#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Iodine supplementation of lactating women and assessment of infant visual information processing and maternal and infant thyroid function: A randomized trial


Autoři: Tafere Gebreegziabher aff001;  Tesfaye Woltamo aff002;  David G. Thomas aff003;  Tay S. Kennedy aff004;  Barbara J. Stoecker aff004
Působiště autorů: Department of Health Sciences, Central Washington University, Ellensburg, WA, United States of America aff001;  School of Environment, Gender, and Development Studies, Hawassa University, Hawassa, Ethiopia aff002;  Department of Psychology, Oklahoma State University, Stillwater, OK, United States of America aff003;  Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United States of America aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223348

Souhrn

Iodine deficiency is one of the major causes of brain damage in childhood. However, iodine supplementation during early pregnancy and lactation can prevent the ill effects of iodine deficiency. This study evaluated maternal and infant thyroid function and infant visual information processing (VIP) in the context of maternal iodine supplementation. A community-based, randomized, supplementation trial was conducted. Mother infant dyads (n = 106) were enrolled within the first 10 days after delivery to participate in this study. Mothers were randomly assigned either to receive a potassium iodide capsule (225 μg iodine) daily for 26 weeks or iodized salt weekly for 26 weeks. Maternal thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone (TSH), thyroglobulin (Tg), urinary iodine concentration (UIC), breast milk iodine concentration (BMIC) and infant T4, TSH, UIC and VIP were measured as outcome variables. At baseline, neither mothers nor infants in the two groups were significantly different in any of the biomarkers or anthropometric measurements. Maternal TSH and goiter prevalence significantly decreased following iodine supplementation. The percentage of infants who preferentially remembered the familiar face was 26% in the capsule and 51% in the I-salt groups. Infant sex, length for age Z score, BMIC, maternal education and household food security were strong predictors of novelty quotient. In conclusion supplementation daily for six months with an iodine capsule or the use of appropriately iodized salt for an equivalent time was sufficient to reduce goiter and TSH in lactating women. Higher BMIC and LAZ as well as better household food security, maternal education, and male sex predicted higher novelty quotient scores in the VIP paradigm.

Klíčová slova:

Anthropometry – Biomarkers – Infants – Iodine – Micronutrient deficiencies – Thyroid – Thyroid hormones – Thyroid-stimulating hormone


Zdroje

1. Chan S, Kilby MD. Thyroid hormone and central nervous system development. J Endocrinol. 2000; 165:1–8. doi: 10.1677/joe.0.1650001 10750030

2. WHO: Iodine status worldwide. WHO global database on iodine deficiency. Genenva: WHO 2004:1–58 (www.whqlibdoc.who.int/publication/2004/9241592001.pdf).

3. Zimmermann MB. The effects of iodine deficiency in pregnancy and infancy. Paediatr Perinat Epidemiol. 2012; 26:108–117. doi: 10.1111/j.1365-3016.2012.01275.x 22742605

4. WHO/UNICEF/ICCIDD: Assessment of iodine deficiency disorders and monitoring their elimination. a guide for program managers. Third edition. World Health Organization 2007.

5. Dold S, Zimmermann MB, Jukic T, Kusic Z, Jia Q, Sang Z, et al. Universal salt iodization provides sufficient dietary iodine to achieve adequate iodine nutrition during the first 1000 days: A cross-sectional multicenter study. J Nutr. 2018; 148(4):587–598. doi: 10.1093/jn/nxy015 29659964

6. Robinson SM, Crozier SR, Miles EA, Gale CR, Calder PC, Cooper C, et al. Preconception maternal iodine status is positively associated with IQ but not with measures of executive function in childhood. J Nutr. 2018; 148:959–966. doi: 10.1093/jn/nxy054 29767745

7. Pearce EN, Andersson M, Zimmermann MB. Global iodine nutrition: Where do we stand in 2013? Thyroid. 2013; 23(5):523–528. doi: 10.1089/thy.2013.0128 23472655

