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ReklamaThe impact of shared knowledge on speakers’ prosody
Authors: Amandine Michelas aff001; Cécile Cau aff001; Maud Champagne-Lavau aff001
Authors place of work: Aix Marseille Univ, CNRS, LPL, Aix-en-Provence, France aff001
Published in the journal: PLoS ONE 14(10)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0223640Summary
How does the knowledge shared by interlocutors during interaction modify the way speakers speak? Specifically, how does prosody change when speakers know that their addressees do not share the same knowledge as them? We studied these effects in an interactive paradigm in which French speakers gave instructions to addressees about where to place a cross between different objects (e.g., You put the cross between the red mouse and the red house). We manipulated (i) whether the two interlocutors shared or did not necessarily share the same objects and (ii) the informational status of referents. We were interested in two types of prosodic variations: global prosodic variations that affect entire utterances (i.e., pitch range and speech rate variations) and more local prosodic variations that encode informational status of referents (i.e., prosodic phrasing for French). We found that participants spoke more slowly and with larger pitch excursions in the not-shared knowledge condition than in the shared knowledge condition while they did not prosodically encode the informational status of referents regardless of the knowledge condition. Results demonstrated that speakers kept track of what the addressee knew, and that they adapted their global prosody to their interlocutors. This made the task too cognitively demanding to allow the prosodic encoding of the informational status of referents. Our findings are in line with the idea that complex reasoning usually implicated in constructing a model of the addressee co-exists with speaker-internal constraints such as cognitive load to affect speaker’s prosody during interaction.
Keywords:
Cognitive psychology – Vision – Acoustics – Computers – Syllables – Speech – Vowels – Finches
Introduction
The way speakers share or do not share knowledge with their interlocutors during interaction has consequences for words they produce but also for the prosody associated with the words. The term prosody refers to variations of suprasegmental features of speech including pitch, duration and intensity. When these three acoustic parameters vary, it induces different kinds of prosodic variations. First, it creates local prosodic variations that affect words or small groups of words through prosodic prominence attribution (i.e., through the degree to which these words perceptually stand out from surrounding words). Second, it provides more global prosodic variation that affects entire utterances such as speech rate and pitch range variations. The present article deals with the possible impact of shared knowledge manipulation between interlocutors on one or both of these two kinds of prosodic variations in French.
The first evidence of the impact of shared knowledge on speakers’ prosody comes from the fact that speakers encode the already-mentioned vs. contrastive status of words through prosodic prominence by consulting information that is mutually shared with their interlocutors ([1]). For instance, in most Germanic languages such as English or Dutch, speakers select deaccenting forms for already-mentioned words and prosodic prominent forms for contrastive words ([1–5]). In contrast to Germanic languages, it appears that the correspondence between deaccenting vs. prosodic prominence and information status is less systematic in Romance languages. For instance, it appears that Catalan and Spanish make less use of prosodic prominence to mark information status but also rely on syntactic strategies affecting word order (see [6], for a discussion of the distinction between the prosodic marking of information status in Germanic and in Romance languages). Similar to what happens in Catalan and Spanish, at least two strategies are allowed in French to encode the new vs. given status of words: syntactic strategies such as dislocations (see [7]) or just prosodic marking. In French, due to the absence of lexical stress, the prosodic encoding of focus is different from that one of many other Romance languages, and mainly relies on prosodic phrasing (i.e., the grouping of words into prosodic units of different sizes). Specifically, a number of studies have reported a tendency for contrastive words to be parsed in a separate prosodic unit from the rest of the utterance ([7–11]). For instance, using a paradigm in which participants had to correct sentences produced by a fictitious interlocutor (a prompt), Dohen & Loevenbruck [8] showed that participants produced utterances with the verb phrase and the object noun phrase grouped together in the same prosodic constituent (the Accentual Phrase or AP) in contexts in which no element of the utterance contrasted with a previously-mentioned discourse element (e.g., [Les loups]AP [suivaient Marie-Lou]AP ‘The wolves were following Marie-Lou’). However, they produced the element that contrasted with a previously mispronounced element in a separate AP when they knew that the prompt conveyed false-belief about this element (e.g., [Les loups]AP [suivaient]AP [Marie-Lou]AP when ‘Marie-Lou’ was mispronounced). More recently, in an interactive paradigm in which a director had to indicate noun-adjective pairs of items to an addressee, Michelas, Faget, Portes, Lienhart, Boyer, Lançon, et al. ([11]), showed that French participants parsed the target noun in the same AP as the following adjective when it was identical to the noun in the preceding fragment (e.g., bonbons marron ‘brown candies’ followed by [bonbons violets]AP ‘purple candies’) while they parsed it in a separate AP from the following adjective when it contrasted with it to warn their interlocutor that this noun constituted a contrastive entity (e.g., bougies violettes ‘purple candles’ followed by [BONBONS]AP[violets]AP ‘purple candies’). It is not clear whether this phenomenon resulted from a speakers’ willingness to help their addressee (as predicted by ‘the audience design hypothesis’; see [12]) or whether it is mediated by production-internal constraints on the speakers’ part that favor speech that is easy to produce ([13–17]). Nevertheless, it appears that when speakers share a set of alternatives with their partner, they prosodically encode the new vs. given status of word.
Moreover, it is possible that the way in which interlocutors shared knowledge during the interaction affects not only the prominent words but also all other regions of speakers’ utterance. This idea is related to the fact that when speakers are aware of a speech perception difficulty on the part of addressees, they modify their global prosody (see [12] for a review). For instance, a lot of studies focusing on ‘clear speech’ (a distinct listener-oriented speaking style that is more intelligible than conversational speech) converge on the idea that speakers decrease their speech rate and increase their wider dynamic pitch range in order to accommodate addressees in contexts in which their listener experience background noise, hearing impairments or a different native language, ([18–26]). Following this idea, it is reasonable to hypothesize that when speakers are aware they do not share the same knowledge as their interlocutors, they produce clear speech thus modifying their global prosody to prevent their listeners from comprehension difficulties.
In the present study, we collected speech samples in a controlled but interactive paradigm that enabled us to measure prosodic variations on speech fragments that refer either to objects shared by the two interlocutors (shared knowledge condition) or that refer to objects that might differ between the two interlocutors (not-shared knowledge condition). In the paradigm we built, participants played an interactive game. They were seated in a quiet room with a confederate, facing each other, both with a computer screen. The participants had to give instructions to the confederate about where to place a cross between the different objects displayed on the screen (e.g., Tu mets la croix entre la souris bordeau et la maison bordeau; ‘You put the cross between the red mouse and the red house’). The participants knew that when objects appeared in white boxes, the confederate shared exactly the same objects as them on her screen while this was not necessarily the case when objects appeared in black boxes. In this case, participants knew that objects displayed on black boxes could differ either in their type (e.g., mouse vs. car) or in their color (e.g., red vs. purple) on the confederate’s screen. We had two goals. Our first goal was to test whether the fact that the speakers knew their addressee shared or did not necessarily share the same set of objects/colors as them, affected the global prosodic variations they produce. Following the idea that speakers adapt their global prosody to the difficulties encountered by their addressee during spoken interaction, we hypothesized that, in the absence of shared knowledge between participants, speakers would modify their global prosodic features such as speech rate and pitch range to facilitate addressees’ comprehension as it is the case in clear speech. Specifically, we predicted that speakers would speak more slowly and with larger pitch incursions in a condition in which they knew their interlocutor did not necessarily share the same knowledge (not-shared knowledge condition) compared to a condition in which they knew s/he shared it (shared-knowledge condition). Our second goal was to test whether shared knowledge between interlocutors affected prosodic variations that encoded informational status of referents. To do so, we manipulated the contrastive status of target fragments that always appeared in second position within pairs produced by the speaker (e.g., maison bordeau ‘red house’ in Tu mets la croix entre la souris bordeau et la maison bordeau; ‘You put the cross between the red mouse and the red house’). Within these target fragments, (1) the target noun was identical to the noun of the 1st fragment while the target adjective contrasted to the one in the 1st fragment (e.g., maison violette vs. maison BORDEAU) contrastive adjective, (2) the target noun in the 2nd fragment contrasted to the noun in the 1st fragment while the adjective was identical (e.g., souris bordeau vs. MAISON bordeau; contrastive noun) (3) both the target noun and the target adjective contrasted to their counterparts in the 1st fragment (e.g., souris violette vs. MAISON BORDEAU; contrastive fragment). Following Michelas, Faget, Portes, Lienhart, Boyer, Lançon, et al. ([11]) and others, we hypothesized that the presence of shared knowledge between participants would affect the prosodic encoding of informational status of referents and thus the prosodic phrasing produced by French participants. Specifically, we predicted that speakers would isolate contrastive nouns in separate APs when they knew their interlocutor shared exactly the same set of alternatives/objects as them (shared knowledge condition) but not when they knew their interlocutor did not necessarily share it (not-shared knowledge condition). Thus, we expected participants to produce more 2 AP phrasing in the contrastive noun condition (souris bordeau vs. MAISON bordeau, ‘red mouse vs. red house’) compared to the contrastive adjective condition (maison violette vs. maison BORDEAU ‘purple house vs. red house’) in shared knowledge circumstances but not in not-shared knowledge circumstances. In this last case, it would not be relevant for speakers to highlight one particular alternative to their addressee since they knew their interlocutor did not necessarily share the same set of alternatives as them. Finally, we tested an additional condition in which both the target noun and the following adjective were contrastive (souris violette vs. MAISON BORDEAU ‘purple mouse vs. red house’) to see whether our chance to obtain a 2 AP phrasing is increased when the entire fragment (and not only the noun) is contrastive. This hypothesis is based on Michelas, Faget, Portes, Lienhart, Boyer, Lançon, et al. ([11])’s study who obtained more 2 APs phrasing (72% of cases) than 1 AP phrasing (28% of cases) on filler items showing this kind of “double contrast”. If this double contrast actually favors the parsing of the noun in a separate AP from the following adjective as it was the case in Michelas, Faget, Portes, Lienhart, Boyer, Lançon, et al. ([11])’s study, speakers would produce more 2 APs phrasing in our contrastive fragment condition compared to our contrastive noun condition in shared knowledge circumstances.
Method
Participants
Twenty-two participants (16 women) between 18 and 47 years old (mean age = 21.4, SD = 5.9; mean education: 13.8 years, SD = 0.8) participated in the experiment. All participants gave written informed consent. All reported having no neurological, psychiatric, visual or hearing impairment. They were all native speakers of French, the language of the experiment. The study was approved by the university’s ethics review board (Comité d’évaluation éthique d’Aix-Marseille université) and conducted according to the principles expressed in the Declaration of Helsinki. The experiment was classified as purely behavioral, and the testing involved no discomfort or distress to the participants.
Materials
An interactive task involving cooperation between a director (the participant) and an addressee (a confederate) was developed for the present study. During this task, the director had to give instructions to the addressee about where to place a cross between different objects on a grid by naming the type and the color of two critical objects (e.g., Tu mets la croix entre la souris bordeau et la maison bordeau; ‘You put the cross between the red mouse and the red house’). Each grid was composed of 16 objects corresponding to the combination of 4 types of objects and 4 colors. For instance Fig 1 illustrates the director’s and addressee’s grid built around the 4 following colors: bordeau ‘red’ (critical color), violet ‘purple’ (critical color), vert ‘green’ (filler color), bleu ‘blue’ (filler color) and the 4 types of object: souris ‘mouse’ (critical object), maison ‘house’ (critical object), pomme ‘apple’ (filler object), voiture ‘car’ (filler object). A total of 56 different types of object were used to build the 84 grids of the experiment. These grids were created from 14 target fragments (2 knowledge conditions x 3 informational status conditions x 14 target noun-adjective fragments). The objects and the colors of the critical pair were chosen so that we controlled for the words produced by the participants (e.g., the number of syllables, the syllable structure and the phonemic characteristics of words).
Fig. 1. In half of the grids, the cross has to be placed horizontally (as it is the case in Fig 1) whereas in the other half, it has to be placed vertically. The location of the cross was stable for the same target fragment (e.g. maison bordeau ‘red house’) that appeared six times in the six different conditions (see details of the 6 experimental conditions below) but was never the same across the 14 target fragments so that participants cannot anticipate the location of the cross. In the immediate proximity of the two target items (i.e., below the two target items when the cross has to be placed horizontally and on the left of the two target items when the cross has to be placed vertically), a competitor object and a filler object were always visible. The competitor object consisted of a different object of the same color for the contrastive noun condition (see the list of the experimental conditions below and in Table 1), the same object but in a different color for the contrastive adjective condition and a different object with a different color for the contrastive fragment condition. The filler object was always a different object than the objects used for the target pair and the competitor and had always a different color. The other objects on the grid were randomly arranged. Each pair of target items gave rise to six different grids (one for each experimental conditions). The arrangement of objects was the same for each sextuplet of grids except for the white/black boxes manipulations as explained in the following paragraph.
