#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Use of acoustic emission to identify novel candidate biomarkers for knee osteoarthritis (OA)


Autoři: Daniela K. Schlüter aff001;  Lucy Spain aff003;  Wei Quan aff005;  Harry Southworth aff006;  Nicola Platt aff007;  Joe Mercer aff008;  Lik-Kwan Shark aff005;  John C. Waterton aff009;  Mike Bowes aff010;  Peter J. Diggle aff001;  Mandy Dixon aff007;  Jane Huddleston aff007;  John Goodacre aff003
Působiště autorů: CHICAS, Lancaster Medical School, Lancaster University, Lancaster, England, United Kingdom aff001;  Institute of Population Health Science, Liverpool University, Liverpool, England, United Kingdom aff002;  Faculty of Health and Medicine, Lancaster University, Lancaster, England, United Kingdom aff003;  Institute of Science, Natural Resources and Outdoor Studies, University of Cumbria, Carlisle, England, United Kingdom aff004;  Applied Digital Signal and Image Processing Research Centre, University of Central Lancashire, Preston, England, United Kingdom aff005;  Data Clarity Consulting Ltd, Altrincham, England, United Kingdom aff006;  Lancaster Health Hub, Lancaster University, Lancaster, England, United Kingdom aff007;  The Christie NHS Foundation Trust, Manchester, England, United Kingdom aff008;  Centre for Imaging Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, England, United Kingdom aff009;  Imorphics Ltd, Manchester, England, United Kingdom aff010
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223711

Souhrn

Our objective was to determine the efficacy and feasibility of a new approach for identifying candidate biomarkers for knee osteoarthritis (OA), based on selecting promising candidates from a range of high-frequency acoustic emission (AE) measurements generated during weight-bearing knee movement. Candidate AE biomarkers identified by this approach could then be validated in larger studies for use in future clinical trials and stratified medicine applications for this common health condition. A population cohort of participants with knee pain and a Kellgren-Lawrence (KL) score between 1-4 were recruited from local NHS primary and secondary care sites. Focusing on participants’ self-identified worse knee, and using our established movement protocol, sources of variation in AE measurement and associations of AE markers with other markers were explored. Using this approach we identified 4 initial candidate AE biomarkers, of which “number of hits” showed the best reproducibility, in terms of within-session, day to day, week to week, between-practitioner, and between-machine variation, at 2 different machine upper frequency settings. “Number of hits” was higher in knees with KL scores of 2 than in KL1, and also showed significant associations with pain in the contralateral knee, and with body weight. “Hits” occurred predominantly in 2 of 4 defined movement quadrants. The protocol was feasible and acceptable to all participants and professionals involved. This study demonstrates how AE measurement during simple sit-stand-sit movements can be used to generate novel candidate knee OA biomarkers. AE measurements probably reflect a composite of structural changes and joint loading factors. Refinement of the method and increasing understanding of factors contributing to AE will enable this approach to be used to generate further candidate biomarkers for validation and potential use in clinical trials.

Klíčová slova:

Acoustic signals – Biomarkers – Cartilage – Clinical trials – Knee joints – Knees – Musculoskeletal system – Osteoarthritis


Zdroje

1. NICE 2014. Osteoarthritis: Care and management in adults. http://guidance.nice.org.uk/CG177: National Institute for Health and Care Excellence 2014.

2. Hunter DJ, Guermazi A, Roemer F, Zhang Y and Neogi T. Structural correlates of pain in joints with osteoarthritis. Osteoarthritis Cartilage. 2013; 21: 1170–8. doi: 10.1016/j.joca.2013.05.017 23973127

3. BEST (Biomarkers, Endpoints and other Tools) Resource FDA-NIH Biomarker Working Group http://www.ncbi.nim.nih.gov/books/NBK338448/

4. Mascaro B, Prior J, Shark LK, Selfe J, Cole P and Goodacre J. Exploratory study of a noninvasive method based on acoustic emission for assessing the dynamic integrity of knee joints. Med. Eng. Phys. 2009; 31(8): 1103–1022.

5. Prior J, Mascaro B, Shark LK, Stockdale J, Selfe J, Bury R, et al. Analysis of high frequency acoustic emission signals as a new approach for assessing knee osteoarthritis. Ann. Rheum. Dis. 2010a; 69(5): 929–30

6. Prior J, Mascaro B, Shark L-K, Stockdale J, Selfe J, Bury R, Cole P and Goodacre J. Analysis of high frequency acoustic emission signals as a new approach for assessing knee osteoarthritis. Ann Rheum Dis 2010b; 69, 929–930.

