Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)


Autoři: Nora Denk aff001;  Peter Maloca aff002;  Guido Steiner aff001;  Christian Freichel aff001;  Simon Bassett aff001;  Tobias K. Schnitzer aff001;  Pascal W. Hasler aff002
Působiště autorů: Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland aff001;  OCTlab Research Laboratory, Department of Ophthalmology, University of Basel, Basel, Switzerland aff002;  Moorfields Eye Hospital, London, United Kingdom aff003;  Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222850

Souhrn

The purpose of this study was to measure central macular thickness in an unprecedented number of cynomolgus monkeys. Macular thickness was measured with Heidelberg spectral-domain OCT in 320 eyes of healthy and treatment-naïve cynomolgus monkeys (80 males and 80 females). The macula was successfully measured in all 320 eyes. Macular thickness was not significantly different between the sexes. The mean central macular thickness was 244 μm (+/- 21 μm). Macular thicknesses in the quadrants were 327 +/-17 μm (temporal inner), 339 +/- 17 μm (inferior inner), 341 +/- 14 μm (superior inner), 341 +/-18 μm (nasal inner), and 299 +/- 20 μm (temporal outer), 320 +/- 16 μm (superior outer), 332 +/-23 μm (inferior outer), and 337 +/-18 μm (nasal outer). Highly significant differences between the nasal and temporal quadrants were detected. This study successfully demonstrated the feasibility of retinal thickness measurements in healthy cynomolgus monkeys. The present findings indicate that the macula is thicker in cynomolgus monkeys than in humans and provide important normative data for future studies.

Klíčová slova:

Eyes – Fovea centralis – In vivo imaging – Monkeys – Primates – Retina – Tomography – Toxicology


Zdroje

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PLOS One


2019 Číslo 10

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