Tab. 1. Noun-adjective pairs, corresponding to the maison bordeau ‘red house’ target fragment, elicited by the task and thus produced by directors for each of the 6 experimental conditions. We developed two experimental manipulations. First, to control for the presence vs. absence of shared knowledge between participants, we manipulated the speaker’s knowledge about whether his/her addressee shared or did not necessarily share the same objects as him/her. To do so, in the not-shared knowledge condition, target items appeared in black boxes and participants knew that they could have different objects or different colors for objects in those boxes (see Fig 1 bottom panel) while in the shared knowledge condition, items appeared in white boxes meaning for the participants that their interlocutor shared exactly the same objects as him/her (see Fig 1 top panel). The black boxes were always four in number and their distribution was conditioned by the type of contrast for the current pair of objects. For instance, for the ‘red mouse vs. red house’ pair (contrastive noun), the four black boxes affected the four red objects. In the same manner, for the ‘purple house vs. red house’ pair (contrastive adjective), the four black boxes affected the four houses. For the contrastive fragment pair, the four black boxes affected the four objects of the same color as the target item for half of the target pairs (e.g., the four red objects for the ‘purple mouse vs. red house’ pair) or the four objects of the same type as the target item for the other half of the target pairs (e.g., the four mills for the ‘orange sun vs. brown mill’ pair). To obtain the addressee’s grid in the not-shared knowledge condition, the second object of pairs of objects was always replaced by one of the two other possible alternatives on the grid. For instance, in Fig 1, the red house in the director’s grid was replaced by the red car in the addressee’s grid. This manipulation allowed us to create a situation in which participants always shared the same set of objects for a given grid but knew that, sometimes, critical objects or colors might differ at a given location on the addressee’s screen and sometimes they might actually be the same even though they appeared in black boxes. The location of black boxes was stable for the same target fragment that appeared six times in the six different conditions but was different across the 14 target fragments so that participants cannot anticipate their location. The complete instructions given to participants are shown in S1 Appendix.
Second, in order to control for the informational status of referents, we manipulated whether the noun or the adjective in the 2nd fragment was the same or contrasted with the noun or the adjective in the 1st fragment. We obtained three types of informational status: (1) the noun in the 2nd fragment was kept constant while the adjective in the 2nd fragment contrasted to the adjective in the 1st fragment (e.g., maison violette vs. maison BORDEAU) contrastive adjective (2) the noun in the 2nd fragment contrasted to the noun in the 1st fragment while the adjective was kept constant (e.g., souris bordeau vs. MAISON bordeau; contrastive noun) (3) both the noun in the 2nd fragment contrasted to the noun in the 1st fragment and the adjective in the 2nd fragment contrasted to the adjective in the 1st fragment (e.g., souris violette vs. MAISON BORDEAU; contrastive fragment).
The combination of the two experimental factors (type of knowledge and informational status of target fragment) led to 6 experimental conditions. The 6 noun-adjective pairs corresponding to the 6 experimental conditions for the maison bordeau target fragment were given as example in Table 1. The target fragment was always the second fragment of the pair (e.g., red house in the ‘red mouse vs. red house’ pair). Each participant saw the 84 screens (2 knowledge conditions x 3 informational status conditions x 14 target noun-adjective fragments) that appeared simultaneously on his/her computer’s screen and on the computer’s screen of his/her addressee. The order of presentation of screen view was fixed across participants but was semi-randomized within participants so that the same target item did not appear more than twice in succession and the same experimental condition was not repeated more than twice in a row.
Procedure
The director and the addressee were seated, facing each other, both with a computer screen. They could not see each other’s computer screen. The director was asked to give instructions to the addressee about where to place the cross by indicating to the addressee the type and the color of objects (e.g., Tu mets la croix entre la souris bordeau et la maison bordeau; ‘You put the cross between the red mouse and the red house’). The addressee was always the same confederate (i.e., a native French female speaker). She was introduced to the participant as the experimenter but was naïve about the scientific aims of the experiment. However, since the addressee performed the task 22 times in the exact same order, she received instructions about the feedbacks she was allowed to produce. These instructions were intended to homogenize the feedbacks she produced from one participant to another. When she interacted with the participant, she was explicitly asked to give him/her continual feedback of two types. First, in cases in which she identified immediately and without effort where to put the cross, she was asked to signal understanding with feedbacks such as d’accord ‘okay’, ok ‘okay’, c’est bon ‘I’m good’. Second, in cases in which she had difficulties to identify where to place the cross (typically in case of black boxes), she was instructed to tell the participant why she is in difficulties (e.g., Alors je n’ai pas de souris bordeau et de maison bordeau à côté ‘Well, I don’t have any red house next to a red mouse’) and to ask them for clarifications leading to several exchanges between the two interactional partners. Clarification questions could be of three types: (i) vague clarification question (e.g., Je n’ai pas bien compris ‘I don’t understand very well’, Tu peux répéter? ‘Can you repeat?’, Je suis un perdue, est-ce que tu peux me répéter ce que tu vois ? ‘I’m lost, can you tell me what you see ? ’), (ii) precise clarification question (e.g., Où est-ce que je dois mettre la croix par rapport à la souris bordeau ? ‘Where should I put the cross in relation to the red mouse?’, Dans quelle colonne se situe la croix? ‘In which column is the cross located ? ’) (iii) inference clarification question (e.g., Est-ce que je dois mettre la croix en dessous du bureau bordeau? ‘Do I have to put the cross below the red desk ? Est-ce que la croix est à gauche du crayon marron ? ‘Is the cross to the left of the brown pencil ?’, Est-ce que la croix est sur la même ligne que le crayon violet ? ‘Is the cross on the same line as the purple pencil?’). After identifying the location of the cross, the confederate had to show the participant her understanding using feedback such as ‘okay’. We recorded both the director’s and addressee’s productions, but we only analyzed the director’s productions. The types of feedback did not give rise to any coding. Moreover, regardless of the type of exchange that took place between the director and the addressee, the segment of speech we analyzed was always extracted from the initial production of the speaker. This segment was elicited before any confederate’s reaction. For instance, we did not analyze cases in which the speaker repeated target fragments after a clarification question asked by the addressee. An extract from the dialogue obtained between one participant and the confederate is given as example in S2 Appendix. This extract corresponds to the screen views shown in Fig 1.
Each screen view appeared simultaneously on the director and the addressee computer’s screen. Once the addressee has moved the cross with the computer mouse on his/her screen, both participants were asked to simultaneously click on the space bar to make the next screen view appeared. The director and the addressee were recorded in a quiet room using a Zoom H4N Handy Recorder and a Headset Cardioid Condenser Microphone (AKG C520). We analyzed directors’ speech only.
The experimental phase began with 6 practice screen views followed by 84 target screen views. The 6 practice screen views were built from 8 new objects and 8 new colors that did not appear in the 84 target screen views.
To ensure that directors could identify and use a consistent label for each target object and color, before the experimental phase, participants performed a familiarization phase during which they had to report aloud what they saw in 64 pictures. These 64 pictures were composed of all the possible objects participants met in the experimental phase (56 different objects) in one of the 4 possible colors used for the experimental phase plus the 8 objects of the 6 practice items also randomly assigned to one of the possible colors. When participants mispronounced or use a different labels to name the target objects and/or the target colors, they were corrected by the experimenter, they were asked to repeat the correct labels and to remember these labels, as they would see the same object/color in the next phase of the game.
Measures and annotations
One item that gave rise to object label errors in more than 75% was removed from the analyses. Analyses were performed on pairs containing neither disfluencies/hesitations nor object label errors for a total of 1461 pairs, thus removing 255 pairs (14.9%) out of the 1716 pairs. In these pairs, we analyzed both global prosodic variations and prosodic phrasing as a marker of informational status of referents.
We first analyzed whether speakers modulate their global prosody depending on whether they shared knowledge or not with their interlocutor. To do so, we measured speech rate and pitch range. These are the two main global prosodic acoustic-phonetic features that characterize clear speech production (see [12]). We calculated average speech rate in syllables/second for the entire pairs of noun-adjective fragments (e.g., ‘the red mouse and the red house’). We first calculated the total duration of the entire pair of noun-adjective fragments (see ‘Pair’ in Fig 2) according to the following procedure. Each entire pair of noun-adjective fragments (e.g., la souris bordeau et la maison bordeau ‘the red mouse and the red house)’ had a base syllable count of 11 syllables. The first author listened to each utterance and adjusted the base count for the very rare cases in which the speaker did not produce the schwa at the end of the article le ‘the’ (e.g. [lə. mu. tɔ̃. ma. ʁɔ̃. e. lbe. ʀɛ. ma. ʁɔ̃] instead of [lə. mu. tɔ̃. ma. ʁɔ̃. e. lə. be. ʀɛ. ma. ʁɔ̃] le mouton marron et le beret marron ‘brown sheep and brown beret’). This syllable count was divided by the utterance duration to obtain a rate measurement for each entire pairs of noun-adjective fragments. We then measured pitch range variations. Two main types of pitch range variations have been reported in the literature: the first is called ‘pitch level’ ([28]) or ‘register’ ([5]) and corresponds to the raising or lowering of the melodic movements in the fundamental frequency (F0) space. For instance, when we speak with higher pitch level than usual to imitate the voice of a child, both F0 minima and maxima are produced higher so that the entire F0 contour is produced higher in the F0 space. The other way in which pitch range is varied concerns the ‘pitch span’ ([28]) also referred to as the ‘excursion size’ ([29]). This measure refers to the distance between the highest and the lowest pitches point in the contour. When the pitch span is increased, F0 maxima are produced higher than usual while F0 minima stay the same. Since clear speech research has reported ‘a wider dynamic pitch range’ (e.g., a larger pitch span) when speakers are aware of perception difficulties from their listener, we measured pitch range variations as pitch span variations in our study. We defined pitch span as the difference between maximum and minimum F0 values for the entire pair of noun-adjective fragments. Maximum and minimum F0 values were automatically extracted using Praat scripts ([30]).
Fig. 2. Schema annotation for the pair une souris bordeau et une maison bordeau ‘the red house and the red house’. Second, in order to analyze whether the presence of shared knowledge between participants affected the prosodic encoding of informational status of referents, we examined whether speakers produced the noun in the 2nd fragment in the same AP as the following adjective (e.g., [maison bordeau]AP ‘red house’) or in a separate AP (e.g., [maison]AP [bordeau]AP). Pre-boundary lengthening and the presence of a typical F0 rise aligned with the last syllable of the AP are well known as the two main correlates of AP right boundaries in French ([31–33]). Specifically, the last full syllable of the AP has been shown to exhibit longer duration than unaccented syllables within an AP. In addition, APs in non-final position within the utterance are typically characterized by a rising F0 contour aligned with the last full syllable of the AP. For these reasons, we measured duration of the first and second syllables of target nouns (respectively S1 and S2 in Fig 2). We also extracted F0 values corresponding to the F0 minimum hertz value of the 1st syllable of target nouns and to the F0 maximum hertz value of the last syllable of target nouns. Based on these tagged features, we used two specific criteria to define the presence of an AP right boundary (see Michelas, Faget, Portes, Lienhart, Boyer, Lançon, et al. ([11) for the same procedure). First, following the pitch accent detection criterion used by [34] on French data, we considered that an AP right boundary was actually produced by the speaker after the target noun if the F0 maximum hertz value of the last syllable of the target noun was at least 10% higher than that of the F0 minimum hertz value of the 1st syllable of target nouns. Second, we also verified that the syllable was lengthened. To do so, we checked whether the duration of the last syllable of the target noun was at least 10% longer than that of the preceding syllable. This is in line with Michelas, Faget, Portes, Lienhart, Boyer, Lançon, et al. ([11) who found that healthy control speakers parsed contrastive referents in a separate AP using two specific criteria to define the presence of an AP boundary (a 10% threshold for pitch accent detection and a 10% threshold for syllable lengthening). [33] reports results from a corpus study that compared vowel duration in different prosodic positions (within words, in AP-final position, in ip-final position and in IP-final position) at different speech rates (i.e., normal and fast speech rates) and for different speakers (i.e., males and females). This study also demonstrated that AP-final vowels are more or less 10% longer than a vowel contained within an AP and is thus in accordance with the criterion used by [33].
All the performed annotations are summed up below and illustrated in Fig 2:
Pair: entire noun-adjective pair
det’: determinant of the 1st fragment
S1’: 1st syllable of the 1st fragment
S2’: 2nd syllable of the 1st fragment
S3’: 3rd syllable of the 1st fragment
S4’: 4th syllable of the 1st fragment
det: determinant of the 2nd fragment
S1: 1st syllable of the 2nd fragment
S2: 2nd syllable of the 2nd fragment
S3: 3rd syllable of the 2nd fragment
S4: 4th syllable of the 2nd fragment
Duration measures:
F0min_Pair: F0 minima for the entire pair of fragments
F0max_Pair: F0 maxima for the entire pair of fragments
L: low inflection point in the F0 curve near the beginning of the first syllable of the noun in the 2nd fragment
H: F0 maximum hertz value of the last syllable of the same target noun
F0 measures:
All the values corresponding to these labels were extracted thanks to Praat ([30]) scripts written by our own.
Results
Global prosodic variations
Mean of pitch span (in Hz) and mean of speech rate (in syl/s) are shown in Figs 3 and 4 respectively.
Fig. 3. Mean of pitch span depending on the type of knowledge and the informational status of the target fragment. Error bars show 95% confidence intervals. Fig. 4. Mean of speech rate depending on the type of knowledge and the informational status of the target fragment. Error bars show a 95% confidence interval. Two linear mixed-effects regression models were used on the log-transformed pitch span and speech rate values. Taking the log transformations ensures a normal distribution of the residuals ([35]). Both models included the informational status, the type of knowledge and the interaction between the two factors as fixed effects. Following [36], we used the maximal random effects structure that allowed the model to converge. Participants and items were thus included as random intercepts (random slopes by participant for the effect of informational status and type of knowledge were included only for the speech rate model since they did not allow the pitch span model to converge). Global effects were obtained using the afex::mixed function.
The pitch span model revealed a significant main effect of type of knowledge (X2 = 8.65 p < .01) due to a larger pitch span in the not-shared knowledge condition compared the shared-knowledge condition. The effect of informational status (X2 = 3.07, p >.20) and the informational status x type of knowledge interaction (X2 = 3.90, p = .14) were not significant. Since referents were repeated 6 times across our 6 experimental conditions and since repetition is a well-established contributor to acoustic attenuation, we reran the same model with repetition as a fixed factor. Repetition was coded R1-R6 and was not centered because it was not a numerical variable. This additional model showed that there was no significant effect of the repetition factor (X2 = 2.69, p >.20).
