Health related quality of life in sepsis survivors from the Prehospital Antibiotics Against Sepsis (PHANTASi) trial


Autoři: R. S. Nannan Panday aff001;  T. C. Minderhoud aff001;  D. S. Chantalou aff001;  N. Alam aff001;  P. W. B. Nanayakkara aff001
Působiště autorů: Section Acute Medicine, Department of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands aff001;  Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands aff002;  Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands aff003
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222450

Souhrn

Background

Due to the rise in incidence, the long term effect of sepsis are becoming more evident. There is increasing evidence that sepsis may result in an impaired health related quality of life. The aim of this study was to investigate whether health related quality of life is impaired in sepsis survivors and which clinical parameters are associated with the affected health related quality of life.

Methods

We analyzed 880 Short Form 36 (SF-36) questionnaires that were sent to sepsis survivors who participated in the Prehospital Antibiotics Against Sepsis (PHANTASi) trial. These questionnaires were sent by email, 28 days after discharge. Data entry and statistical analyses were performed in SPSS. The data from the general Dutch population, was obtained from the Netherlands Cancer Institute (NKI-AVL) and served as a control group. Subsequently, 567 sepsis survivors were matched to 567 controls. Non-parametric Wilcoxon signed-rank test was performed to compare these two groups. Within the group, we sought to explain the diminished health related quality of life by factor analysis.

Results

We found that sepsis survivors have a worse health related quality of life compared to the general Dutch population. This negative effect was more evident for the physical component than the mental component of health related quality of life. We found that health related quality of life was significantly altered by advancing age and female sex. We also found that the total length of stay (in the hospital) and (previous) comorbidity negatively affect the physical component of health related quality of life.

Conclusion

In our study we found that health related quality of life in sepsis survivors, 28 days after discharge, is severely diminished in comparison with the general Dutch population. The physical domain is severely affected, whereas the mental domain is less influenced. The length of stay, comorbidity, advancing age and female sex all have a negative effect on the Physical Component Scale of the health related quality of life.

Klíčová slova:

Diabetes mellitus – Heart failure – Hospitals – Mental health and psychiatry – Quality of life – Questionnaires – Sepsis – Severe sepsis


Zdroje

1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–10. doi: 10.1001/jama.2016.0287. 26903338; PubMed Central PMCID: PMC4968574.

2. Alam N, Nannan Panday RS, Heijnen JR, van Galen LS, Kramer MHH, Nanayakkara PWB. Long-term health related quality of life in patients with sepsis after intensive care stay: A systematic review. Acute Med. 2017;16(4):164–9. 29300794.

3. Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. Am J Respir Crit Care Med. 2016;193(3):259–72. doi: 10.1164/rccm.201504-0781OC. 26414292.

4. Kadri SS, Rhee C, Strich JR, Morales MK, Hohmann S, Menchaca J, et al. Estimating Ten-Year Trends in Septic Shock Incidence and Mortality in United States Academic Medical Centers Using Clinical Data. Chest. 2017;151(2):278–85. doi: 10.1016/j.chest.2016.07.010. 27452768; PubMed Central PMCID: PMC5310115.

5. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304–77. doi: 10.1007/s00134-017-4683-6. 28101605.

6. Winters BD, Eberlein M, Leung J, Needham DM, Pronovost PJ, Sevransky JE. Long-term mortality and quality of life in sepsis: a systematic review. Crit Care Med. 2010;38(5):1276–83. doi: 10.1097/CCM.0b013e3181d8cc1d. 20308885.

7. Hofhuis JG, Spronk PE, van Stel HF, Schrijvers AJ, Rommes JH, Bakker J. The impact of severe sepsis on health-related quality of life: a long-term follow-up study. Anesth Analg. 2008;107(6):1957–64. doi: 10.1213/ane.0b013e318187bbd8. 19020144.

8. Cuthbertson BH, Elders A, Hall S, Taylor J, MacLennan G, Mackirdy F, et al. Mortality and quality of life in the five years after severe sepsis. Crit Care. 2013;17(2):R70. doi: 10.1186/cc12616. 23587132; PubMed Central PMCID: PMC4057306.

9. Heyland DK, Hopman W, Coo H, Tranmer J, McColl MA. Long-term health-related quality of life in survivors of sepsis. Short Form 36: a valid and reliable measure of health-related quality of life. Crit Care Med. 2000;28(11):3599–605. doi: 10.1097/00003246-200011000-00006 11098960.

10. Nesseler N, Defontaine A, Launey Y, Morcet J, Malledant Y, Seguin P. Long-term mortality and quality of life after septic shock: a follow-up observational study. Intensive Care Med. 2013;39(5):881–8. doi: 10.1007/s00134-013-2815-1. 23358541.

11. Groenewoudt M, Roest AA, Leijten FM, Stassen PM. Septic patients arriving with emergency medical services: a seriously ill population. Eur J Emerg Med. 2014;21(5):330–5. doi: 10.1097/MEJ.0000000000000091. 24185258.