7. Shark LK, Chen H and Goodacre J. Discovering differences in acoustic emission between healthy and osteoarthritic knees using a four-phase model of sit-stand-sit movements. Open Med Inform. J. 2010; 4: 116–125. doi: 10.2174/1874431101004010116 21379396

8. Shark LK, Chen H and Goodacre J. Knee acoustic emission: A potential biomarker for quantitative assessment of joint ageing and degeneration. Med. Eng. Phys. 2011; 33(5): 534–545 doi: 10.1016/j.medengphy.2010.12.009 21310645

9. Spain L, Rajoub B, Schlueter DK, Waterton J, Bowes M, Shark L-K, et al. Biomarkers for knee osteoarthritis: New technologies, new paradigms. International Journal of Clinical Rheumatology. 2015; Oct;10(4):287–297. Available from, doi: 10.2217/ijr.15.32

10. Balamoody S, Williams TG, Waterton JC, Bowes M, Hodgson R, Taylor CJ, et al. Comparison of 3T MR scanners in regional cartilage-thickness analysis in osteoarthritis: a cross-sectional multicenter, multivendor study. Arthritis Res Ther. 2010;12(5):R202. doi: 10.1186/ar3174 21029439

11. Cootes TF, Edwards GJ, Taylor CJ. Active Appearance Models. IEEE Trans Patt Anal Mach Intell 2001; Jun 1;23(6):681–5.

12. Wells JG, and Rawlings RD. Acoustic emission and mechanical properties of trabecular bone. Biomaterials. 1985: 6(4); 218–24. doi: 10.1016/0142-9612(85)90016-x 4052534

13. Singh VR Acoustical imaging techniques for bone studies. Applied Acoustics 1989; 27: 119–128

14. Shrivastava S. and Prakash R. Assessment of bone condition by acoustic emission technique: A review. Journal of Biomedical Science and Engineering 2009; 2: 144–154.

15. Schwalbe HJ, Bamfarte G and Franke RP. Non-destructive and non-invasive observation of friction and wear of human joints and of fracture initiation by acoustic emission. Proc Inst Mech Eng H 1999; 213(1): 41–8 doi: 10.1243/0954411991534799 10087903

16. Lu Q, Yadid-Pecht O, Sadowski D and Mintchev MP. Acoustic and Intraluminal Ultrasonic Technologies in the Diagnosis of Diseases in Gastrointestinal Tract: A Review. Engineering 5 (5B), 2013; 73–77.

17. Choi N-S, Gu J-U and Arakawa K. Acoustic emission characterisation of the marginal disintegration of dental composite restoration. Composites Part A: Applied Science and Manufacturing 2011; 42(6): 604–611

18. Cho NY, Ferracane JL and Lee IB. Acoustic emission analysis of tooth-composite interfacial debonding. J Dent Res. 2013; 92(1):76–81. doi: 10.1177/0022034512465757 23100273

19. Inan OT, Hersek S, Teague CT, Toreyin H, Jeong HK et al A stethoscope for the knee: Investigating joint acoustical emissions as novel biomarkers for wearable joint health assessment. Journal of the Acoustical Society of America 2016; 139: 2175 http://dx.doi.org/10.1121/1.4950462

20. Teague CN, Hersek S, Toreyin H, Millard-Stafford ML, Jones ML, Kogler GF et al Novel methods for sensing acoustical emissions from the knee for wearable joint health assessment. IEEE Trans Biomed Eng 2016; 63(8): 1581–90. doi: 10.1109/TBME.2016.2543226 27008656

21. Toreyin H, Jeong HK, Hersek S, Teague CN and Inan OT. Quantifying the consistency of wearable knee acoustical emission measurements during complex motions. IEEE J Biomed Health Inform 2016; 20(5): 1265–72: doi: 10.1109/JBHI.2016.2579610 27305689

22. Hersek S, Baran Pouyan M, Teague CN, Sawka MN, Millard-Stafford ML, Kogler GF et al Acoustical emission analysis by unsupervised graph mining: A novel biomarker of knee health status. IEEE Trans Biomed Eng 2017; 65(6): 1291–1300: doi: 10.1109/TBME.2017.2743562 28858782

23. Shakya B, Tiulpin A, Saarakkala S, Turunen S, and Thevenot J. Detection of experimental cartilage damage with acoustic emissions technique: An in vitro equine study. Equine Veterinary Journal April 2019 doi: 10.111/evj.13132

24. Kernohan WG, Beverland DE, McCoy GF, Shaw SN, Wallace RGH, McCullagh GC, Mollan RAB. The diagnostic potential of vibration arthrography. Clin Orthop. 1986;210:106–12.

