Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007

Autoři: Jian-Te Lee aff001;  Ting-Yu Yen aff002;  Wei-Liang Shih aff003;  Chun-Yi Lu aff002;  Ding-Ping Liu aff004;  Yi-Chuan Huang aff006;  Luan-Yin Chang aff002;  Li-Min Huang aff002;  Tzou-Yien Lin aff007
Působiště autorů: Department of Pediatrics, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan aff001;  Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan aff002;  Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University and Infectious Diseases Research and Education Center, Ministry of Health and Welfare and National Taiwan University, Taipei, Taiwan aff003;  Epidemic Intelligence Center, Centers for Disease Control, Taipei, Taiwan aff004;  National Taipei University of Nursing and Health Sciences, Taipei, Taiwan aff005;  Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan aff006;  Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan aff007;  The National Health Research Institutes, Miaoli, Taiwan aff008
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224110



During recent 20 years, enterovirus 71 (EV71) has emerged as a major concern among children, particularly in the Asia-Pacific region. To understand current EV71 serostatus, to find risk factors associated with EV71 infection and to establish future EV71 vaccine policy, we performed a seroepidemiology study in Taiwan in 2017.


After informed consent was obtained, we enrolled preschool children, 6–15-year-old students, 16–50-year-old people. They received a questionnaire and a blood sample was collected to measure the EV71 neutralization antibody.


Altogether, 920 subjects were enrolled with a male-to-female ratio of 1.03. The EV71 seropositive rate was 10% (8/82) in infants, 4% (6/153) in 1-year-old children, 8% (7/83) in 2-year-old children, 8% (13/156) in 3–5-year-old children, 31% (38/122) in 6–11-year-old primary school students, 45% (54/121) in 12–15-year-old high school students and 75% (152/203) in 16-50-year-old people. Risk factors associated with EV71 seropositivity in preschool children were female gender, having siblings, more siblings, and contact with herpangina or hand-foot-and-mouth disease. The risk factor with EV71 seropositivity in 16–50-year-old people was having children in their families in addition to older age (p<0.001). Compared with the rates in 1997, 1999 and 2007, the rates in children were significantly lower in 2017.


EV71 seropositive rates were very low, at 4% to 10%, in preschool children and not high, at 31%, in primary school students. Preschool children are highly susceptible and need EV71 vaccine most.

Klíčová slova:

Human families – Children – Medical risk factors – Rural areas – Schools – Taiwan – Urban areas – Hand, foot and mouth disease


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2019 Číslo 10