tissues – Surgical and invasive medical procedures – Surgical repair – Tendons – Tissue repair


Zdroje

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2019 Číslo 10