The speech rate model revealed a significant main effect of type of knowledge (X2 = 37.37, p < .0001) due to faster speech rate in the shared knowledge condition compared to the not-shared knowledge condition. The effect of informational status was not significant (X2 = 4.25, p = .12). The informational status x type of knowledge interaction was also significant (X2 = 7.60, p < .05). Multiple comparisons (Tukey test, p <. 05) obtained with the glht function from the multcomp package ([37]) with p-values adjusted by the single step method revealed that this significant interaction was due to faster speech rate in the contrastive noun condition compared to the contrastive fragment condition (z = 3.00, p < .05) and a tendency for faster speech rate in the contrastive noun condition compared to the contrastive adjective condition (z = 2.81, p = 0.056) in the shared knowledge condition. As for the pitch span model, we reran our statistical model with repetition as a fixed factor. In a similar way to what happened for the pitch span model, there was no significant effect of repetition on the log-transformed speech rate values (X2 = 4.66, p >.20).
Prosodic encoding of informational status
Proportion of items in the coded sample that included 2 APs depending on the type knowledge shared by participants and the informational status of target fragments shared is shown in Table 2.
Tab. 2. Proportion of items in the coded sample that included 2 APs phrasing (in %). As shown in Table 2, there was a large bias in favor of the 1 AP phrasing compared to the 2 AP phrasing regardless of the type of knowledge and of the informational status of target fragments. We used a mixed-effects regression model (lme4 package in R-studio statistics Version 0.99.903) with a logistic linking function to confirm the statistical relevance of this bias. The model included the AP phrasing as dependent variable (1 = 2 APs, 0 = 1AP), the informational status (contrastive adjective, contrastive noun, contrastive fragment), the type of knowledge (shared-knowledge, not-shared knowledge) and the interaction between the two factors as fixed effects. Following [36], we used the maximal random effects structure that allowed the model to converge. Participants and items were thus included as random intercepts only (random slopes by participants and by items were not included because they did not allow the model to converge). Neither the effect of the two factors (effect of informational status: X2 = 0.24, p > .20; effect of type of knowledge: X2 = 0.0004, p > .20), nor the informational status x type of knowledge interaction was significant (X2 = 2.00, p > .20). As with the global prosodic variations, we reran our statistical model with repetition as fixed factor. The additional model showed that there was no significant effect of repetition on the AP-phrasing produced by participant (X2 = 3.19, p >.20).
We also fitted two linear mixed effects models on the acoustic parameters we used (duration and F0 values associated with target syllables) to define the presence or the absence of an AP at the right edge of target noun. Durations of target syllables in milliseconds (S2’ in Fig 2 above) are illustrated in Fig 5 while logarithms of F0 maxima associated with target syllables (H in Fig 2 above) are illustrated in Fig 6.
Fig. 5. Boxplots of target syllable duration (in ms) depending on the informational status of target fragments and knowledge shared by participants. Fig. 6. Boxplots of logarithms of maximum F0 values associated with target syllables depending on the informational status of target fragments and knowledge shared by participants. The two models included log-transformed values as dependent variables to ensure a normal distribution of the residuals ([35]). The informational status of referents (contrastive adjective, contrastive noun, contrastive fragment), the type of knowledge (shared-knowledge, not-shared knowledge) and the interaction between the two factors were included as fixed effects. Following [36], we used the maximal random effects structure that allowed the model to converge. The duration values model also included random intercepts by participant and by item and random slopes by participant for the two fixed effects. For the F0 values model, participants and items were included as random intercepts only (random slopes by participants and by items were not included because they did not allow the model to converge).
For duration values, the effect of type of knowledge (X2 = 87.03, p < .0001) was significant due to longer values in the not-shared knowledge condition than in the shared knowledge condition. The effect of informational status was also significant (X2 = 20.49, p < .0001) due to longer values in the contrastive fragment condition compared to the two other conditions. The type of knowledge x informational status interaction was not significant (X2 = 2.62, p > .20). For F0 values, neither the effect of type of knowledge (X2 = 2.33, p = 0.13) nor the effect of information status (X2 = 4.68, p = .10) reached significance. The type of knowledge x informational status interaction was not significant (X2 = 0.93, p > .20). For both models there was no significant effect of the repetition when it was added to the models as a fixed factor (for duration values: X2 = 2.62, p > .20; for F0 values: X2 = 2.03).
Discussion
The aim of the present study was to investigate whether the manipulation of shared knowledge between interlocutors impacts the prosody produced by the speaker during semi-spontaneous interactions. We were interested in two kinds of prosodic variations: global prosodic variations that affect entire utterances (i.e., pitch range and speech rate variations) and more local prosodic variations that encode informational status of words (i.e., prosodic phrasing to encode the informational status of referents). To answer this question, we used a collaborative game in which we manipulated both the presence/absence of shared knowledge between a director and an addressee and the informational status of target words.
Based on previous studies, our first hypothesis was that, in the absence of shared knowledge, participants would modify their global prosodic features to facilitate addresses’ comprehension. In line with our hypothesis, we found that directors spoke more slowly and with larger pitch excursions when they did not necessarily share knowledge on target objects with their addressee than when they did it. This result corroborates studies from clear speech literature (see [12] for a review) by showing that directors adapt their prosodic production to their addressee when they are aware of potential speech perception difficulties on their part. It is important to note that our study did not explicitly test the mechanism underlying such accommodation process. However, we can speculatively offer some possibilities. An audience design explanation of the decrease of speech rate and increase of pitch span we observed is that speakers ‘clarified’ their speech to increase addressee understanding ([12]). Within this framework, speakers in the not-shared knowledge condition recognized that their addressees needed extra help. This realization may have triggered a speaking mode similar to ‘clear speech’ that provided additional information, which would help the addressee to complete the task. According to [12] clear speech modification refers to a distinct speaking style that speakers adopt when they are aware of a speech perception difficulty on the part of the listener due to background noise, a hearing impairment, or a different native language. All clear speech research converges on the idea that clear speech typically involves a wide range of acoustic/articulatory adjustments, including a decrease in speech rate (longer segments as well as longer and more frequent pauses), wider dynamic pitch range, greater sound-pressure levels, more salient stop releases, greater rms intensity of the non-silent portions of obstruent consonants, higher-voice intensity, vowel space expansion and vowel articulation. In our study, the not-shared knowledge condition induced a decrease in speech rate and a wider dynamic pitch range which are the two main acoustic adjustments observed in case of clear speech contexts. We can thus reasonably interpret these two modifications as resulting from an adjustment the speaker made because (s)he anticipated a perception difficulty from his/her conversational partner, which is exactly the definition of “clear speech”.
However, as for the majority of clear speech studies conducted in the past, we cannot exclude that the effect of not-shared knowledge in our study is not the result of audience design per se, but rather results from production constraints on the speaker’s part (see [13–15, 17]). Specifically, not-shared knowledge between interlocutors could have slowed down the planning process of speech which results in a decrease of the speaker’s speech rate and an increase of his/her pitch excursions. Our results are thus also consistent with a mechanism in which not-shared knowledge between interlocutors complicates production processes on the speaker’s part, rather than induce adjustment of prosodic forms on the basis of a specific representation of the addressee’s needs. Thus, research must be further developed to determine whether shared knowledge manipulation affects prosody of the speaker via planning effects or not.
Regardless of the mechanism underlying the effect of shared knowledge we observed on speech rate and pitch range, our result can also be interpreted in parallel with those of Rosa, Finch, Bergeson & Arnold [38]. In their study, speakers participated in two instruction-giving experiments in which they gave instructions to listeners to move objects to locations on a board. The attention of the listener was manipulated through the number of tasks in which they were involved: in the distraction condition, addressees might experience difficulties since they were also completing a demanding secondary computer task; in the attentive condition they paid full attention to the main task. The authors found that speakers use longer words for distracted listeners compared to attentive listeners. Since in our study we found more slowly speech rate (measured as number of syllables/s) and longer durations of the last syllable of target words when knowledge was not-shared between interlocutors compared to when it was shared, our result is in line with those of Rosa, Finch, Bergeson & Arnold, by showing that speakers modify duration of speech segments when they were aware of an interlocutor’s difficulty. For Rosa, Finch, Bergeson & Arnold, this perception difficulty consisted in distraction of listeners’ attention, while in our study, this perception difficulty was due to an absence of shared knowledge between interlocutors. However, it is important to note that in our study the modification of durations of the last syllable of target words resulted from a global speech rate modification. By contrast, in Rosa, Finch, Bergeson & Arnold’s study, this duration effect seems to be localized to the target word and does not appear to affect global speech rate. However, given that the authors have not explained how speech rate was calculated, one could argue that the different results obtained could be linked to the different portion of speech segments used to define speech rate. The entire fragment was used in our study whereas smaller portions of speech segments appear to have been used in Rosa, Finch, Bergeson & Arnold’s study. Moreover, it is interesting to notice that in both studies, duration of target words did not vary depending on whether target nouns were contrastive/unpredictable vs. non-contrastive/predictable, suggesting that in these two kinds of tasks, participants did not prosodically encode informational status of words.
Indeed, in our study, the observation that directors more often produced 1 AP phrasing (between 75% and 80%) rather than 2 AP phrasing whatever the knowledge shared by participants and the informational status of words was unexpected. Specifically, when knowledge was shared, we expected participants to prosodically encode the contrastive status of target nouns by producing target nouns in a separate AP from the following adjective. We thus expected more 2 AP phrasing in the contrastive noun condition compared to the contrastive adjective condition in the shared knowledge condition. By contrast, speakers did not increase their 2 AP phrasing productions regardless of the informational status of target noun and of the knowledge shared with their addressee. This result contrasts with previous studies in the field reporting that speakers phrased the contrastive information in a separate AP when knowledge is shared between interlocutors ([7, 8, 11]).
A way to explain this result is to consider the cognitive load of the task due to visual salience effects. Interestingly, [39, 40] showed an effect of the presence of visual competitors on linguistic choices of the speakers when an addressee was present while this visual effect of the competitor disappeared in the absence of an addressee. In their experimental paradigm, they manipulated the visual saliency of the referent by presenting a picture in which a visual competitor was present or not. The authors found an effect of the visual competitor on the choice of the referring expression: speakers used fewer pronouns and more repeated noun phrases when a visual competitor was present in the scene than when there was no visual competitor. The authors concluded that visual salience effects were due to adjustments that speakers make when they speak to an addressee. [41] did not find such adjustment to the addressee. Using a referential communication task, they showed that giving an explicit focus on addressee’s perspective did not influence reference production of the speaker. While speakers were able to engage in perspective taking, they did not use this knowledge during the task. In other words, they referred to their privileged knowledge, disregarding the addressee’s perspective. In the present study, visual context always contained two target objects and a competitor regardless of the type of knowledge condition. In line with [39, 40], we hypothesized that considering the visual context of the target objects (meaning the two target objects plus the competitor) would require a lot of attention making the task cognitively demanding for the director. Interestingly, in Michelas, Faget, Portes, Lienhart, Boyer, Lançon, et al. ([11)’s study in which control speakers prosodically encoded the informational status of referents, no competitor (i.e., no object of the same type but with a different color for the given noun condition and no object of the same color but a different type for the contrastive noun condition) was present in the map for each given location. The absence of such competitors in the visual context could have made the task less cognitively demanding for speakers than in the current study. Thus, assuming a high cognitive load of our task, it could be the case that directors were not able to keep track of the salience of objects (in terms of non-contrastive/contrastive status) and thus did not prosodically encode this salience. It is interesting to note that this difficulty of speakers under cognitive load to take discourse salience into account was also found by [42]. In this study, speakers under cognitive load (they had to spread attentional resources between two tasks) had more difficulties to use pronouns to refer to less salient referents than speakers who performed only one task. Similarly, in our task, it can be the case the speakers under cognitive load had chosen the most economical linguistic forms for themselves which consisted in not using prosodic phrasing to encode informational status of target nouns. But regardless of the cognitive load of our task, it is worth noting that in 100% of cases, the participants successfully completed the interactive task. There was no case in which the task was interrupted because of great difficulties to complete it. Moreover, it is interesting to note that in only 2% of cases, the confederate put the cross in the wrong place showing that in 98% of cases, speakers succeeded in guiding the confederate to put the cross in the right place. These two points reinforce the idea that the task we have created is not a burdensome task for the participants but that it requires more attentional resources than a task such as the one used by [11] in which the participants can focus on the prosodic encoding of the informational status of referents.
Interestingly, when taking a closer look at the acoustic cues of prosodic phrasing produced by our participants, we found an effect of shared-knowledge manipulations on duration of target syllables but not on height of these syllables. This effect confirms the fact that the increase in duration we observed in the not-shared condition resulted from global speech rate manipulation and did not occur specifically on target words. Indeed, if this modification of duration has translated variations of prosodic phrasing, we would have expected that the height of the syllable increased at the same time as the duration of this one. However, this was not the case and this confirms the relevance of the criteria we used to differentiate cases in which target nouns were produced in the same AP as the following adjectives (1 AP phrasing) from cases in which they were produced in a separate AP (2 AP phrasing; see also [11] for a similar procedure). Moreover, the fact that syllable duration did not vary as a function of the informational status of target words also indicates that the increase of target duration we observed reflects global speech rate modification and not acoustic prominence to encode informational status of words.
Concerning the speaker’s global prosodic modifications we observed in the not-shared condition, one could argue that these modifications could be impacted by the fact that, in our task, the addressee was a confederate. Indeed, we know the attributions that language users have about their task partner can impact how they adapt their language ([43]) and that using a confederate in the addressee role might be risky for studies of language in dialogue contexts ([44]). For these reasons, we run an additional pilot study using exactly the same procedure as previously described except that the additional participants interacted with other naïve participants and not a confederate (see S3 Appendix). These preliminary findings are in line with the current study and suggest that participants tended to modify their global prosodic variations (i.e., pitch range and speech rate variations) when speaking to naïve addressees in the same way as they did when speaking to a confederate while they tended to not prosodically encode the informational status of referents regardless of the knowledge condition. Thus, more research is now required to test our hypothesis that if the speaker has to take into account the possible visual competitors to give relevant information to his/her addressee each time s/he prepares the prosodic encoding of referents, s/he would probably not encode the informational status of these referents. In a more general manner, a large number of previous studies considers that the difficulty of the communicative task may influence the degree to which speakers appear to be modeling their listeners (see for instance [14, 15, 38, 39, 40, 45]). Thus, the next step of this research will be to determine the constraints under which speakers could be more/less sensitive to addressee’s knowledge.
