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Clinical and laboratorial profiles of dengue virus infection in kidney transplant recipients: Report of a single center


Autoři: Ida Maria Maximina Fernandes-Charpiot aff001;  Cassia Fernanda Estofolete aff002;  Heloisa Cristina Caldas aff001;  Gabriela Rodrigues de Souza aff001;  Rita de Cássia Martins Alves da Silva aff001;  Maria Alice Sperto Ferreira Baptista aff001;  Mauricio Lacerda Nogueira aff002;  Mario Abbud-Filho aff001
Působiště autorů: Kidney Transplant Unit, Faculty of Medicine of São José do Rio Preto, FAMERP—Hospital de Base São José do Rio Preto, São José do Rio Preto, Brazil aff001;  Laboratory of Research in Virology, Faculty of Medicine of São José do Rio Preto, FAMERP, São José do Rio Preto, Brazil aff002;  Instituto de Urology e Nefrologia, São José do Rio Preto, Brazil aff003
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0219117

Souhrn

Dengue infection (DI) is the most important arboviral infection in the world. The majority of immunocompetent patients will have asymptomatic or mild infections, but the degree of dengue severity in kidney transplant recipients (KTx) is unknown. In this study, we report the clinical profile and outcomes of 39 dengue cases in KTx. From a total of 1,186 KTx outpatients in follow-up we reviewed clinical and laboratory records of 60 (5%) patients admitted with suspected DI initially screened by NS-1, IgM, and when possible, multiplex nested PCR. The prevalence of DI in KTx was 3% (39/1,118), with symptoms leading to hospital admission being fever, myalgia, malaise, and headache. Laboratory tests showed leucopenia, thrombocytopenia, and liver enzyme elevation. DI was confirmed by positivity of NS-1 (33%), IgM (69%), and/or RT-PCR (59%). Twenty-three patients (59%) had dengue with warning signs, and 15% had severe dengue, 2 of them with a fatal course. Acute graft dysfunction occurred in 59% (mean nadir serum creatinine: 2.9 ± 2.6mg/dL), 4 of them requiring dialysis. CMV coinfection diagnosed in 19% of the cases and patients was associated with worse clinical presentation. Our results suggest that KTx with DI presented initial physical and laboratorial profile similar to the general population. However, DI in KTx seems to have a higher risk for graft dysfunction, severe dengue, and death. Because CMV coinfection aggravates the DI clinical presentation and recovery, it must be evaluated in all cases.

Klíčová slova:

Brazil – Co-infections – Creatinine – Cytomegalovirus infection – Human cytomegalovirus – Reverse transcriptase-polymerase chain reaction – Serology – Arboviral infections


Zdroje

1. Gubler DJ. Resurgent vector-borne diseases as a global health problem. Emerg Infect Dis. 1998;4(3):442–450. doi: 10.3201/eid0403.980326 9716967

2. Guha-Sapir D, Schimmer B. Dengue fever: new paradigms for a changing epidemiology. Emerg Themes Epidemiol. 2005;2(1):1. doi: 10.1186/1742-7622-2-1 15743532

3. Bandyopadhyay S, Lum LC, Kroeger A. Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever. Trop Med Int Health. 2006;11(8):1238–1255. doi: 10.1111/j.1365-3156.2006.01678.x 16903887

4. Figueiredo LT. The Brazilian flaviviruses. Microbes Infect. 2000;2(13):1643–1649. 11113383

5. Gubler DJ. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002;10(2):100–103. doi: 10.1016/s0966-842x(01)02288-0 11827812

6. De Simone TS, Nogueira RM, Araújo ES, Souza RV, Teixeira Filho G, Schatzmayr HG, et al. Dengue virus surveillance: the co-circulation of DENV-1, DENV-2 and DENV-3 in the State of Rio de Janeiro, Brazil. Trans R Soc Trop Med Hyg. 2004;98(9):553–562. doi: 10.1016/j.trstmh.2003.09.003 15251405

7. Brasil. Boletim epidemiológico. Monitoramento dos casos de dengue, febre de chikungunya e febre pelo Zika até a semana epidemiológica 52, 2017. Brasilia: Ministerio da Saude; 2018.

