Exposure to household pet cats and dogs in childhood and risk of subsequent diagnosis of schizophrenia or bipolar disorder


Autoři: Robert Yolken aff001;  Cassie Stallings aff002;  Andrea Origoni aff002;  Emily Katsafanas aff002;  Kevin Sweeney aff002;  Amalia Squire aff002;  Faith Dickerson aff002
Působiště autorů: Stanley Division of Developmental Neurovirology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America aff001;  Sheppard Pratt Health System, Baltimore, Maryland, United States of America aff002
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225320

Souhrn

Background

Serious psychiatric disorders such as schizophrenia and bipolar disorder have been associated with environmental exposures in early life. Contact with household pets such as cats and dogs can serve as a source of environmental exposure during these time periods.

Methods

We investigated the relationship between exposure to a household pet cat or dog during the first 12 years of life and having a subsequent diagnosis of schizophrenia or bipolar disorder. These studies were performed in a cohort of 396 individuals with schizophrenia, 381 with bipolar disorder, and 594 controls. The hazards of developing schizophrenia or bipolar disorder associated with first exposure to a household pet cat or dog were calculated using Cox Proportional Hazard and multivariate logistic regression models including socio-demographic covariates.

Results

We found that exposure to a household pet dog was associated with a significantly decreased hazard of having a subsequent diagnosis of schizophrenia (Hazard Ratio .75, p < .002) Furthermore, a significant decreased relative risk of schizophrenia was detected following exposure at birth and during the first years of life. There was no significant relationship between household exposure to a pet dog and bipolar disorder. There were no significant associations between exposure to a household pet cat and subsequent risk of either a schizophrenia or bipolar disorder diagnosis. However, there were trends towards an increased risk of both disorders at defined periods of exposure.

Conclusions

Exposure to household pets during infancy and childhood may be associated with altered rates of development of psychiatric disorders in later life.

Klíčová slova:

Age groups – Bipolar disorder – Cats – Diagnostic medicine – Pets and companion animals – Schizophrenia – Socioeconomic aspects of health – Veterinary diagnostics


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Článek vyšel v časopise

PLOS One


2019 Číslo 12