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Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents


Autoři: Martin Šťastný aff001;  Václav Štengl aff001;  Irena Štenglová-Netíková aff002;  Michaela Šrámová-Slušná aff001;  Pavel Janoš aff003
Působiště autorů: Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic aff001;  1st Faculty of Medicine, Charles University in Prague, Ovocný trh, Czech Republic aff002;  Faculty of the Environment, J.E.Purkyně University in Ústí nad Labem, Ústí nad Labem, Czech Republic aff003
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223117

Souhrn

Anthracyclines are a class of pharmaceuticals used in cancer treatment have the potential to negatively impact the environment. To study the possibilities of anthracyclines (represented by pirarubicin and valrubicin) removal, chemical inactivation using NaOH (0.01 M) and NaClO (5%) as decontamination agents and adsorption to powdered nanocrystalline titanium dioxide (TiO2) were compared. The titanium dioxide (TiO2) nanoparticles were prepared via homogeneous precipitation of an aqueous solution of titanium (IV) oxy-sulfate (TiOSO4) at different amount (5–120 g) with urea. The as-prepared TiO2 samples were characterized by XRD, HRSEM and nitrogen physisorption. The adsorption process of anthracycline cytostatics was determined followed by high-performance liquid chromatography coupled with mass spectrometry (LC-MS) and an in-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) technique. It was found that NaClO decomposes anthracyclines to form various transformation products (TPs). No TPs were identified after the reaction of valrubicin with a NaOH solution as well as in the presence of TiO2 nanoparticles. The best degree of removal, 100% of pirarubicin and 85% of valrubicin, has been achieved in a sample with 120 grams of TiOSO4 (TIT120) and TiO2 with 60 grams (TIT60), respectively.

Klíčová slova:

Adsorption – High performance liquid chromatography – Chemical precipitation – Liquid chromatography-mass spectrometry – Nanomaterials – Nanoparticles – Titanium – Cytostatics


Zdroje

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