To conclude, the present study reveals that in French the speaker’s knowledge of what the addressee knows or does not know affects his/her prosodic choices. When knowledge was not shared, we found that speakers modified their global prosody in terms of speech rate and pitch span modulations. However, and unexpectedly, we also found that speaker-internal constraints seemed to affect local prosodic encoding of informational status of words production since our participants who were involved in a more cognitive demanding task than in previous studies (e.g., [11]) did not modify their AP phrasing to encode pragmatic status of referents when knowledge was shared. These results are in line with the idea that complex reasoning usually implicated in constructing a model of the addressee co-exists with speaker-internal constraints such as cognitive load of the task to affect the production of speech ([14, 15]).
Supporting information
S1 Appendix [docx]
Complete instructions given to participants.S2 Appendix [docx]
Extract from the dialogue between one participant (the director) and the confederate (the addressee) corresponding to the screen views shown in .S3 Appendix [docx]
Pilot study including 5 additional participants that interacted with other naïve participant.S1 Fig [tiff]
Figure shown to participants during instructions.S2 Fig [tiff]
Figure shown to participants during instructions.
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- Research on OpenCL optimization for FPGA deep learning application
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- Improved survival rates in patients with H1N1 acute respiratory failure in Korea between 2009 and 2016
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- Relationship between feed efficiency indexes and performance, body measurements, digestibility, energy partitioning, and nitrogen partitioning in pre-weaning dairy heifers
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- The views and experiences of general dental practitioners (GDP’s) in West Yorkshire who used the International Caries Detection and Assessment System (ICDAS) in research
- Compare HIV/syphilis infections between age groups and explore associated factors of HIV/syphilis co-infections among men who have sex with men in Shenzhen, China, from 2009 to 2017
- Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers
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- Relationships between electrolyte and amino acid compositions in sweat during exercise suggest a role for amino acids and K+ in reabsorption of Na+ and Cl- from sweat
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- Correction: Perspectives of general dental practitioners on preventive, patient-centred, and evidence-based oral healthcare—A Q-methodology study
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- The effect of a hiding box on stress levels and body weight in Dutch shelter cats; a randomized controlled trial
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- Give science and peace a chance: Speeches by Nobel laureates in the sciences, 1901-2018
- The effect of food anticipation on cognitive function: An eye tracking study
- Adaptation of H3N2 canine influenza virus to feline cell culture
- A meta-analysis of crop response patterns to nitrogen limitation for improved model representation
- Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer’s mouse model are associated with hippocampal synaptic deficits in an age-dependent manner
- Does antibiotic use accelerate or retard cutaneous repair? A systematic review in animal models
- Transforming growth factor beta 1 induces methylation changes in lung fibroblasts
- Hepatic disease and the risk of mortality of Vibrio vulnificus necrotizing skin and soft tissue infections: A systematic review and meta-analysis
- Diagnostic accuracy of midkine on hepatocellular carcinoma: A meta-analysis
- Phosphorus-mediated alleviation of aluminum toxicity revealed by the iTRAQ technique in Citrus grandis roots
- Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization
- Management strategies for vaccinated animals after an outbreak of foot-and-mouth disease and the impact on return to trade
- RNA-Seq analysis reveals an essential role of tyrosine metabolism pathway in response to root-rot infection in Gerbera hybrida
- SpliceHetero: An information theoretic approach for measuring spliceomic intratumor heterogeneity from bulk tumor RNA-seq
- Large-scale phylogenomic analysis suggests three ancient superclades of the WUSCHEL-RELATED HOMEOBOX transcription factor family in plants
- Plasma sCD36 as non-circadian marker of chronic circadian disturbance in shift workers
- A cross sectional comparison of drug use indicators using WHO methodology in primary level hospitals participating in an Auditable Pharmaceutical Transactions and Services program versus non-APTS primary hospitals in Southern Ethiopia
- Trends in NBA and Euroleague basketball: Analysis and comparison of statistical data from 2000 to 2017
- Liquid biopsies for omics-based analysis in sentinel mussels
- Reporting biases in self-assessed physical and cognitive health status of older Europeans
- Trends in the characteristics of acute primary angle closure in Korea over the past 10-years
- Obesity-associated insulin resistance adversely affects skin function
- First-line treatments in EGFR-mutated advanced non-small cell lung cancer: A network meta-analysis
- In vivo human lower limb muscle architecture dataset obtained using diffusion tensor imaging
- Tobacco smoke exposure as a risk factor for human papillomavirus infections in women 18-26 years old in the United States
- The trigger-information-response model: Exploring health literacy during the first six months following a kidney transplantation
- Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance
- The development of an evidence-based street food vending model within a socioecological framework: A guide for African countries
- Sociodemographic changes and trends in the rates of new perinatal HIV diagnoses and transmission in Spain from 1997 to 2015
- Patient navigation services for cancer care in low-and middle-income countries: A scoping review
- Weather extremes and perinatal mortality – Seasonal and ethnic differences in northern Sweden, 1800-1895
- Cognitive, relational and task crafting: Spanish adaptation and analysis of psychometric properties of the Job Crafting Questionnaire
- Maternal and perinatal death surveillance and response in Ethiopia: Achievements, challenges and prospects
- Identification and characterisation of capidermicin, a novel bacteriocin produced by Staphylococcus capitis
- Joint emulation of Earth System Model temperature-precipitation realizations with internal variability and space-time and cross-variable correlation: fldgen v2.0 software description
- Extensive culturomics of 8 healthy samples enhances metagenomics efficiency
- Macroepidemiological aspects of porcine reproductive and respiratory syndrome virus detection by major United States veterinary diagnostic laboratories over time, age group, and specimen
- Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
- Correction: Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants
- Myofibrillar function differs markedly between denervated and dexamethasone-treated rat skeletal muscles: Role of mechanical load
- Quantitation of eumelanin and pheomelanin markers in diverse biological samples by HPLC-UV-MS following solid-phase extraction
- Kinetics of mean platelet volume predicts mortality in patients with septic shock
- An integrated epigenome and transcriptome analysis identifies PAX2 as a master regulator of drug resistance in high grade pancreatic ductal adenocarcinoma
- Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity
- Association of Medicaid expansion with health insurance coverage by marital status and sex
- Are current approaches for measuring access to clean water and sanitation inclusive of people with disabilities? Comparison of individual- and household-level access between people with and without disabilities in the Tanahun district of Nepal
- A proteomic clock for malignant gliomas: The role of the environment in tumorigenesis at the presymptomatic stage
- Monitoring Universal Health Coverage (UHC) in high Tuberculosis burden countries: Tuberculosis mortality an important tracer of UHC service coverage
- RCT evaluation of Skhokho: A holistic school intervention to prevent gender-based violence among South African Grade 8s
- On the use of Action Units and fuzzy explanatory models for facial expression recognition
- A systematic review of complementary and alternative medicine in oncology: Psychological and physical effects of manipulative and body-based practices
- What factors best explain attitudes to snow leopards in the Nepal Himalayas?
- Determinants of temperature sensitivity of soil respiration with the decline of a foundation species
- Mindfulness meditation, time judgment and time experience: Importance of the time scale considered (seconds or minutes)
- Regional, institutional, and departmental factors associated with gender diversity among BS-level chemical and electrical engineering graduates
- Transepithelial transport of P-glycoprotein substrate by the Malpighian tubules of the desert locust
- Sex affects immunolabeling for histone 3 K27me3 in the trophectoderm of the bovine blastocyst but not labeling for histone 3 K18ac
- A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan
- Replacing plasma membrane outer leaflet lipids with exogenous lipid without damaging membrane integrity
- Accurate dried blood spots collection in the community using non-medically trained personnel could support scaling up routine viral load testing in resource limited settings
- Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study
- Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review
- The motility-based swim-up technique separates bull sperm based on differences in metabolic rates and tail length
- Synbiotic supplementation to decrease Salmonella colonization in the intestine and carcass contamination in broiler birds
- Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease
- States with higher minimum wages have lower STI rates among women: Results of an ecological study of 66 US metropolitan areas, 2003-2015
- Weakening the subjective sensation of own hand ownership does not interfere with rapid finger movements
- Identification of DNA methyltransferases and demethylases in Solanum melongena L., and their transcription dynamics during fruit development and after salt and drought stresses
- Environmental conditions for Jamestown Canyon virus correlated with population-level resource selection by white-tailed deer in a suburban landscape
- The contribution of linear perspective cues and texture gradients in the perceptual rescaling of stimuli inside a Ponzo illusion corridor
- Cerebral blood flow imbalance is associated with motor outcome after pediatric arterial ischemic stroke
- Particularly neglected in countries with other challenges: High Toxoplasma gondii seroprevalence in pregnant women in Kabul, Afghanistan, while a low proportion know about the parasite
- Implementing advance care planning in routine nursing home care: The development of the theory-based ACP+ program
- Identifying genetic lineages through shape: An example in a cosmopolitan marine turtle species using geometric morphometrics
- The causality of borrowing: Lexical loans in Eurasian languages
- The uptake of the pharmacy-dispensed naloxone kit program in Ontario: A population-based study
- Gaze and body cues interplay during interactive requests
- Acetylcholine-mediated top-down attention improves the response to bottom-up inputs by deformation of the attractor landscape
- Deep architectures for long-term stock price prediction with a heuristic-based strategy for trading simulations
- Vaccination status of patients using anti-TNF therapy and the physicians’ behavior shaping the phenomenon: Mixed-methods approach
- Organizational justice and illness reporting among Japanese employees with chronic diseases
- CavBench: A benchmark for protein cavity detection methods
- Antimicrobial resistance (AMR) and molecular characterization of Neisseria gonorrhoeae in Ghana, 2012-2015
- Prevalence of methicillin-resistant Staphylococcus aureus in healthy Chinese population: A system review and meta-analysis
- Suppression treatment differentially influences the microbial community and the occurrence of broad host range plasmids in the rhizosphere of the model cover crop Avena sativa L.