8. Vongchana M, Ounjaijean S, Tongsong T, Traisrisilp K. The effectiveness of iodine supplementation during pregnancies in geographical areas of high prevalence of iodine insufficiency. J Obstet Gynaecol. 2018; 38(6):756–761. doi: 10.1080/01443615.2017.1410534 29526129

9. Andersson M, de Benoist B, Delange F, Zupan J. Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation. Public Health Nutr. 2007; 10(12A):1606–1611. doi: 10.1017/S1368980007361004 18053287

10. Zimmermann MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr. 2009; 89 (suppl):668S–672S.

11. Vejbjerg P, Knudsen N, Perrild H, Carle A, Laurberg P, Pedersen IB, et al. Effect of a mandatory iodization program on thyroid gland volume based on individuals' age, gender, and preceding severity of dietary iodine deficiency: a prospective, population-based study. J Clin Endocrinol Metab. 2007; 92(4):1397–1401. doi: 10.1210/jc.2006-2580 17264188

12. Gebreegziabher T, Stoecker BJ. Comparison of two sources of iodine delivery on breast milk iodine and maternal and infant urinary iodine concentrations in southern Ethiopia: A randomized trial. Food Sci Nutr. 2017; 5(4):921–928. doi: 10.1002/fsn3.477 28748081

13. Ethiopian Public Health Institute: National salt iodization coverage towards prevention of iodine deficiency disorders in Ethiopia. 2014.

14. Abebe Y, Bogale A, Hambidge KM, Stoecker BJ, Bailey K, Gibson RS. Phytate, zinc, iron and calcium content of selected raw and prepared foods consumed in rural Sidama, Southern Ethiopia, and implications for bioavailability. J Food Comp Anal. 2007; 20:161–168.

15. Bogale A, Abebe Y, Stoecker BJ, Abuye C, Ketema K, Hambidge KM. Iodine status and cognitive function of women and their five year-old children in rural Sidama, southern Ethiopia. East Afr J Public Health. 2009; 6:296–299. 20803922

16. Ersino G, Tadele H, Bogale A, Abuye C, Stoecker BJ. Clinical assessment of goiter and low urinary iodine concentration depict presence of severe iodine deficiency in pregnant Ethiopian women: a cross-sectional study in rural Sidama, southern Ethiopia. Ethiop Med J. 2013; 51(2):133–141. 24079157

17. Gebreegziabher T, Teyike N, Mulugeta A, Abebe Y, Hambidge KM, Stoecker BJ. Lack of dietary sources of iodine and the prevalence of iodine deficiency in rural women from Sidama zone, southern Ethiopia. Afr J Food Agric Nutr Dev. 2013; 13:8401–8414.

18. Abuye C, Berhane Y, Akalu G, Getahun Z, Ersumo T. Prevalence of goiter in children 6 to 12 years of age in Ethiopia. Food Nutr Bull. 2007; 28:391–397. doi: 10.1177/156482650702800403 18274165

19. Central Statistical Agency and ORC Macro: Ethiopian demographic and health survey. Central Statistical Agency Addis Ababa, Ethiopia. 2005.

20. Coates J, Swindale A, Blinsky P: Household food insecurity access scale (HFIAS) for measurement of household food access: Indicator guide (v.3). Washington D.C: Food and Nutrition Technical Assistance Project, Academy for Educational Development. 2007.

21. Kennedy T, Thomas DG, Woltamo T, Abebe Y, Hubbs-Tait L, Sykova S, et al. Growth and visual information processing in infants in Southern Ethiopia. J Appl Dev Psychol. 2008; 29(2):129–140. doi: 10.1016/j.appdev.2007.12.003 19684873

22. Rose SA, Feldman JF, Jankowski JJ. Infant visual recognition memory. Dev Rev. 2004; 24:74–100.

23. Colombo J, Shaddy JD, Richman AW, Maikranz MJ, Blaga MO. The developmental course of habituation in infancy and preschool outcome. Infancy 2004; 5:1–38.