8. Mondini A, Cardeal IL, Lazaro E, Nunes SH, Moreira CC, Rahal P. Saint Louis encephalitis virus, Brazil. Emerg Infect Dis. 2007;13(1):176–178. doi: 10.3201/eid1301.060905 17370543

9. Mondini A, Bronzoni RV, Cardeal IL, dos Santos TM, Lázaro E, Nunes SH, et al. Simultaneous infection by DENV-3 and SLEV in Brazil. J Clin Virol. 2007;40(1):84–86. doi: 10.1016/j.jcv.2007.06.007 17658293

10. Estofolete CF, Terzian AC, Parreira R, Esteves A, Hardman L, Greque GV, et al. Clinical and laboratory profile of Zika virus infection in dengue suspected patients: A case series. J Clin Virol. 2016;81:25–30. doi: 10.1016/j.jcv.2016.05.012 27289428

11. Brasil. Boletim Epidemiológico. Monitoramento dos casos de dengue, febre de chikungunya e febre pelo vírus Zika até a Semana Epidemiológica 52, 2016. Brasilia: Ministério da Saúde; 2016.

12. SMS. Boletim Dengue 30/12/2015. Secretaria Municipal de Saúde de São José do Rio Preto; 2015.

13. SMS. Boletim Epidemiológico. Dengue segundo mês do inicio de sintomas, classificação final e óbitos residentes em São José do Rio Preto. Secretaria Municipal de Saúde de São José do Rio Preto; 2016.

14. Ferreira GL. Global dengue epidemiology trends. Rev Inst Med Trop Sao Paulo. 2012;54 Suppl 18:S5–6.

15. WHO. Dengue: guidelines for diagnosis, treatment, prevention and control—New edition. In. Geneva: World Health Organization (WHO) and the Special Programme for Research and Training in Tropical Diseases (TDR); 2009:160.

16. Srikiatkhachorn A, Rothman AL, Gibbons RV, Sittisombut N, Malasit P, Ennis FA, et al. Dengue—how best to classify it. Clin Infect Dis. 2011;53(6):563–567. doi: 10.1093/cid/cir451 21832264

17. Thein TL, Leo YS, Fisher DA, Low JG, Oh HML, Gan VC, et al. Risk factors for fatality among confirmed adult dengue inpatients in Singapore: a matched case-control study. PLoS One. 2013;8(11):e81060. doi: 10.1371/journal.pone.0081060 24278377

18. Nasim A, Anis S, Baqi S, Akhtar SF, Baig-Ansari N. Clinical presentation and outcome of dengue viral infection in live-related renal transplant recipients in Karachi, Pakistan. Transpl Infect Dis. 2013;15(5):516–525. doi: 10.1111/tid.12114 23890225

19. Weikert BC, Blumberg EA. Viral infection after renal transplantation: surveillance and management. Clin J Am Soc Nephrol. 2008;3 Suppl 2:S76–86.

20. Mallat S, Moukarzel M, Atallah D, Abou Arkoub R, Mourani C. Cytomegalovirus infection post kidney transplant: What Should We Know Now? J Med Liban. 2015;63(3):164–169. 26591198

21. Renaud CJ, Manjit K, Pary S. Dengue has a benign presentation in renal transplant patients: a case series. Nephrology (Carlton). 2007;12(3):305–307.

22. Brasil. Dengue: aspectos epidemiológicos, diagnósticos e tratamento. Brasilia: Ministerio da Saude; 2002.

23. Lanciotti RS, Kosoy OL, Laven JJ, Panella AJ, Velez JO, Lambert AJ, et al. Chikungunya virus in US travelers returning from India, 2006. Emerg Infect Dis. 2007;13(5):764–767. doi: 10.3201/eid1305.070015 17553261

24. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14(8):1232–1239. doi: 10.3201/eid1408.080287 18680646

25. de Morais Bronzoni RV, Baleotti FG, Ribeiro Nogueira RM, Nunes M, Moraes Figueiredo LT. Duplex reverse transcription-PCR followed by nested PCR assays for detection and identification of Brazilian alphaviruses and flaviviruses. J Clin Microbiol. 2005;43(2):696–702. doi: 10.1128/JCM.43.2.696-702.2005 15695666

