Brain metastasis-related microRNAs in patients with advanced breast cancer


Autoři: Jun Sato aff001;  Akihiko Shimomura aff001;  Junpei Kawauchi aff002;  Juntaro Matsuzaki aff003;  Yusuke Yamamoto aff003;  Satoko Takizawa aff002;  Hiromi Sakamoto aff004;  Makoto Ohno aff005;  Yoshitaka Narita aff005;  Takahiro Ochiya aff003;  Kenji Tamura aff001
Působiště autorů: Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan aff001;  Toray Industries, Inc., Kanagawa, Japan aff002;  Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan aff003;  Department of Biobank and Tissue Resources, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Tokyo, Japan aff004;  Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan aff005;  Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan aff006
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: 10.1371/journal.pone.0221538

Souhrn

Brain metastasis is a major distant metastasis occurring in patients with advanced breast cancer, and is associated with poor prognosis. MicroRNAs (miRNAs) have a strong influence on various oncological functions and have been reported as potential biomarkers for detecting distant metastasis. Specific biomarkers and unique miRNAs for brain metastasis have yet to be reported. The aim of this study was to identify novel miRNAs in serum, to assist in the diagnosis of brain metastasis in patients with advanced breast cancer. We retrospectively analyzed the medical records of patients with breast cancer and collected clinical data. In addition, we evaluated serum miRNA profiles in patients with breast cancer, with and without brain metastasis, using high-sensitivity microarrays. All patients underwent computed tomography or magnetic resonance imaging brain imaging tests. A total of 51 serum samples from patients with breast cancer and brain metastasis, stored in the National Cancer Center Biobank, were used, and 28 serum samples were obtained from controls without brain metastasis. Two miRNAs, miR-4428 and miR-4480, could significantly distinguish patients with brain metastasis, with area under the receiver operating characteristic curve (AUC) values of 0.779 and 0.781, respectively, while a combination of miR-4428 and progesterone receptor had an AUC value of 0.884. No significant correlations were identified between the expression levels of these two miRNAs in serum and clinical data. We conclude that serum miR-4428 and miR-4480 may be useful as biomarkers for predicting brain metastasis in patients with breast cancer.

Klíčová slova:

Biomarkers – Breast cancer – Cancer detection and diagnosis – Cancer treatment – Metastasis – Microarrays – MicroRNAs – Brain metastasis


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2019 Číslo 10

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