24. Courage LM, Howe LM, Squires ES. Individual differences in 3.5-month-olds' visual attention: what do they predict at 1 year? Infant Behav Dev. 2004; 27:19–30.

25. Susel A: Multiple classification analysis: Theory and application to demography. Department of quanatitative methods in management, Nowy Sacz School of Business-National Luise University 2011.

26. Girma M, Loha E, Bogale A, Teyike N, Abuye C, Stoecker BJ. Iodine deficiency in primary school children and knowledge of iodine deficiency and iodized salt among caretakers in Hawassa town: Southern Ethiopia. Ethiop J Health Dev. 2012; 26:30–35.

27. Santiago P, Velasco I, Muela JA, Sanchez B, Martinez J, Rodriguez A, et al. Infant neurocognitive development is independent of the use of iodised salt or iodine supplements given during pregnancy. Br J Nutr. 2013; 110(5):831–839. doi: 10.1017/S0007114512005880 23375074

28. Velasco I, Carreira M, Santiago P, Muela JA, Garcia-Fuentes E, Sanchez-Munoz B, et al. Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. J Clin Endocrinol Metab. 2009, 94(9):3234–3241. doi: 10.1210/jc.2008-2652 19567536

29. Delange F. Optimal iodine nutrition during pregnancy, lactation and the neonatal period. Int J Endocrinol Metab. 2004; 2:1–12.

30. Bouhouch RR, Bouhouch S, Cherkaoui M, Aboussad A, Stinca S, Haldimann M, et al. Direct iodine supplementation of infants versus supplementation of their breastfeeding mothers: a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol. 2014; 2(3):197–209. doi: 10.1016/S2213-8587(13)70155-4 24622750

31. Zimmermann MB. The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review. Thyroid. 2007; 17(9):829–835. doi: 10.1089/thy.2007.0108 17956157

32. Antonangeli L, Maccherini D, Cavaliere R, Di Giulio C, Reinhardt B, Pinchera A, et al. Comparison of two different doses of iodide in the prevention of gestational goiter in marginal iodine deficiency: a longitudinal study. Eur J Endocrinol. 2002; 147(1):29–34. doi: 10.1530/eje.0.1470029 12088916

33. Pedersen KM, Laurberg P, Iversen E, Knudsen PR, Gregersen HE, Rasmussen OS, et al. Amelioration of some pregnancy-associated variations in thyroid function by iodine supplementation. J Clin Endocrinol Metab. 1993; 77(4):1078–1083. doi: 10.1210/jcem.77.4.8408456 8408456

34. Rohner F, Zimmermann MB, Jooste P, Pandav C, Caldwell K, Raghavan R, et al. Biomarkers of nutrition for development—iodine review. J Nutr. 2014; 144(8):1322S–1342S. doi: 10.3945/jn.113.181974 24966410

35. Zimmermann MB, Aeberli I, Andersson M, Assey V, Yorg JA, Jooste P, et al. Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100–299 mug/L: a UNICEF/ICCIDD study group report. J Clin Endocrinol Metab. 2013; 98(3):1271–1280. doi: 10.1210/jc.2012-3952 23345097

36. Ghirri P, Lunardi S, Boldrini A: Iodine supplementation in the newborn. Nutrients 2014; 6(1):382–390. doi: 10.3390/nu6010382 24448111

37. Zimmermann MB, Adou P, Torresani T, Zeder C, Hurrell R: Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Cote d'Ivoire. Am J Clin Nutr. 2000; 71(1):88–93. doi: 10.1093/ajcn/71.1.88 10617951

38. Lazarus JH, Parkes AB, John R, N'Diaye M, Prysor-Jones SG. Endemic goitre in Senegal—thyroid function etiological factors and treatment with oral iodized oil. Acta Endocrinol. 1992; 126(2):149–154. doi: 10.1530/acta.0.1260149 1543020

