Testing gene by community disadvantage moderation of sexual health outcomes among urban women

Autoři: Terrinieka W. Powell aff001;  Jill A. Rabinowitz aff002;  Michelle R. Kaufman aff003;  Adam J. Milam aff002;  Kelly Benke aff002;  Danielle Y. Sisto aff002;  George Uhl aff004;  Brion S. Maher aff002;  Nicholas S. Ialongo aff002
Působiště autorů: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America aff001;  Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America aff002;  Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America aff003;  New Mexico VA HealthCare System, Las Vegas, NM, United States of America aff004
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223311


We examined whether the interplay between community disadvantage and a conduct disorder polygenic risk score (CD PRS) was associated with sexual health outcomes among urban women. Participants (N = 511; 75.5% African American) were originally recruited to participate in a school-based intervention and were followed into adulthood. Community disadvantage was calculated using census data when participants were in first grade. At age 20, blood or saliva samples were collected and participants reported on their condom use, sexual partners, and sexually transmitted infections. A CD PRS was created based on a genome-wide association study conducted by Dick et al. [2010]. Higher levels of community disadvantage was associated with greater sexually transmitted infections among women with a higher CD PRS. Implications of the study findings are discussed.

Klíčová slova:

African American people – Genome-wide association studies – Human genetics – Human sexual behavior – Sexually transmitted diseases – Socioeconomic aspects of health – Women's health – Genetic load


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Článek vyšel v časopise


2019 Číslo 10