Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice

Autoři: Sorinel A. Oprisan aff001;  Xandre Clementsmith aff002;  Tamas Tompa aff003;  Antonieta Lavin aff003
Působiště autorů: Department of Physics and Astronomy, College of Charleston, Charleston, SC, United States of America aff001;  Department of Computer Science, College of Charleston, Charleston, SC, United States of America aff002;  Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States of America aff003;  Faculty of Healthcare, Department of Preventive Medicine, University of Miskolc, Miskolc, Hungary aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223469


The goal of this study was to investigate the effects of acute cocaine injection or dopamine (DA) receptor antagonists on the medial prefrontal cortex (mPFC) gamma oscillations and their relationship to short term neuroadaptation that may mediate addiction. For this purpose, optogenetically evoked local field potentials (LFPs) in response to a brief 10 ms laser light pulse were recorded from 17 mice. D1-like receptor antagonist SCH 23390 or D2-like receptor antagonist sulpiride, or both, were administered either before or after cocaine. A Euclidian distance-based dendrogram classifier separated the 100 trials for each animal in disjoint clusters. When baseline and DA receptor antagonists trials were combined in a single trial, a minimum of 20% overlap occurred in some dendrogram clusters, which suggests a possible common, invariant, dynamic mechanism shared by both baseline and DA receptor antagonists data. The delay-embedding method of neural activity reconstruction was performed using the correlation time and mutual information to determine the lag/correlation time of LFPs and false nearest neighbors to determine the embedding dimension. We found that DA receptor antagonists applied before cocaine cancels out the effect of cocaine and leaves the lag time distributions at baseline values. On the other hand, cocaine applied after DA receptor antagonists shifts the lag time distributions to longer durations, i.e. increase the correlation time of LFPs. Fourier analysis showed that a reasonable accurate decomposition of the LFP data can be obtained with a relatively small (less than ten) Fourier coefficients.

Klíčová slova:

Cocaine – Lasers – Neural networks – Prefrontal cortex – Pyramidal cells – Fourier analysis – Interneurons – Optogenetics


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