39. de Escobar GM, Obregon MJ, del Rey FE. Iodine deficiency and brain development in the first half of pregnancy. Public Health Nutr. 2007; 10(12A):1554–1570. doi: 10.1017/S1368980007360928 18053280

40. Melse-Boonstra A, Gowachirapant S, Jaiswal N, Winichagoon P, Srinivasan K, Zimmermann MB. Iodine supplementation in pregnancy and its effect on child cognition. J Trace Elem Med Biol. 2012; 26(2–3):134–136. doi: 10.1016/j.jtemb.2012.03.005 22575544

41. Vermiglio F, Lo Presti VP, Moleti M, Sidoti M, Tortorella G, Scaffidi G, et al. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab. 2004; 89(12):6054–6060. doi: 10.1210/jc.2004-0571 15579758

42. Rose SA, Feldman FJ, Jankowski JJ. Infant visual recognition memory. Dev Rev. 2003; 24:74–100.

43. Colombo J, Wayne DM. Infant visual habituation. Neurobiol Learn Mem. 2009, 92:225–234. doi: 10.1016/j.nlm.2008.06.002 18620070

44. Oakes LM, Kovack-Lesh KA. Infants' visual recognition memory for a series of categorically related items. J Cogn Dev. 2013; 4(1):63–86. doi: 10.1080/15248372.2011.645971 23495291

45. Colombo J, Kannass NK, Shady JD, Kundurthi S, Maikranz MJ, Anderson JC, et al. Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev. 2004; 75:1254–1267. doi: 10.1111/j.1467-8624.2004.00737.x 15260876

46. Jacobson SW, Jacobson JL, Sokol RJ, Martier SS, Ager JW. Prenatal alcohol exposure and infant information processing ability. Child Dev. 1993; 64(6):1706–1721. 8112114

47. Jacobson SW, Jacobson JL, Sokol RJ, Martier SS, Chiodo LM. New evidence for neurobehavioral effects of in utero cocaine exposure. J Pediatr. 1996; 129:581–590. doi: 10.1016/s0022-3476(96)70124-5 8859266

48. Bautista A, Baker AP, Dunn TJ, Sanchez M, Kaiser LD. The effects of oral iodized oil on intellignece, thyroid status, and somatic growth in shcool-age children from an area of endemic goiter. Am J Clin Nutr. 1982; 35:127–134. doi: 10.1093/ajcn/35.1.127 6278919

49. Murcia M, Rebagliato M, Iniguez C, Lopez-Espinosa MJ, Estarlich M, Plaza B, et al. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. Am J Epidemiol. 2011; 173(7):804–812. doi: 10.1093/aje/kwq424 21385833

50. Perkins JM, Kim R, Krishna A, McGovern M, Aguayo VM, Subramanian SV: Understanding the association between stunting and child development in low- and middle-income countries: Next steps for research and intervention. Soc Sci Med. 2017; 193:101–109. doi: 10.1016/j.socscimed.2017.09.039 29028557

51. Helmizar H, Jalal F, Lipoeto NI, Achadi EL: Local food supplementation and psychosocial stimulation improve linear growth and cognitive development among Indonesian infants aged 6 to 9 months. Asia Pac J Clin Nutr. 2017; 26(1):97–103. doi: 10.6133/apjcn.102015.10 28049268

52. Zimmermann MB, KÖhrele J. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid. 2002; 12 (10):867–78. doi: 10.1089/105072502761016494 12487769


Článek vyšel v časopise

PLOS One


2019 Číslo 10
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

KOST
Koncepce osteologické péče pro gynekology a praktické lékaře
nový kurz
Autoři: MUDr. František Šenk

Sekvenční léčba schizofrenie
Autoři: MUDr. Jana Hořínková

Hypertenze a hypercholesterolémie – synergický efekt léčby
Autoři: prof. MUDr. Hana Rosolová, DrSc.

Svět praktické medicíny 5/2023 (znalostní test z časopisu)

Imunopatologie? … a co my s tím???
Autoři: doc. MUDr. Helena Lahoda Brodská, Ph.D.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#