The prevalence and risk of non-infectious comorbidities in HIV-infected and non-HIV infected men attending general practice in Australia


Autoři: Jack Edward Heron aff001;  Sarah M. Norman aff002;  Jeannie Yoo aff002;  Kirsty Lembke aff002;  Catherine C. O’Connor aff003;  Clare E. Weston aff002;  David M. Gracey aff001
Působiště autorů: Department of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia aff001;  NPS MedicineWise, Sydney, New South Wales, Australia aff002;  Kirby Institute, University of NSW, Sydney, New South Wales, Australia aff003;  Central Clinical School, University of Sydney, Sydney, New South Wales, Australia aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223224

Souhrn

Background

Non-AIDS-related mortality rates among HIV-infected patients still exceed those of their uninfected peers. A major driver of this excess mortality is a higher risk of non-infectious comorbidities, including cardiovascular disease, chronic kidney disease, type 2 diabetes mellitus, osteoporosis and cancer. The prevalence of mental illness and other chronic non-infectious comorbidities is identified as a primary concern of antiretroviral prescribers in Australia.

Methods

We conducted a cross-sectional, observational study using data from MedicineInsight, a large-scale Australian primary care database comprising longitudinal data from electronic clinical information systems. The HIV-infected cohort included all men with a recorded diagnosis of HIV. The non-HIV-infected cohort comprised all other men from the same practices. The prevalence and risk of cardiovascular disease, chronic kidney disease, type 2 diabetes mellitus, osteoporosis, cancer, anxiety and depression were compared between the groups.

Results

We included 2,406 HIV-infected males and 648,205 males with no record of HIV diagnosis attending primary care in this study. HIV-infected men were less socioeconomically disadvantaged and more urban-dwelling than men in the primary care cohort. We found that HIV-infected men attending primary care in Australia are at increased risk of chronic kidney disease, cancer, osteoporosis, anxiety and depression. There appears to be a risk of premature onset of cardiovascular disease, osteoporosis and cancer among younger HIV-infected patients. There is a high prevalence of anxiety and depression among HIV-infected men.

Conclusions

Increased prevalence of non-infectious comorbidities among HIV-infected men has broad implications for the effective management of those with these chronic conditions. Education to raise awareness among both HIV-infected men and their care providers, together with a greater focus on risk reduction, monitoring and preventive care, may be effective strategies in primary healthcare settings to further narrow the gap in health outcomes between people living with HIV and their uninfected counterparts.

Klíčová slova:

Age groups – Australia – Cardiovascular diseases – HIV diagnosis and management – HIV epidemiology – Chronic kidney disease – Osteoporosis – Primary care


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PLOS One


2019 Číslo 10

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