12. Alam N, Oskam E, Stassen PM, Exter PV, van de Ven PM, Haak HR, et al. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med. 2018;6(1):40–50. doi: 10.1016/S2213-2600(17)30469-1. 29196046.

13. Alam N, de Ven PM, Oskam E, Stassen P, Kramer MH, Exter PV, et al. Study protocol for a Multi-centre, Investigator-initiated, Randomized Controlled Trial to Compare the Effects of Prehospital Antibiotic Treatment for Sepsis Patients with Usual Care after Training Emergency Medical Services (EMS) Personnel in Early Recognition (- The Prehospital ANTibiotics Against Sepsis (PHANTASi) trial. Acute Med. 2016;15(4):176–84. 28112286.

14. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31(4):1250–6. doi: 10.1097/01.CCM.0000050454.01978.3B. 12682500.

15. Ware JE Jr., Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473–83. 1593914.

16. Ware JE Jr. SF-36 health survey update. Spine (Phila Pa 1976). 2000;25(24):3130–9. doi: 10.1097/00007632-200012150-00008 11124729.

17. Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, et al. Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations. J Clin Epidemiol. 1998;51(11):1055–68. doi: 10.1016/s0895-4356(98)00097-3 9817123.

18. Ware JE, New England Medical Center Hospital. Health I. SF-36 physical and mental health summary scales: a user's manual. Boston :: Health Institute, New England Medical Center; 1994.

19. Hays RD, Sherbourne CD, Mazel RM. The RAND 36-Item Health Survey 1.0. Health Econ. 1993;2(3):217–27. 8275167.

20. Goulden R, Hoyle MC, Monis J, Railton D, Riley V, Martin P, et al. qSOFA, SIRS and NEWS for predicting inhospital mortality and ICU admission in emergency admissions treated as sepsis. Emerg Med J. 2018;35(6):345–9. doi: 10.1136/emermed-2017-207120. 29467173.

21. Walters SJ, Munro JF, Brazier JE. Using the SF-36 with older adults: a cross-sectional community-based survey. Age Ageing. 2001;30(4):337–43. doi: 10.1093/ageing/30.4.337 11509313.

22. Schwartz CE, Andresen EM, Nosek MA, Krahn GL, Measurement REPoHS. Response shift theory: important implications for measuring quality of life in people with disability. Arch Phys Med Rehabil. 2007;88(4):529–36. doi: 10.1016/j.apmr.2006.12.032. 17398257.

23. Granja C, Dias C, Costa-Pereira A, Sarmento A. Quality of life of survivors from severe sepsis and septic shock may be similar to that of others who survive critical illness. Crit Care. 2004;8(2):R91–8. doi: 10.1186/cc2818. 15025783; PubMed Central PMCID: PMC420036.

24. Needham DM, Wozniak AW, Hough CL, Morris PE, Dinglas VD, Jackson JC, et al. Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med. 2014;189(10):1214–24. doi: 10.1164/rccm.201401-0158OC. 24716641; PubMed Central PMCID: PMC4061900.

25. Brower RG. Consequences of bed rest. Crit Care Med. 2009;37(10 Suppl):S422–8. doi: 10.1097/CCM.0b013e3181b6e30a. 20046130.

26. Charafeddine R, Demarest S, Cleemput I, Van Oyen H, Devleesschauwer B. Gender and educational differences in the association between smoking and health-related quality of life in Belgium. Prev Med. 2017;105:280–6. doi: 10.1016/j.ypmed.2017.09.016. 28964851.

27. Choo J, Jeon S, Lee J. Gender differences in health-related quality of life associated with abdominal obesity in a Korean population. BMJ Open. 2014;4(1):e003954. doi: 10.1136/bmjopen-2013-003954. 24464522; PubMed Central PMCID: PMC3902435.

28. Gijsberts CM, Agostoni P, Hoefer IE, Asselbergs FW, Pasterkamp G, Nathoe H, et al. Gender differences in health-related quality of life in patients undergoing coronary angiography. Open Heart. 2015;2(1):e000231. doi: 10.1136/openhrt-2014-000231. 26339493; PubMed Central PMCID: PMC4555073.

29. Hajian-Tilaki K, Heidari B, Hajian-Tilaki A. Are Gender Differences in Health-related Quality of Life Attributable to Sociodemographic Characteristics and Chronic Disease Conditions in Elderly People? Int J Prev Med. 2017;8:95. doi: 10.4103/ijpvm.IJPVM_197_16. 29184646; PubMed Central PMCID: PMC5686916.

30. Davydow DS, Hough CL, Langa KM, Iwashyna TJ. Symptoms of depression in survivors of severe sepsis: a prospective cohort study of older Americans. Am J Geriatr Psychiatry. 2013;21(9):887–97. doi: 10.1016/j.jagp.2013.01.017 10.1097/JGP.0b013e31825c0aed. 23567391; PubMed Central PMCID: PMC3462893.

31. van den Boogaard M, Schoonhoven L, Evers AW, van der Hoeven JG, van Achterberg T, Pickkers P. Delirium in critically ill patients: impact on long-term health-related quality of life and cognitive functioning. Crit Care Med. 2012;40(1):112–8. doi: 10.1097/CCM.0b013e31822e9fc9. 21926597.