- Risk of pneumonia among residents living near goat and poultry farms during 2014-2016
- Lipid levels after childbirth and association with number of children: A population-based cohort study
- Birth outcomes in women who have taken adalimumab in pregnancy: A prospective cohort study
- ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
- Effects of dietary intake and nutritional status on cerebral oxygenation in patients with chronic kidney disease not undergoing dialysis: A cross-sectional study
- Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
- Flexible learning spaces facilitate interaction, collaboration and behavioural engagement in secondary school
- Clinical significance and prognostic role of hypoxia-induced microRNA 382 in gastric adenocarcinoma
- Genome-wide investigation of superoxide dismutase (SOD) gene family and their regulatory miRNAs reveal the involvement in abiotic stress and hormone response in tea plant (Camellia sinensis)
- Classifying recurrent Mycobacterium tuberculosis cases in Georgia using MIRU-VNTR typing
- Prevalence of Trypanosoma cruzi infection in active military population of The Colombian National Army gathered in five departments
- An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway
- Sarcopenia as a prognostic factor for survival in patients with locally advanced gastroesophageal adenocarcinoma
- Increased aggression and reduced aversive learning in honey bees exposed to extremely low frequency electromagnetic fields
- Attending to design when developing complex health interventions: A qualitative interview study with intervention developers and associated stakeholders
- Increased fecundity of Aphis fabae on Vicia faba plants following seed or leaf inoculation with the entomopathogenic fungus Beauveria bassiana
- Is summer food intake a limiting factor for boreal browsers? Diet, temperature, and reproduction as drivers of consumption in female moose
- Characterization of sound scattering layers in the Bay of Biscay using broadband acoustics, nets and video
- Conducting human challenge studies in LMICs: A survey of researchers and ethics committee members in Thailand
- eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization
- Clinical use of SAND battery to evaluate language in patients with Progressive Supranuclear Palsy
- The interplay of personality and attitudes toward own aging across two decades of later life
- Robust automated reading of the skin prick test via 3D imaging and parametric surface fitting
- Reconstructing the population history of the sandy beach amphipod Haustorioides japonicus using the calibration of demographic transition (CDT) approach
- A psychoacoustic application for the adjustment of electrical hearing thresholds in cochlear implant patients
- Correction: Blue light-dependent human magnetoreception in geomagnetic food orientation
- Re-evaluation of a Tn5::gacA mutant of Pseudomonas syringae pv. tomato DC3000 uncovers roles for uvrC and anmK in promoting virulence
- Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study
- Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma
- The impact of shared knowledge on speakers’ prosody
- Effects of insecticides, fipronil and imidacloprid, on the growth, survival, and behavior of brown shrimp Farfantepenaeus aztecus
- Prevalence of pectus excavatum (PE), pectus carinatum (PC), tracheal hypoplasia, thoracic spine deformities and lateral heart displacement in thoracic radiographs of screw-tailed brachycephalic dogs
- Validation of the vignette-based German Exercise Causality Orientation Scale (G-ECOS)
- Hierarchical classification of snowmelt episodes in the Pyrenees using seismic data
- A national survey of videolaryngoscopes and alternative intubation devices in Hungary
- The relevance of U.S. Strategic Highway Safety Plans in a future context
- Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs
- Anti-inflammatory effects induced by ultralow concentrations of bupivacaine in combination with ultralow concentrations of sildenafil (Viagra) and vitamin D3 on inflammatory reactive brain astrocytes
- Access to unauthorized hepatitis C generics: Perception and knowledge of physicians, pharmacists, patients and non-healthcare professionals
- Urban commuting dynamics in response to public transit upgrades: A big data approach
- Intestinal mucosal injury induced by obstructive jaundice is associated with activation of TLR4/TRAF6/NF-κB pathways
- When resolution does matter: Modelling indirect contacts in dairy farms at different levels of detail
- Molecular epidemiology of Mycoplasma hyorhinis porcine field isolates in the United States
- Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation
- Adolescents living with HIV are at higher risk of death and loss to follow up from care: Analysis of cohort data from eight health facilities in Ethiopia
- Identification of social relation within pedestrian dyads
- Blood donation and health status based on SF-36: The mediating effect of cognition in blood donation
- The cost-effectiveness of controlling cervical cancer using a new 9-valent human papillomavirus vaccine among school-aged girls in Australia
- Inactivation of chronic wasting disease prions using sodium hypochlorite
- Analysing linear multivariate pattern transformations in neuroimaging data
- Ecological aesthetic assessment of a rebuilt wetland restored from farmland and management implications for National Wetland Parks
- A method for predicting background advertisement exposure parameters in sporting events: Televised football game approach
- Self-reported and experimentally induced self-disgust is heightened in Parkinson’s disease: Contribution of behavioural symptoms
- Associations between nocturnal sleep duration, midday nap duration and body composition among adults in Southwest China
- Short-term effects of video gaming on brain response during working memory performance
- Molecular detection and genetic characterization of Bartonella species from rodents and their associated ectoparasites from northern Tanzania
- Estimation of the number of HCV-positive patients in Italy
- Comparative cost analysis of point-of-care versus laboratory-based testing to initiate and monitor HIV treatment in South Africa
- Insights into the behavior of six rationally designed peptides based on Escherichia coli’s OmpA at the water-dodecane interface
- Identification of muscle-specific candidate genes in Simmental beef cattle using imputed next generation sequencing
- A game theoretic setting of capitation versus fee-for-service payment systems
- In utero exposure to economic fluctuations and birth outcomes: An analysis of the relevance of the local unemployment rate in Brazilian state capitals
- QTL mapping for aluminum tolerance in RIL population of soybean (Glycine max L.) by RAD sequencing
- Establishing an infrastructure for collaboration in primate cognition research
- Evaluation of left ventricular dimension and systolic function by standard transthoracic echocardiography before and 24-hours after percutaneous closure of patent ductus arteriosus in 120 dogs
- Modeling environmental variability and network formation among pastoral nomadic households: Implications for the rise of the Mongol Empire
- Changes in real-life practice for hepatocellular carcinoma patients in the Republic of Korea over a 12-year period: A nationwide random sample study
- Correction: Homology analysis of malware based on ensemble learning and multifeatures
- Illness beliefs and emotional responses in mildly disabled stroke survivors: A qualitative study
- Extended-wavelength diffuse reflectance spectroscopy with a machine-learning method for in vivo tissue classification
- Modeling the natural history of fatty liver using lifestyle–related risk factors: Effects of body mass index (BMI) on the life–course of fatty liver
- Development of a recombinant replication-deficient rabies virus-based bivalent-vaccine against MERS-CoV and rabies virus and its humoral immunogenicity in mice
- Educational achievement at age 9.5 years of children born to mothers maintained on methadone during pregnancy
- Comparative transcriptome analysis of galls from four different host plants suggests the molecular mechanism of gall development
- Experiences with peer support for breastfeeding in Beirut, Lebanon: A qualitative study
- Elucidating optical field directed hierarchical self-assembly of homogenous versus heterogeneous nanoclusters with femtosecond optical tweezers
- Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer
- Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality
- Correction: Functional atlases for analysis of motor and neuropsychological outcomes after medial globus pallidus and subthalamic stimulation
- Correction: Estimating Body Composition in Adolescent Sprint Athletes: Comparison of Different Methods in a 3 Years Longitudinal Design
- Quality of labor and birth care in Sindh Province, Pakistan: Findings from direct observations at health facilities
- A comparison of sLASER and MEGA-sLASER using simultaneous interleaved acquisition for measuring GABA in the human brain at 7T
- Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis
- Intrabladder pressure as predictor of intra-abdominal pressure in horses
- Pollock avoided hydrodynamic instabilities to paint with his dripping technique
- Metabolomic analysis of the occurrence of bitter fruits on grafted oriental melon plants
- Photo-degradation dynamics of five neonicotinoids: Bamboo vinegar as a synergistic agent for improved functional duration
- Use of acoustic emission to identify novel candidate biomarkers for knee osteoarthritis (OA)
- Cetacean biodiversity, spatial and temporal trends based on stranding records (1920-2016), Victoria, Australia
- Neutrophil elastase inhibitor purification strategy from cowpea seeds
- Correction: Hafting of Middle Paleolithic tools in Latium (central Italy): New data from Fossellone and Sant’Agostino caves
- Coherent poly propagation materials with 3-dimensional photonic control over visible light
- Characterization of Worldwide Olive Germplasm Banks of Marrakech (Morocco) and Córdoba (Spain): Towards management and use of olive germplasm in breeding programs
- Can non-pharmacological interventions reduce hospital admissions in people with dementia? A systematic review
- Metarhizium robertsii ammonium permeases (MepC and Mep2) contribute to rhizoplane colonization and modulates the transfer of insect derived nitrogen to plants
- Genotyping and antimicrobial resistance of Streptococcus uberis isolated from bovine clinical mastitis
- Isotopic compositions of ground ice in near-surface permafrost in relation to vegetation and microtopography at the Taiga–Tundra boundary in the Indigirka River lowlands, northeastern Siberia
- Financial inclusion and intimate partner violence: What does the evidence suggest?
- Are intestinal helminths playing a positive role in tuberculosis risk? A systematic review and meta-analysis
- Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition
- Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer
- Take one step backward to move forward: Assessment of genetic diversity and population structure of captive Asian woolly-necked storks (Ciconia episcopus)
- Money doesn’t matter! Householders’ intentions to reduce standby power are unaffected by personalised pecuniary feedback
- Validating a scale to measure engineers’ perceived self-efficacy for engineering education outreach
- Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder
- Nursing students and nurses’ knowledge and attitudes regarding children’s pain: A comparative cross-sectional study
- Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum
- Knowledge, attitudes and medical practice regarding hepatitis B prevention and management among healthcare workers in Northern Vietnam
- Development and validation of a symptom assessment tool for postmicturition dribble: A prospective, multicenter, observational study in Korea
- Identification of closely related Ixodes species by protein profiling with MALDI-TOF mass spectrometry
- When calculators lie: A demonstration of uncritical calculator usage among college students and factors that improve performance
- Socio-economic characteristics and career intentions of the WiSDOM health professional cohort in South Africa
- Correction: Neural computational model GrowthEstimate: A model for studying living resources through digestive efficiency
- Social proximity in dairy calves is affected by differences in pessimism
- Amphibian skin-associated Pigmentiphaga: Genome sequence and occurrence across geography and hosts
- Expanded consumer niche widths may signal an early response to spatial protection
- Moral grandstanding in public discourse: Status-seeking motives as a potential explanatory mechanism in predicting conflict
- Adipose stem cells in reparative goat mastitis mammary gland
- Seventy-five mosses and liverworts found frozen with the late Neolithic Tyrolean Iceman: Origins, taphonomy and the Iceman’s last journey
- Hyaluronic acid and epidermal growth factor improved the bovine embryo quality by regulating the DNA methylation and expression patterns of the focal adhesion pathway
- Associations among knowledge, attitudes, and practices toward palliative care consultation service in healthcare staffs: A cross-sectional study
- A novel, wearable, electronic visual aid to assist those with reduced peripheral vision
- Genetic diversity and population structure of the Mediterranean sesame core collection with use of genome-wide SNPs developed by double digest RAD-Seq
- Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression
- Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Factors influencing cultivated ginseng (Panax ginseng C. A. Meyer) bioactive compounds
- Estimation of soil pH with geochemical indices in forest soils
- Multiplexed editing of a begomovirus genome restricts escape mutant formation and disease development
- Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures
- Collaboration and followership: A stochastic model for activities in social networks
- Evaluating access to oral anti-diabetic medicines: A cross-sectional survey of prices, availability and affordability in Shaanxi Province, Western China
- Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles
- Use of a pressure-sensing walkway system for biometric assessment of gait characteristics in goats
- Current status and direct medical cost of amyotrophic lateral sclerosis in the region of Catalonia: A population-based analysis
- Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
- Can work climate foster pro-environmental behavior inside and outside of the workplace?
- Gene editing of PKLR gene in human hematopoietic progenitors through 5’ and 3’ UTR modified TALEN mRNA
- Pelvic alignment changes during the perinatal period
- Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
- Life-course trajectories of body mass index and subsequent cardiovascular risk among Chinese population
- Inhibitory interaction networks among coevolved Streptomyces populations from prairie soils
- Exploiting contextual information to improve call prediction
- Visual inputs decrease brain activity in frontal areas during silent lipreading
- The synergistic effects of TaAGP.L-B1 and TaSSIVb-D mutations in wheat lead to alterations of gene expression patterns and starch content in grain development
- Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets
- Robust, real-time generic detector based on a multi-feature probabilistic method
- Maize leaves drought-responsive genes revealed by comparative transcriptome of two cultivars during the filling stage
- Xenon lamps used for fruit surface sterilization can increase the content of total flavonols in leaves of Lactuca sativa L. without any negative effect on net photosynthesis
- An alternative procedure to obtain the mortality rate with non-linear functions: Application to the case of the Spanish population
- Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
- Longitudinal assessment of post-surgical physical activity in endometrial and ovarian cancer patients
- THINGS: A database of 1,854 object concepts and more than 26,000 naturalistic object images
- Evaluation of ranibizumab and aflibercept for the treatment of diabetic macular edema in daily clinical practice
- Proteomic analysis of Escherichia coli detergent-resistant membranes (DRM)
- Correction: Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor
- Correction: Predicting childhood obesity using electronic health records and publicly available data
- Correction: Estimating the value of tropical coastal wetland habitats to fisheries: Caveats and assumptions
- Correction: The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- Determinants of frailty development and progression using a multidimensional frailty index: Evidence from the English Longitudinal Study of Ageing
- Supporting informed clinical trial decisions: Results from a randomized controlled trial evaluating a digital decision support tool for those with intellectual disability
- BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin
- Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Hepatopulmonary syndrome has low prevalence of pulmonary vascular abnormalities on chest computed tomography
- Early and long-term outcomes of coronary artery bypass surgery with and without use of heart-lung machine and with special respect to renal function - A retrospective study
- Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
- The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population
- Expression of Concern: The Coordination of Cell Growth during Fission Yeast Mating Requires Ras1-GTP Hydrolysis
- Correction: Lentivirus-Mediated Knockdown of Astrocyte Elevated Gene-1 Inhibits Growth and Induces Apoptosis through MAPK Pathways in Human Retinoblastoma Cells
- Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
- Remarkable cell recovery from cerebral ischemia in rats using an adaptive escalator-based rehabilitation mechanism
- Integrating environmental and neighborhood factors in MaxEnt modeling to predict species distributions: A case study of Aedes albopictus in southeastern Pennsylvania
- Post-overdose interventions triggered by calling 911: Centering the perspectives of people who use drugs (PWUDs)
- The prevalence of intimate partner violence among couples signing up for universally offered parent preparation
- Analysis of gear surface morphology based on gray level co-occurrence matrix and fractal dimension
- Abiotic, present-day and historical effects on species, functional and phylogenetic diversity in dry grasslands of different age
- Clonality analysis of pulmonary tumors by genome-wide copy number profiling
- A relictual troglomorphic harvestman discovered in a volcanic cave of western Argentina: Otilioleptes marcelae, new genus, new species, and Otilioleptidae, new family (Arachnida, Opiliones, Gonyleptoidea)
- HIV drug resistance in persons who inject drugs enrolled in an HIV prevention trial in Indonesia, Ukraine, and Vietnam: HPTN 074
- Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery
- Regulation of nitrogen availability results in changes in grain protein content and grain storage subproteomes in barley (Hordeum vulgare L.)
- Diagnostic test evaluation methodology: A systematic review of methods employed to evaluate diagnostic tests in the absence of gold standard – An update
- Longitudinal trends of and factors associated with inappropriate antibiotic prescribing for non-bacterial acute respiratory tract infection in Japan: A retrospective claims database study, 2012–2017
- Revealing users’ experience and social interaction outcomes following a web-based smoking prevention intervention for adolescents: A qualitative study
- Coordination of human movements resulting in motor strategies exploited by skilled players during a throwing task
- Impact of pericardiectomy on exercise capacity and sleep of patients with chronic constrictive pericarditis
- Blue-violet light decreases VEGFa production in an in vitro model of AMD
- Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach
- Speed of processing training and depression in assisted and independent living: A randomized controlled trial
- Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient
- What happens in the brain of meditators when perception changes but not the stimulus?
- Comparison of HIV-1 Vif and Vpu accessory proteins for delivery of polyepitope constructs harboring Nef, Gp160 and P24 using various cell penetrating peptides
- Are degree of urbanisation and travel times to healthcare services associated with the processes of care and outcomes of heart failure? A retrospective cohort study based on administrative data
- A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing
- Influence of transcutaneous vagus nerve stimulation on cardiac vagal activity: Not different from sham stimulation and no effect of stimulation intensity
- Co-prescription network reveals social dynamics of opioid doctor shopping
- Contractile properties of superficial skeletal muscle affect postural control in healthy young adults: A test of the rambling and trembling hypothesis
- Does intrauterine crowding affect the force generating capacity and muscle composition of the piglet front limb?
