Contrast-enhanced spectral mammography with a compact synchrotron source

Autoři: Lisa Heck aff001;  Martin Dierolf aff001;  Christoph Jud aff001;  Elena Eggl aff001;  Thorsten Sellerer aff001;  Korbinian Mechlem aff001;  Benedikt Günther aff001;  Klaus Achterhold aff001;  Bernhard Gleich aff001;  Stephan Metz aff003;  Daniela Pfeiffer aff003;  Kevin Kröninger aff002;  Julia Herzen aff001
Působiště autorů: Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748 Garching, Germany aff001;  Chair for Experimental Physics IV, TU Dortmund University, 44221 Dortmund, Germany aff002;  Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany aff003
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article


For early breast cancer detection, mammography is nowadays the commonly used standard imaging approach, offering a valuable clinical tool for visualization of suspicious findings like microcalcifications and tumors within the breast. However, due to the superposition of anatomical structures, the sensitivity of mammography screening is limited. Within the last couple of years, the implementation of contrast-enhanced spectral mammography (CESM) based on K-edge subtraction (KES) imaging helped to improve the identification and classification of uncertain findings. In this study, we introduce another approach for CESM based on a two-material decomposition, with which we expect fundamental improvements compared to the clinical procedure. We demonstrate the potential of our proposed method using the quasi-monochromatic radiation of a compact synchrotron source—the Munich Compact Light Source (MuCLS)—and a modified mammographic accreditation phantom. For direct comparison with the clinical CESM approach, we also performed a standard dual-energy KES at the MuCLS, which outperformed the clinical CESM images in terms of contrast-to-noise ratio (CNR) and spatial resolution. However, the dual-energy-based two-material decomposition approach achieved even higher CNR values. Our experimental results with quasi-monochromatic radiation show a significant improvement of the image quality at lower mean glandular dose (MGD) than the clinical CESM. At the same time, our study indicates the great potential for the material-decomposition instead of clinically used KES to improve the quantitative outcome of CESM.

Klíčová slova:

Clinical laboratories – Imaging techniques – Iodine – Photons – X-ray radiography – Mammography – Synchrotrons – Calcium imaging


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