26. Tan FL, Loh DL, Prabhakaran K, Tambyah PA, Yap HK. Dengue haemorrhagic fever after living donor renal transplantation. Nephrol Dial Transplant. 2005;20(2):447–448. doi: 10.1093/ndt/gfh601 15673696

27. Terzian AC, Mondini A, Bronzoni RV, Drumond BP, Ferro BP, Cabrera EM, et al. Detection of Saint Louis encephalitis virus in dengue-suspected cases during a dengue 3 outbreak. Vector Borne Zoonotic Dis. 2011;11(3):291–300. doi: 10.1089/vbz.2009.0200 20645866

28. Brasil. Dengue: diagnóstico e manejo clinico: adulto e criança. Ministério da Saúde. Secretaria de Vigilancia em Saúde. Diretoria Técnica de Gestão; 2013:80p.

29. Brasil. Dengue: diagnóstico e manejo clínico: adulto e criança [recurso eletrônico]. Brasília: Ministério da Saúde; 2016:58p.

30. Machado CM, Martins TC, Colturato I, Leite MS, Simione AJ, Souza MP, et al. Epidemiology of neglected tropical diseases in transplant recipients. Review of the literature and experience of a Brazilian HSCT center. Rev Inst Med Trop Sao Paulo. 2009;51(6):309–324. doi: 10.1590/s0036-46652009000600002 20209266

31. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998;11(3):480–496. 9665979

32. Kyle JL, Harris E. Global spread and persistence of dengue. Annu Rev Microbiol. 2008;62:71–92. doi: 10.1146/annurev.micro.62.081307.163005 18429680

33. Brasil. Casos de Dengue. Brasil, grandes regiões e Unidades Federadas. 1990 a 2016. In. Brasilia: Ministerio da Saude.; 2017.

34. Brasil. Dengue: Dados estatísticos. Secretaria Estadual de Saude de São Paulo. Centro de Vigilância Epidemiológica Prof. Alexandre Vranjac. Published 2017. Updated jun, 5 2017. Accessed Jun 25, 2017, 2017.

35. Stramer SL, Linnen JM, Carrick JM, Foster GA, Krysztof DE, Zou S, et al. Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico. Transfusion. 2012;52(8):1657–1666. doi: 10.1111/j.1537-2995.2012.03566.x 22339201

36. Weerakkody RM, Patrick JA, Sheriff MH. Dengue fever in renal transplant patients: a systematic review of literature. BMC Nephrol. 2017;18(1):15. doi: 10.1186/s12882-016-0428-y 28086881

37. Fernandes PF, Siqueira RA, Girão ES, Siqueira RA, Mota MU, Marques LC, et al. Dengue in renal transplant recipients: Clinical course and impact on renal function. World J Transplant. 2017;7(1):57–63. doi: 10.5500/wjt.v7.i1.57 28280696

38. Subbiah A, Bagchi S, Bhowmik D, Mahajan S, Yadav RK, Chhabra Y, et al. Dengue fever in renal allograft recipients: Clinical course and outcome. Transpl Infect Dis. 2018;20(3):e12875. doi: 10.1111/tid.12875 29512853

39. Azevedo LS, Carvalho DB, Matuck T, Alvarenga MF, Morgado L, Magalhães I, et al. Dengue in renal transplant patients: a retrospective analysis. Transplantation. 2007;84(6):792–794. doi: 10.1097/01.tp.0000280547.91617.25 17893614

40. Prasad N, Bhadauria D, Sharma RK, Gupta A, Kaul A, Srivastava A. Dengue virus infection in renal allograft recipients: a case series during 2010 outbreak. Transpl Infect Dis. 2012;14(2):163–168. doi: 10.1111/j.1399-3062.2011.00699.x 22212524

41. Simmons CP, Farrar JJ, Nguyen v V, Wills B. Dengue. N Engl J Med. 2012;366(15):1423–1432. doi: 10.1056/NEJMra1110265 22494122

42. Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol. 1992;30(3):545–551. 1372617


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