- Correction: Measuring compassionate healthcare with the 12-item Schwartz Center Compassionate Care Scale
- Facilitators and barriers to traditional medicine use among cancer patients in Malawi
- Expression of CMV protein pp65 in cutaneous malignant melanoma
- The evolution of mental health outcomes across a combat deployment cycle: A longitudinal study of a Guam-based National Guard unit
- Caesarean section delivery and childhood obesity in a British longitudinal cohort study
- Incidence, characteristics, and mortality of infective endocarditis in France in 2011
- Pfcyp51 exclusively determines reduced sensitivity to 14α-demethylase inhibitor fungicides in the banana black Sigatoka pathogen Pseudocercospora fijiensis
- Evaluation of the bacterial ocular surface microbiome in clinically normal cats before and after treatment with topical erythromycin
- Histological and developmental insights into the herbivorous dentition of tapinocephalid therapsids
- Differential immunomodulation of T-cells by immunoglobulin replacement therapy in primary and secondary antibody deficiency
- A longitudinal study on perceived health in cardiovascular patients: The role of conscientiousness, subjective wellbeing and cardiac self-efficacy
- The effectiveness of interferon beta versus glatiramer acetate and natalizumab versus fingolimod in a Polish real-world population
- Interactions of Streptococcus suis serotype 9 with host cells and role of the capsular polysaccharide: Comparison with serotypes 2 and 14
- Honey bee and native solitary bee foraging behavior in a crop with dimorphic parental lines
- A flexible formula for incorporating distributive concerns into cost-effectiveness analyses: Priority weights
- Correction: Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- A reconnaissance survey of farmers’ awareness of hypomagnesaemic tetany in UK cattle and sheep farms
- Health workers’ perception of malaria rapid diagnostic test and factors influencing compliance with test results in Ebonyi state, Nigeria
- Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods
- The increasing importance of fellowships and career development awards in the careers of early-stage biomedical academic researchers
- Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components
- Auxin driven indoleamine biosynthesis and the role of tryptophan as an inductive signal in Hypericum perforatum (L.)
- Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development
- Distance to large rivers affects fish diversity patterns in highly dynamic streams of Central Amazonia
- Real vs. immersive-virtual emotional experience: Analysis of psycho-physiological patterns in a free exploration of an art museum
- Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study
- Processed meat intake and chronic disease morbidity and mortality: An overview of systematic reviews and meta-analyses
- Modeling ENSO impact on rice production in the Mekong River Delta
- The feasibility of a behavioral group intervention after weight-loss surgery: A randomized pilot trial
- EMR-integrated minimal core dataset for routine health care and multiple research settings: A case study for neuroinflammatory demyelinating diseases
- A review of a 13-month period of FilmArray Meningitis/Encephalitis panel implementation as a first-line diagnosis tool at a university hospital
- Increased BMI has a linear association with late-onset preeclampsia: A population-based study
- Autoantibody production significantly decreased with APRIL/BLyS blockade in murine chronic rejection kidney transplant model
- Vancomycin-resistance gene cluster, vanC, in the gut microbiome of acute leukemia patients undergoing intensive chemotherapy
- Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
- Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP
- Impact of faecal calprotectin measurement on clinical decision-making in patients with Crohn’s disease and ulcerative colitis
- Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells
- Autophagy is important to the acidogenic metabolism of Aspergillus niger
- Continuous ratings of movie watching reveal idiosyncratic dynamics of aesthetic enjoyment
- Sensitivity and specificity of serum soluble interleukin-2 receptor for diagnosing sarcoidosis in a population of patients suspected of sarcoidosis
- Enhancing genomic selection by fitting large-effect SNPs as fixed effects and a genotype-by-environment effect using a maize BC1F3:4 population
- Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry
- Microbial induced solidification and stabilization of municipal solid waste incineration fly ash with high alkalinity and heavy metal toxicity
- Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses
- A fault-tolerant aware scheduling method for fog-cloud environments
- Correction: BCG vaccination and tuberculosis prevention: A forty years cohort study, Monastir, Tunisia
- Correction: Perceptions among transgender women of factors associated with the access to HIV/AIDS-related health services in Yogyakarta, Indonesia
- Assessing the convergent validity between the automated emotion recognition software Noldus FaceReader 7 and Facial Action Coding System Scoring
- Deep learning based banana plant detection and counting using high-resolution red-green-blue (RGB) images collected from unmanned aerial vehicle (UAV)
- Comparison of cardiorespiratory fitness between preschool children with normal and excess body adipose ~ An observational study
- Intraregional differences in renal function in the Northern Netherlands: The Lifelines Cohort Study
- Effects of MCHM on yeast metabolism
- Signaling impacts of GMO labeling on fruit and vegetable demand
- Dietary specialization depending on ecological context and sexual differences in Asiatic black bears
- Electronic device use and beverage related sugar and caffeine intake in US adolescents
- Isolation and characterization of five novel probiotic strains from Korean infant and children faeces
- Correction: Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Correction: Anatomical analysis of antebrachial cutaneous nerve distribution pattern and its clinical implications for sensory reconstruction
- Endothelial nitric oxide synthase limits host immunity to control disseminated Candida albicans infections in mice
- Lack of detection of Candida nivariensis and Candida bracarensis among 440 clinical Candida glabrata sensu lato isolates in Kuwait
- Nonlinear dynamics captures brain states at different levels of consciousness in patients anesthetized with propofol
- Visual encounters on line transect surveys under-detect carnivore species: Implications for assessing distribution and conservation status
- Menstrual health communication among Indian adolescents: A mixed-methods study
- Fast fluorescence in situ hybridisation for the enhanced detection of MET in non-small cell lung cancer
- The influence of personality on the effect of iTBS after being stressed on cortisol secretion
- Parental and peer support and modelling in relation to domain-specific physical activity participation in boys and girls from Germany
- Oral delivery of water-soluble compounds to the phytoseiid mite Neoseiulus californicus (Acari: Phytoseiidae)
- Force perceptual bias caused by muscle activity in unimanual steering
- Correction: Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Correction: Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium
- Providencia entomophila sp. nov., a new bacterial species associated with major olive pests in Tunisia
- Safety of intravitreal ziv-aflibercept in choroido-retinal vascular diseases: A randomised double-blind intervention study
- A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic
- Reduction of the rocuronium-induced withdrawal reflex by MR13A10A, a generic rocuronium with a novel solution: A randomized, controlled study
- Emotionally expressed voices are retained in memory following a single exposure
- Megabenthic communities of the Ligurian deep continental shelf and shelf break (NW Mediterranean Sea)
- Election forensics: Using machine learning and synthetic data for possible election anomaly detection
- A randomized crossover trial comparing the Nifty cup to a medicine cup in preterm infants who have difficulty breastfeeding at Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana
- The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease
- Genomic impact of severe population decline in a nomadic songbird
- Evolution of high-sensitivity troponin-T and echocardiography parameters in patients undergoing high efficiency on-line hemodiafiltration versus conventional low-flux hemodialysis
- Full genome characterization of 12 citrus tatter leaf virus isolates for the development of a detection assay
- Intake of myo-inositol hexaphosphate and urinary excretion of inositol phosphates in Wistar rats: Gavage vs. oral administration with sugar
- Enhancing financial security of female sex workers through a community-led intervention in India: Evidence from a longitudinal survey
- In-silico prediction of novel genes responsive to drought and salinity stress tolerance in bread wheat (Triticum aestivum)
- Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America
- Partitioning the risk of tuberculosis transmission in household contact studies
- Recommendation system in social networks with topical attention and probabilistic matrix factorization
- Using satellite-measured relative humidity for prediction of Metisa plana’s population in oil palm plantations: A comparative assessment of regression and artificial neural network models
- A drug interaction study investigating the effect of Rifabutin on the pharmacokinetics of Maraviroc in healthy subjects
- Emotional and behavioral problems, social competence and risk factors in 6–16-year-old students in Beijing, China
- Clinicopathologic and prognostic significance of tumor-associated macrophages in patients with hepatocellular carcinoma: A meta-analysis
- Involution of retinopathy of prematurity and neurodevelopmental outcomes after intravitreal bevacizumab treatment
- Travel demand and distance analysis for free-floating car sharing based on deep learning method
- Genome-wide identification, characterization, expression and enzyme activity analysis of coniferyl alcohol acetyltransferase genes involved in eugenol biosynthesis in Prunus mume
- Population analysis of D6-like plasmid prophage variants associated with specific IncC plasmid types in the emerging Salmonella Typhimurium ST213 genotype
- The high resource impact of reformatting requirements for scientific papers
- Egg yolk-free cryopreservation of bull semen
- Fine epitope mapping of glycoprotein Gn in Guertu virus
- Are hospital nurse staffing practices associated with postoperative cardiac events and death? A systematic review
- Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction
- Aging and the wandering brain: Age-related differences in the neural correlates of stimulus-independent thoughts
- Elucidating stygofaunal trophic web interactions via isotopic ecology
- Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases
- Scientist and data architect collaborate to curate and archive an inner ear electrophysiology data collection
- No effect of triple-pulse TMS medial to intraparietal sulcus on online correction for target perturbations during goal-directed hand and foot reaches
- Correction: Controlling Social Stress in Virtual Reality Environments
- TNF-α is responsible for the contribution of stromal cells to osteoclast and odontoclast formation during orthodontic tooth movement
- Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children
- Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease
- To tweet or not to tweet, that is the question: A randomized trial of Twitter effects in medical education
- Visualizing a field of research: A methodology of systematic scientometric reviews
- True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential
- Impact of the detection of ζ-globin chains and hemoglobin Bart’s using immunochromatographic strip tests for α0-thalassemia (--SEA) differential diagnosis
- Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort
- Correction: Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Correction: Lower prevalence of Blastocystis sp. infections in HIV positive compared to HIV negative adults in Ghana
- Correction: Precision public health: Mapping socioeconomic disparities in opioid dispensations at Swedish pharmacies by Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA)
- Epidemiological, clinical and laboratory characteristics of the measles resurgence in the Republic of Serbia in 2014-2015
- Macro-charcoal accumulation in floodplain wetlands: Problems and prospects for reconstruction of fire regimes and environmental conditions
- Stage at diagnosis and stage-specific survival of breast cancer in Latin America and the Caribbean: A systematic review and meta-analysis
- Correction: Retraction: Stiffening-Induced High Pulsatility Flow Activates Endothelial Inflammation via a TLR2/NF-κB Pathway
- TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo
- Clinical impact of intraoperative hyperlactatemia during craniotomy
- Intubation with channeled versus non-channeled video laryngoscopes in simulated difficult airway by junior doctors in an out-of-hospital setting: A crossover manikin study
- Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates
- Sex-specific differences in risk factors of lymph node metastasis in patients with early gastric cancer
- The impact of electroconvulsive therapy on the spatial QRS-T angle and cardiac troponin T concentration in psychiatric patients
- BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss
- Investigation on the hereditary basis of colorectal cancers in an African population with frequent early onset cases
- Comparison of cancer prevalence between patients with glomerulonephritis and the general population at the time of kidney biopsy
- Predictors of time to unfavorable treatment outcomes among patients with multidrug resistant tuberculosis in Oromia region, Ethiopia
- Experimentally validated simulation of coronary stents considering different dogboning ratios and asymmetric stent positioning
- The membrane effects of melittin on gastric and colorectal cancer
- Exclusive breastfeeding policy, practice and influences in South Africa, 1980 to 2018: A mixed-methods systematic review
- Hippocampal subfield volumes and pre-clinical Alzheimer’s disease in 408 cognitively normal adults born in 1946
- Uncorrected low hyperopia in young subjects induces postural instability even in those with clear visual acuity
- Membrane associated proteins of two Trichomonas gallinae clones vary with the virulence
- Awareness, current use of electronic cigarettes and associated smoking factors in Zhejiang Chinese adolescents
- Associations between pre-pregnancy BMI, gestational weight gain, and prenatal diet quality in a national sample
- Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children
- Optofluidic laser speckle image decorrelation analysis for the assessment of red blood cell storage
- Complete chloroplast genome sequence and phylogenetic analysis of Spathiphyllum 'Parrish'
- Strategic science communication as planned behavior: Understanding scientists’ willingness to choose specific tactics
- Understanding spatial patterns of soils for sustainable agriculture in northern Ethiopia’s tropical mountains
- Does Japan’s national nutrient-based dietary guideline improve lifestyle-related disease outcomes? A retrospective observational cross-sectional study
- Agitation near the end of life with dementia: An ethnographic study of care
- Tick-borne encephalitis virus infections in Germany. Seasonality and in-year patterns. A retrospective analysis from 2001-2018
- Encouraging perspective taking: Using narrative writing to induce empathy for others engaging in negative health behaviors
- Considerations of target surface area and the risk of radiosurgical toxicity
- Correction: A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells
- Effect of using immobilization device in fluoroscopic study in pediatric patient: Focused on radiation dose reduction in voiding cystourethrogram
- Temporal trends in breast cancer survival by race and ethnicity: A population-based cohort study