32. Redekop WK, Koopmanschap MA, Stolk RP, Rutten GE, Wolffenbuttel BH, Niessen LW. Health-related quality of life and treatment satisfaction in Dutch patients with type 2 diabetes. Diabetes Care. 2002;25(3):458–63. doi: 10.2337/diacare.25.3.458 11874930.

33. Glasgow RE, Ruggiero L, Eakin EG, Dryfoos J, Chobanian L. Quality of life and associated characteristics in a large national sample of adults with diabetes. Diabetes Care. 1997;20(4):562–7. doi: 10.2337/diacare.20.4.562 9096981.

34. Goldney RD, Phillips PJ, Fisher LJ, Wilson DH. Diabetes, depression, and quality of life: a population study. Diabetes Care. 2004;27(5):1066–70. doi: 10.2337/diacare.27.5.1066 15111522.

35. Tiru B, DiNino EK, Orenstein A, Mailloux PT, Pesaturo A, Gupta A, et al. The Economic and Humanistic Burden of Severe Sepsis. Pharmacoeconomics. 2015;33(9):925–37. doi: 10.1007/s40273-015-0282-y. 25935211.

36. Paratz JD, Kenardy J, Mitchell G, Comans T, Coyer F, Thomas P, et al. IMPOSE (IMProving Outcomes after Sepsis)-the effect of a multidisciplinary follow-up service on health-related quality of life in patients postsepsis syndromes-a double-blinded randomised controlled trial: protocol. BMJ Open. 2014;4(5):e004966. doi: 10.1136/bmjopen-2014-004966. 24861549; PubMed Central PMCID: PMC4039866.

37. Heyland DK, Groll D, Caeser M. Survivors of acute respiratory distress syndrome: relationship between pulmonary dysfunction and long-term health-related quality of life. Crit Care Med. 2005;33(7):1549–56. doi: 10.1097/01.ccm.0000168609.98847.50 16003061.

38. Dhingra SS, Strine TW, Holt JB, Berry JT, Mokdad AH. Rural-urban variations in psychological distress: findings from the Behavioral Risk Factor Surveillance System, 2007. Int J Public Health. 2009;54 Suppl 1:16–22. doi: 10.1007/s00038-009-0002-5. 19363589.

39. Perkins JJ, Sanson-Fisher RW. An examination of self- and telephone-administered modes of administration for the Australian SF-36. J Clin Epidemiol. 1998;51(11):969–73. doi: 10.1016/s0895-4356(98)00088-2 9817114.

40. Lyons RA, Wareham K, Lucas M, Price D, Williams J, Hutchings HA. SF-36 scores vary by method of administration: implications for study design. J Public Health Med. 1999;21(1):41–5. 10321858.

41. Oeyen SG, Vandijck DM, Benoit DD, Annemans L, Decruyenaere JM. Quality of life after intensive care: a systematic review of the literature. Crit Care Med. 2010;38(12):2386–400. doi: 10.1097/CCM.0b013e3181f3dec5. 20838335.

42. Myhren H, Ekeberg O, Stokland O. Health-related quality of life and return to work after critical illness in general intensive care unit patients: a 1-year follow-up study. Crit Care Med. 2010;38(7):1554–61. Epub 2010/05/18. doi: 10.1097/CCM.0b013e3181e2c8b1. 20473149.

43. Gerth AMJ, Hatch RA, Young JD, Watkinson PJ. Changes in health-related quality of life after discharge from an intensive care unit: a systematic review. Anaesthesia. 2019;74(1):100–8. Epub 2018/10/07. doi: 10.1111/anae.14444. 30291744; PubMed Central PMCID: PMC6586053.


Článek vyšel v časopise

PLOS One


2019 Číslo 10

Nejčtenější v tomto čísle

Tomuto tématu se dále věnují…


Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

Léčba bolesti v ordinaci praktického lékaře
nový kurz
Autoři: MUDr. PhDr. Zdeňka Nováková, Ph.D.

Revmatoidní artritida: včas a k cíli
Autoři: MUDr. Heřman Mann

Jistoty a nástrahy antikoagulační léčby aneb kardiolog - neurolog - farmakolog - nefrolog - právník diskutují
Autoři: doc. MUDr. Štěpán Havránek, Ph.D., prof. MUDr. Roman Herzig, Ph.D., doc. MUDr. Karel Urbánek, Ph.D., prim. MUDr. Jan Vachek, MUDr. et Mgr. Jolana Těšínová, Ph.D.

Léčba akutní pooperační bolesti
Autoři: doc. MUDr. Jiří Málek, CSc.

Nové antipsychotikum kariprazin v léčbě schizofrenie
Autoři: prof. MUDr. Cyril Höschl, DrSc., FRCPsych.

Všechny kurzy
Kurzy Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Nemáte účet?  Registrujte se

Zapomenuté heslo

Zadejte e-mailovou adresu se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se