25. Lee JH, Jiang CC, Yuan TT. Vibration arthrometry in patients with knee joint disorders. IEEE Trans Biomed Eng. 2000;47(8):1131–3. doi: 10.1109/10.855942 10943063

26. Krishnan S, Rangayyan RM, Bell GD, Frank CB, Ladly KO. Adaptive filtering, modelling and classification of knee joint vibroarthrographic signals for non-invasive diagnosis of articular cartilage pathology. Med Biol Eng Comput. 1997; 35:677–84. doi: 10.1007/bf02510977 9538545

27. Bergmann G, Bender A, Graichen F, Dymke J, Rohlmann A, Trepczynski A, et al Standardized loads acting in knee implants PLoS ONE 2014; 9(1): e86035. doi: 10.1371/journal.pone.0086035 24465856

28. Sibella F, Galli M, Romei M, Montesano A, Crivellini M. Biomechanical analysis of sit- to-stand movement in normal and obese subjects Clinical Biomechanics 2003; 18: 745–750 12957561

29. Turcot K, Armand S, Fritchy D, Hoffmayer P, Suva D. Sit-to-stand alterations in advanced knee osteoarthritis Gait Posture 2012 May;36(1):68–72. doi: 10.1016/j.gaitpost.2012.01.005 Epub 2012 Feb 9. 22326239

30. Duffell LD, Gulati V, Southgate DF, McGregor AH. Measuring body weight distribution during sit-to-stand in patients with early knee osteoarthritis. Gait and Posture. 2013; Sep;38(4):745–50. doi: 10.1016/j.gaitpost.2013.03.015 Epub 2013 Apr 15. 23597942

31. Case JP, Shakoor N, Baliunas A J, Block JA, Hurwitz DE Unilateral knee osteoarthritis, the relative overloading of the contralateral non-cognate joints and the relationship to pain 49th Annual Meeting of the Orthopaedic Research Society. 2003; Paper #0106

32. Shakoor N, Hurwitz DE, Block JA, Shott S, Case JP. Asymmetric knee loading in advanced unilateral hip osteoarthritis. Arthritis Rheum. 2003 Jun;48(6):1556–61. doi: 10.1002/art.11034 12794823

33. Niu J, Felson DT, Nevitt M, Aliabadi P, Lewis C, Sack B, et al; Pain in one knee increases the risk of tibiofemoral osteoarthritis in the contralateral knee: The MOST Study [abstract]. Arthritis Rheum 2009;60 Suppl 10:632 doi: 10.1002/art.25712

34. Metcalfe AJ, Stewart C, Postans N, Dodds AL, Holy CA, Roberts AP. The effect of osteoarthritis of the knee on the biomechanics of other joints in the lower limbs Bone Joint J 2013; 95-B:348–53

35. European Medicines Agency. Committee for medicinal products for human use. Draft guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis CPMP/EWP/784/97 Rev1. 2009 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC.500003443.pdf

36. U.S. Department of Health and Human Services Food and Drug Administration Center Draft Guidance for Industry: Clinical Development Programs for Drugs, Devices, and Biological Products Intended for the Treatment of Osteoarthritis (OA). 2016; https://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm071577.pdf


Článek vyšel v časopise

PLOS One


2019 Číslo 10
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

KOST
Koncepce osteologické péče pro gynekology a praktické lékaře
nový kurz
Autoři: MUDr. František Šenk

Sekvenční léčba schizofrenie
Autoři: MUDr. Jana Hořínková

Hypertenze a hypercholesterolémie – synergický efekt léčby
Autoři: prof. MUDr. Hana Rosolová, DrSc.

Svět praktické medicíny 5/2023 (znalostní test z časopisu)

Imunopatologie? … a co my s tím???
Autoři: doc. MUDr. Helena Lahoda Brodská, Ph.D.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#