- Contamination of hospital surfaces with respiratory pathogens in Bangladesh
- The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver
- Association between hospital interval and survival in patients with oral cancer: A waiting time paradox
- Translating a stress management intervention for rural Latina breast cancer survivors: The Nuevo Amanecer-II
- Comprehensive management of obstructive sleep apnea by telemedicine: Clinical improvement and cost-effectiveness of a Virtual Sleep Unit. A randomized controlled trial
- Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning
- Harnessing therapeutic viruses as a delivery vehicle for RNA-based therapy
- Korean soybean core collection: Genotypic and phenotypic diversity population structure and genome-wide association study
- Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- Measurement of structural integrity of the spinal cord in patients with amyotrophic lateral sclerosis using diffusion tensor magnetic resonance imaging
- Typological analysis of public-private partnerships in the veterinary domain
- Improved clinical outcome after medial open-wedge osteotomy despite cartilage lesions in the lateral compartment
- Rapid and structure-specific cellular uptake of selected steroids
- Avoiding gambling harm: An evidence-based set of safe gambling practices for consumers
- Epidemiology of chronic pain in Ukraine: Findings from the World Mental Health Survey
- PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target
- Double triage to identify poorly annotated genes in maize: The missing link in community curation
- N-acetyl cysteine restores the fertility of vitrified–warmed mouse oocytes derived through ultrasuperovulation
- Architecture of population-differentiated polymorphisms in the human genome
- Linguistic neutrosophic power Muirhead mean operators for safety evaluation of mines
- Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes
- Exercise intensity-dependent effects of arm and leg-cycling on cognitive performance
- How information about perpetrators’ nature and nurture influences assessments of their character, mental states, and deserved punishment
- Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis
- In silico assessment of human Calprotectin subunits (S100A8/A9) in presence of sodium and calcium ions using Molecular Dynamics simulation approach
- Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging
- Measurable residual disease monitoring for patients with acute myeloid leukemia following hematopoietic cell transplantation using error corrected hybrid capture next generation sequencing
- Characteristics of complementary medicine therapists in Switzerland: A cross-sectional study
- Lack of generalization between explicit and implicit visuomotor learning
- Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population
- Effects of temperature and salinity on respiratory losses and the ratio of photosynthesis to respiration in representative Antarctic phytoplankton species
- Self-reported non-receipt of HIV test results: A silent barrier to HIV epidemic control in Mozambique
- Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature
- Echocardiography overestimates LV mass in the elderly as compared to cardiac CT
- Efficacy of cotrimoxazole (Sulfamethoxazole-Trimethoprim) as a salvage therapy for the treatment of bone and joint infections (BJIs)
- Molecular mechanism of antimicrobial activity of chlorhexidine against carbapenem-resistant Acinetobacter baumannii
- First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides
- Green synthesis of silver nanoparticles using Solanum mammosum L. (Solanaceae) fruit extract and their larvicidal activity against Aedes aegypti L. (Diptera: Culicidae)
- Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007
- Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
- 13C and 15N NMR identification of product compound classes from aqueous and solid phase photodegradation of 2,4,6-trinitrotoluene
- Off-target effects of CRISPRa on interleukin-6 expression
- Exploring the antimicrobial properties of dark-operating ceramic-based nanocomposite materials for the disinfection of indoor air
- Experienced males recognise and avoid mating with non-virgin females in the western flower thrips
- Liver transplantation in patients with a history of migration—A German single center comparative analysis
- Retraction: The Different Role of Notch1 and Notch2 in Astrocytic Gliomas
- Correction: Understanding climate change from a global analysis of city analogues
- Comparison of 4D Flow MRI to 2D Flow MRI in the pulmonary arteries in healthy volunteers and patients with pulmonary hypertension
- The relationship between sleep quality, inappropriate medication use and frailty among older adults in aged care homes in Malaysia
- Clonal diversity and spatial genetic structure in the long-lived herb, Prairie trillium
- Medication histories documentation at the community pharmacy setting: A study from Jordan
- Population dynamics of an invasive bird parasite, Philornis downsi (Diptera: Muscidae), in the Galapagos Islands
- Because you had a bad day: General and daily relations between reactive temperament, emotion regulation, and depressive symptoms in youth
- Socioeconomic status and alcohol use disorders across the lifespan: A co-relative control study
- Generation of deletions and precise point mutations in Dictyostelium discoideum using the CRISPR nickase
- Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation
- Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study
- Validation and perception of a key feature problem examination in neurology
- Gender affirmative HIV care framework: Decisions on feminizing hormone therapy (FHT) and antiretroviral therapy (ART) among transgender women
- Quantifying international human mobility patterns using Facebook Network data
- Localization and characterization of thyroid microcalcifications: A histopathological study
- Young children are the main victims of fast food induced obesity in Brazil
- Understanding self-reported importance of religion/spirituality in a North American sample of individuals at risk for familial depression: A principal component analysis
- Standing balance of professional ballet dancers and non-dancers under different conditions
- 30-day unplanned readmission rate in otolaryngology patients: A population-based study in Thuringia, Germany
- Physical exercise stimulates salivary secretion of cystatins
- Vintage electronics for trusted radiation measurements and verified dismantlement of nuclear weapons
- Keepin’ it real: Linguistic models of authenticity judgments for artificially generated rap lyrics
- Carbon emission reduction and profit distribution mechanism of construction supply chain with fairness concern and cap-and-trade
- Modulations of microbehaviour by associative memory strength in Drosophila larvae
- Changes in peak expiratory flow rates using two head-tilt/chin-lift maneuver angles in young healthy conscious volunteers
- 3D image analysis reveals differences of CD30 positive cells and network formation in reactive and malignant human lymphoid tissue (classical Hodgkin Lymphoma)
- Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- 2-methylquinazoline derivative F7 as a potent and selective HDAC6 inhibitor protected against rhabdomyolysis-induced acute kidney injury
- Correction: Reducing growth and developmental problems in children: Development of an innovative postnatal risk assessment
- Comparative analysis of the vertebral pneumatization in pterosaurs (Reptilia: Pterosauria) and extant birds (Avialae: Neornithes)
- Associations between cognitive performance and sigma power during sleep in children with attention-deficit/hyperactivity disorder, healthy children, and healthy adults
- Retraction: MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1
- Comparing growth patterns of three species: Similarities and differences
- Iron is increased in the brains of ageing mice lacking the neurofilament light gene
- Economic evaluation of community acquired pneumonia management strategies: A systematic review of literature
- A participatory community case study of periurban coastal flood vulnerability in southern Ecuador
- Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL
- Mitochondrial dysfunctions in leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL)
- MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex
- Knowledge, attitudes, and practices related to anthrax and animal care: A case-control study in Georgia
- Information diffusion in signed networks
- Nurses’ perspectives on their communication with patients in busy oncology wards: A qualitative study
- Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS
- ART is key to clearing oncogenic HPV genotypes (HR-HPV) in anal mucosa of HIV-positive MSM
- Retraction: Fluid–Structure Interaction-Based Biomechanical Perception Model for Tactile Sensing
- Correction: Role of Caveolin-1 in Atrial Fibrillation as an Anti-Fibrotic Signaling Molecule in Human Atrial Fibroblasts
- The French adaptation and validation of the Partners in Health (PIH) scale among patients with chronic conditions seen in primary care
- Depth inversion with a 3D structure influences brightness perception
- Analysis of group evolution prediction in complex networks
- Effect of aridity and dune type on rhizosphere soil bacterial communities of Caragana microphylla in desert regions of northern China
- Knowledge, attitudes, and practices related to TB among the general population of Ethiopia: Findings from a national cross-sectional survey
- Correction: Personality traits in companion dogs—Results from the VIDOPET
- MANET 3.0: Hierarchy and modularity in evolving metabolic networks
- Agreement study on gait assessment using a video-assisted rating method in patients with idiopathic normal-pressure hydrocephalus
- Single fixed low-dose rituximab as induction therapy suppresses de novo donor-specific anti-HLA antibody production in ABO compatible living kidney transplant recipients
- Myomesin is part of an integrity pathway that responds to sarcomere damage and disease
- Acute normobaric hypoxia does not affect the simultaneous exercise-induced increase in circulating BDNF and GDNF in young healthy men: A feasibility study
- Systematic investigation on quad-metallic AgAuPdPt and tri-metallic AuPdPt NPs through the solid-state dewetting of quad-layer Ag/Au/Pd/Pt thin films on c-plane sapphire
- Video lecturing in Clicker-assisted English flipped class
- Significant changes of the choroid in patients with ocular ischemic syndrome and symptomatic carotid artery stenosis
- Skewed T cell responses to Epstein-Barr virus in long-term asymptomatic kidney transplant recipients
- Candidate genes expression profiling during wilting in chickpea caused by Fusarium oxysporum f. sp. ciceris race 5
- Host plants influence the composition of the gut bacteria in Henosepilachna vigintioctopunctata
- ‘We are all serving the same Ugandans’: A nationwide mixed-methods evaluation of private sector surgical capacity in Uganda
- The association between flavor capsule cigarette use and sociodemographic variables: Evidence from Chile
- Relations between gross motor skills and executive functions, controlling for the role of information processing and lapses of attention in 8-10 year old children
- Linalool acts as a fast and reversible anesthetic in Hydra
- Double burden of maternal and child malnutrition and socioeconomic status in urban Sri Lanka
- Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles
- Adherence to general medical checkup and cancer screening guidelines according to self-reported smoking status: Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2012
- Do older English adults exhibit day-to-day compensation in sedentary time and in prolonged sedentary bouts? An EPIC-Norfolk cohort analysis
- Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue
- Correction: Factors associated with hospitalization and death among TB/HIV co-infected persons in Porto Alegre, Brazil
- An ex vivo tissue model of cartilage degradation suggests that cartilage state can be determined from secreted key protein patterns
- Reporting adverse events related to medical devices: A single center experience from a tertiary academic hospital
- Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism
- Estimating biodiversity changes in the Camargue wetlands: An expert knowledge approach
- Decreased risk of Parkinson’s disease in diabetic patients with thiazolidinediones therapy: An exploratory meta-analysis
- Retraction: Carboxyamidotriazole-Orotate Inhibits the Growth of Imatinib-Resistant Chronic Myeloid Leukaemia Cells and Modulates Exosomes-Stimulated Angiogenesis
- Lipoarabinomannan from Mycobacterium indicus pranii shows immunostimulatory activity and induces autophagy in macrophages
- A measure of inconsistencies in intertemporal choice
- A novel radiopaque tissue marker for soft tissue localization and in vivo length and area measurements
- Anatomical, histological and computed tomography comparisons of the eye and adnexa of crab-eating fox (Cerdocyon thous) to domestic dogs
- Subpopulation augmentation among habitat patches as a tool to manage an endangered Mojave Desert wetlands-dependent rodent during anthropogenic restricted water climate regimes
- Characteristics of CD5-positive diffuse large B-cell lymphoma among Koreans: High incidence of BCL2 and MYC double-expressors
- Fossil tabulate corals reveal outcrops of Paleozoic sandstones in the Atlantic Coastal Plain Province, Southeastern USA
- Coming and going – Historical distributions of the European oyster Ostrea edulis Linnaeus, 1758 and the introduced slipper limpet Crepidula fornicata Linnaeus, 1758 in the North Sea
- Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter
- Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation
- Can emotional intelligence be improved? A randomized experimental study of a business-oriented EI training program for senior managers
- Genetic variability in landraces populations and the risk to lose genetic variation. The example of landrace ‘Kyperounda’ and its implications for ex situ conservation
- Sleep problems are a strong predictor of stress-related metabolic changes in police officers. A prospective study
- Age, sex and primary care setting differences in patients’ perception of community healthcare seeking behaviour towards health services
- Kinematic analyses including finite helical axes of drop jump landings demonstrate decreased knee control long after anterior cruciate ligament injury
- Effects of model inaccuracies on reaching movements with intermittent control
- C-reactive protein to albumin ratio predicts the outcome in renal cell carcinoma: A meta-analysis
- A new synthetic lure for management of the invasive giant African snail, Lissachatina fulica
- Bridging solvent molecules mediate RNase A – Ligand binding
- Variation in methods, results and reporting in electronic health record-based studies evaluating routine care in gout: A systematic review
- The use of prophylactic intra-aortic balloon pump in high-risk patients undergoing coronary artery bypass grafting
- Compliance with clinical guidelines for breast cancer management: A population-based study of quality-of-care indicators in France
- Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis
- Acute effects of differential learning on football kicking performance and in countermovement jump
- Escherichia coli and Salmonella spp. isolated from Australian meat chickens remain susceptible to critically important antimicrobial agents
- Play like me: Similarity in playfulness promotes social play
- Awareness of family health history in a predominantly young adult population
- Care pathways during a child’s final illness in rural South Africa: Findings from a social autopsy study
- Intranasal lidocaine for acute migraine: A meta-analysis of randomized controlled trials
- Evaluating case management as a complex intervention: Lessons for the future
- Allele-specific enhancer interaction at the Peg3 imprinted domain
- Has the “M” word been framed? Marijuana, cannabis, and public opinion
- Is spontaneous normalization of systolic blood pressure within 24 hours after ischemic stroke onset related with favorable outcomes?
- Mixotrophic cultivation of Spirulina platensis in dairy wastewater: Effects on the production of biomass, biochemical composition and antioxidant capacity
- Constitutive expression of an A-5 subgroup member in the DREB transcription factor subfamily from Ammopiptanthus mongolicus enhanced abiotic stress tolerance and anthocyanin accumulation in transgenic Arabidopsis
- Stable carbon isotope diagnostics of mammalian metabolism, a high-resolution isotomics approach using amino acid carboxyl groups
- Factors associated with depressive symptoms in patients with ankylosing spondylitis in Northern Taiwan
- A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
- Retraction: Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1
- Potential role for microRNA-16 (miR-16) and microRNA-93 (miR-93) in diagnosis and prediction of disease progression in mycosis fungoides in Egyptian patients
- Rapid visual categorization is not guided by early salience-based selection
- Relative contribution of climate and non-climate drivers in determining dynamic rates of boreal birds at the edge of their range
- A simple-to-use nomogram to predict long term survival of patients undergoing coronary artery bypass grafting (CABG) using bilateral internal thoracic artery grafting technique
- Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model
- Antenatal and intrapartum interventions for reducing caesarean section, promoting vaginal birth, and reducing fear of childbirth: An overview of systematic reviews
- Relative species abundance successfully predicts nestedness and interaction frequency of monthly pollination networks in an alpine meadow
- Correction: RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
- Amphibians on the hotspot: Molecular biology and conservation in the South American Atlantic Rainforest
- Role of psychosocial status in predicting health-related quality of life at 1-year follow-up among newly diagnosed people living with HIV
- Application of national pollutant inventories for monitoring trends on dioxin emissions from stationary industrial sources in Australia, Canada and European Union
- The association between vaccination confidence, vaccination behavior, and willingness to recommend vaccines among Finnish healthcare workers
- Retraction: Interleukin-1β-Induced Autophagy-Related Gene 5 Regulates Proliferation of Embryonic Stem Cell-Derived Odontoblastic Cells
- A localized sanitation status index as a proxy for fecal contamination in urban Maputo, Mozambique
- E2 protein is the major determinant of specificity at the human papillomavirus origin of replication
- “You’re kind of at war with yourself as a nurse”: Perspectives of inpatient nurses on treating people who present with a comorbid opioid use disorder
- A refinement approach in a mouse model of rehabilitation research. Analgesia strategy, reduction approach and infrared thermography in spinal cord injury
- Circulating cell-free DNA from plasma undergoes less fragmentation during bisulfite treatment than genomic DNA due to low molecular weight
- Understanding fatigue in adults with visual impairment: A path analysis study of sociodemographic, psychological and health-related factors
- Retraction: Mouse-Induced Pluripotent Stem Cells Differentiate into Odontoblast-Like Cells with Induction of Altered Adhesive and Migratory Phenotype of Integrin
- A novel analytical method to assess the effect of imipenem/cilastatin on liver function laboratory indexes in Chinese underage inpatients: Probability distribution curve
- The cause of anorexia and proportion of its recovery in older adults without underlying disease: Results of a retrospective study
- Referral and admission to intensive care: A qualitative study of doctors’ practices in a Tanzanian university hospital
- Agreement between clinical and non-clinical digital manometer for assessing maximal respiratory pressures in healthy subjects
- Heads or tails? Differential translational regulation in cercarial heads and tails of schistosome worms
- Horizontal seed dispersal by dung beetles reduced seed and seedling clumping, but did not increase short-term seedling establishment
- The coupling of the M2 muscarinic receptor to its G protein is voltage dependent
- Subsidy strategy of pharmaceutical e-commerce platform based on two-sided market theory
- Shoulder girdle injuries involving the medial clavicle differ from lateral clavicle injuries with a focus on concomitant injuries and management strategies: A retrospective study based on nationwide routine data
- Unraveling middle childhood attachment-related behavior sequences using a micro-coding approach
- Divergence history and hydrothermal vent adaptation of decapod crustaceans: A mitogenomic perspective
- Duration of solid fuel cookstove use is associated with increased risk of acute lower respiratory infection among children under six months in rural central India
- Evolving flocking in embodied agents based on local and global application of Reynolds’ rules
- Non-invasive contrast enhanced ultrasound molecular imaging of inflammation in autoimmune myocarditis for prediction of left ventricular fibrosis and remodeling
- Care coordination for chronic and complex health conditions: An experienced based co-design study engaging consumer and clinician groups for service improvement
- Association between socioeconomic status and diet quality in Mexican men and women: A cross-sectional study
- Surveillance of panicle positions by unmanned aerial vehicle to reveal morphological features of rice
- Is Betula carpatica genetically distinctive? A morphometric, cytometric and molecular study of birches in the Bohemian Massif with a focus on Carpathian birch
- Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance
- The genome of the migratory nematode, Radopholus similis, reveals signatures of close association to the sedentary cyst nematodes
- Factors associated with pneumococcal carriage and density in infants and young children in Laos PDR
- Overlap between telangiectasia and photoreceptor loss increases with progression of macular telangiectasia type 2
- The role of hope for health professionals in rehabilitation: A qualitative study on unfavorable prognosis communication
- Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression
- Molecular characterization and In Vitro synthesis of infectious RNA of a Turnip vein-clearing virus isolated from Alliaria petiolata in Hungary
- Assessment of client satisfaction with pharmacist services at outpatient pharmacy of Tikur Anbessa Specialized Hospital
- Thermogravimetric analysis of the co-combustion of coal and polyvinyl chloride
- Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice
- Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
- APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy
- Integrating a gait analysis test in hospital rehabilitation: A service design approach
- Correction: Bioactivity-guided isolation of rosmarinic acid as the principle bioactive compound from the butanol extract of Isodon rugosus against the pea aphid, Acyrthosiphon pisum
- Soil-borne fungi influence seed germination and mortality, with implications for coexistence of desert winter annual plants
- Applying Corrigan’s progressive model of self-stigma to people with depression
- Do psychosocial factors modify the negative association between disability and life satisfaction in old age?
- Public perception of coastal habitat loss and habitat creation using artificial floating islands in the UK
- Transcriptional foliar profile of the C3-CAM bromeliad Guzmania monostachia
- Application of tuned liquid column ball damper (TLCBD) for improved vibration control performance of multi-storey structure
- Do protection gradients explain patterns in herbivore densities? An example with ungulates in Zambia’s Luangwa Valley
- Consequences of chronic bacterial infection in Drosophila melanogaster
- The effects of environmental parameters on the microbial activity in peat-bog lakes
- Differences in protein structural regions that impact functional specificity in GT2 family β-glucan synthases
- Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan
- Changes of absorbed dose rate in air in metropolitan Tokyo relating to radiocesium released from the Fukushima Daiichi Nuclear Power Plant accident: Results of a five-year study
- Histological chorioamnionitis, antenatal steroids, and neonatal outcomes in very low birth weight infants: A nationwide study
- A machine learning approach for the prediction of pulmonary hypertension
- Altered microbiota, fecal lactate, and fecal bile acids in dogs with gastrointestinal disease
- Impaired processing of threat in psychopathy: A systematic review and meta-analysis of factorial data in male offender populations
- Dimethyl disulfide (DMDS) as an effective soil fumigant against nematodes in China
- Risk factors for hepatitis C infection among adult patients in Kedah state, Malaysia: A case–control study
- Factoring a 2 x 2 contingency table
- The development of connectives in three to five-year-old monolingual Spanish-speaking children
- Foliar plasticity related to gradients of heat and drought stress across crown orientations in three Mediterranean Quercus species
- The evolution of haploid chromosome numbers in Meliponini
- Bloodstream infections caused by Escherichia coli in onco-haematological patients: Risk factors and mortality in an Italian prospective survey
- Facial features and unethical behavior – Doped athletes show higher facial width-to-height ratios than non-doping sanctioned athletes
- Non-resolution of non-alcoholic fatty liver disease (NAFLD) among urban, adult Sri Lankans in the general population: A prospective, cohort follow-up study
- Left ventricular simulation of cardiac compression: Hemodynamics and regional mechanics
- Are we ready for scaling up restoration actions? An insight from Mediterranean macroalgal canopies
- Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina)
- Parasitism modifies the direct effects of warming on a hemiparasite and its host
- Analytic performance of PANArray HPV and HPV 9G DNA chip tests for genotyping of high-risk human papillomavirus in cervical ThinPrep PreservCyt samples
- Transcript profile of skeletal muscle lipid metabolism genes affected by diet in a piglet model of low birth weight
- Differential impact of smoking on cardiac or non-cardiac death according to age
- Influence of injectate volume on paravertebral spread in erector spinae plane block: An endoscopic and anatomical evaluation
- Correction: Nitrogen starvation induces distinct photosynthetic responses and recovery dynamics in diatoms and prasinophytes
- Healthcare needs and programmatic gaps in transition from pediatric to adult care of vertically transmitted HIV infected adolescents in India
- Retraction: Neuronal Differentiation Dictates Estrogen-Dependent Survival and ERK1/2 Kinetic by Means of Caveolin-1
- Correction: Disability and its association with sociodemographic factors among elderly persons residing in an urban resettlement colony, New Delhi, India
- Antibacterial activity of varying UMF-graded Manuka honeys
- Correction: Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli
- Detection and genetic characterization of Echinococcus granulosus mitochondrial DNA in serum and formalin-fixed paraffin embedded cyst tissue samples of cystic echinococcosis patients
- Deep-learning-based risk stratification for mortality of patients with acute myocardial infarction
- Links between meaning in life and physical quality of life after rehabilitation: Mediating effects of positive experiences with physical exercises and mobility
- The estrogen effect; clinical and histopathological evidence of dichotomous influences in dogs with spontaneous mammary carcinomas
- The association between socioeconomic status, psychopathological symptom burden in mothers, and early childhood caries of their children
- Increased rate of FEV1 decline in HIV patients despite effective treatment with HAART
- Parallels between stream and coastal water quality associated with groundwater discharge
- Determinants of anemia among pregnant women attending antenatal care in Horo Guduru Wollega Zone, West Ethiopia: Unmatched case-control study
- Depression and anxiety among pregnant women living with HIV in Kilimanjaro region, Tanzania
- Shift in trophic niches of soil microarthropods with conversion of tropical rainforest into plantations as indicated by stable isotopes (15N, 13C)
- On the development of sleep states in the first weeks of life
- CCR5 receptor antagonism inhibits hepatitis C virus (HCV) replication in vitro
- Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise
- Correction: Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts
- MitoToxy assay: A novel cell-based method for the assessment of metabolic toxicity in a multiwell plate format using a lactate FRET nanosensor, Laconic
- Correction: Evidence for plant-derived xenomiRs based on a large-scale analysis of public small RNA sequencing data from human samples
- Correction: Prognostic impact of systolic blood pressure variability in people with diabetes
- Retraction: Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis
- Too much? Mortality and health service utilisation among Danish children 1999-2016: A register-based study
- Effects of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors on diabetic retinopathy and its progression: A real-world Korean study
- Shipworm bioerosion of lithic substrates in a freshwater setting, Abatan River, Philippines: Ichnologic, paleoenvironmental and biogeomorphical implications
- Genetic codes optimized as a traveling salesman problem
- Effect of antenatal detection of small-for-gestational-age newborns in a risk stratified retrospective cohort
- Using family network data in child protection services
- Transcriptome sequencing reveals the effect of biochar improvement on the development of tobacco plants before and after topping
- Volatile anesthetics versus total intravenous anesthesia in patients undergoing coronary artery bypass grafting: An updated meta-analysis and trial sequential analysis of randomized controlled trials
- Cumulative fluid balance predicts mortality and increases time on mechanical ventilation in ARDS patients: An observational cohort study
- Stated-preference research in HIV: A scoping review
- Correction: Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
- Antinociceptive compounds and LC-DAD-ESIMSn profile from Dictyoloma vandellianum leaves
- Time series experimental design under one-shot sampling: The importance of condition diversity
- Evaluation of protocols for rRNA depletion-based RNA sequencing of nanogram inputs of mammalian total RNA
- Prevalence and predictors of primary postpartum hemorrhage: An implication for designing effective intervention at selected hospitals, Southern Ethiopia
- Correction: Stillbirths in urban Guinea-Bissau: A hospital- and community-based study
- Correction: Method for spike detection from microelectrode array recordings contaminated by artifacts of simultaneous two-photon imaging
- Correction: Peripheral blood mononuclear cells extracts VEGF protein levels and VEGF mRNA: Associations with inflammatory molecules in a healthy population
- Correction: Novel site-specific PEGylated L-asparaginase
- Effect of caffeine ingestion on competitive rifle shooting performance
- Correction: Color adaptation induced from linguistic description of color
- MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity
- Correction: A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Correction: A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated extracellular vesicle enrichment by acoustic trapping to microRNA sequencing
- Measurement of horizontal ocular deviation on magnetic resonance imaging in various disease with acute vertigo
- Clinical outcomes of early gastric cancer with non-curative resection after pathological evaluation based on the expanded criteria
- Detection of quantitative trait loci associated with drought tolerance in St. Augustinegrass
- An examination of the Kuleshov effect using still photographs
- Correction: Relationship between non-communicable diseases and background characteristics among homeless people in Nagoya City, Japan
- An exploration of automated narrative analysis via machine learning
- Correction: Frozen by stress: Stress increases scope insensitivity
- The pragmatic role of trust in young children’s interpretation of unfamiliar signals
- Measuring egocentric distance perception in virtual reality: Influence of methodologies, locomotion and translation gains
- Mathematical modeling of cardiac function to evaluate clinical cases in adults and children
- Correction: Forecasting the impact of population ageing on tuberculosis incidence
- “The car is my extra legs” – Experiences of outdoor mobility amongst immigrants in Sweden with late effects of polio
- Correction: Multilevel analyses of on-demand medication data, with an application to the treatment of Female Sexual Interest/Arousal Disorder
- Correction: The world’s user-generated road map is more than 80% complete
- Correction: Predictors of opioid efficacy in patients with chronic pain: A prospective multicenter observational cohort study
- Correction: Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Correction: Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases
- Correction: Effect of early measles vaccine on pneumococcal colonization: A randomized trial from Guinea-Bissau
- Correction: Tuberculosis patients in an Indian mega-city: Where do they live and where are they diagnosed?
- Correction: Priority Queue Based Reactive Buffer Management Policy for Delay Tolerant Network under City Based Environments
- Correction: Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma
- Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
- Correction: Evolution and study of a copycat effect in intimate partner homicides: A lesson from Spanish femicides
- Correction: Transforming growth factor beta 1 induces methylation changes in lung fibroblasts
- Correction: Congenital Zika Syndrome in a Brazil-Paraguay-Bolivia border region: Clinical features of cases diagnosed between 2015 and 2018
- Correction: Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression
- Correction: Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance
- Correction: Nonalcoholic fatty liver disease is a risk factor for large-for-gestational-age birthweight
- Retraction: Butyrate Attenuates Lipopolysaccharide-Induced Inflammation in Intestinal Cells and Crohn's Mucosa through Modulation of Antioxidant Defense Machinery
- Retraction: Tetrandrine Suppresses Lipopolysaccharide-Induced Microglial Activation by Inhibiting NF-κB and ERK Signaling Pathways in BV2 Cells
- Correction: Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient
- Correction: Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents
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- Prevalence of pectus excavatum (PE), pectus carinatum (PC), tracheal hypoplasia, thoracic spine deformities and lateral heart displacement in thoracic radiographs of screw-tailed brachycephalic dogs
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