The association between chronic periodontitis and oral Helicobacter pylori: A meta-analysis


Autoři: Xiang Wei aff001;  Hua-Qiang Zhao aff001;  Chuan Ma aff001;  Ao-Bo Zhang aff001;  Hao Feng aff003;  Dong Zhang aff004;  Chao Liu aff004
Působiště autorů: Shandong Province Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, Shandong Province, China aff001;  Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan, Shandong Province, China aff002;  School of Stomatology, West China Hospital of Sichuan University, Chengdu, China aff003;  Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan, China aff004;  Institute of Stomatology, Shandong University, Jinan, China aff005;  Key Laboratory of Otolaryngology, NHFPC (Shandong University), Jinan, China aff006
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225247

Souhrn

Background

Epidemiological studies have shown that gastrointestinal Helicobacter pylori (H. pylori) infection is the main cause of chronic gastritis, but the relation between oral H. pylori and chronic periodontitis (CP) remains uncertain. A meta-analysis of published papers was performed to elucidate the correlation between oral H. pylori and CP.

Method

To perform this meta-analysis, we searched papers published from 2000 to 2018 on PubMed, OVID, Springer Link, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biology Medicine search engines. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the correlation between H. pylori and CP were estimated. Heterogeneity, publication bias and subgroup analyses were also conducted.

Results

A total of 918 papers on oral H. pylori and CP were collected, and 11 papers were in accordance with the inclusion criteria. Oral H. pylori was suggested to be correlated with CP. The results indicated that a H. pylori-positive state significantly increased the risk of CP 3.42 times (OR = 3.42; 95% CI = 2.71–4.31). A diagnostic test using polymerase chain reaction (PCR) showed a higher prevalence of H. pylori (OR = 3.70; 95% CI = 2.66–5.14) than did that using the rapid urease test (RUT) (OR = 3.13; 95% CI = 2.26–4.34).

Conclusions

This paper demonstrated that CP was potentially correlated with oral H. pylori in adults and that oral H. pylori may be a possible risk factor for CP.

Klíčová slova:

Gastritis – Gastrointestinal infections – Helicobacter pylori – Oral diseases – Periodontitis – Polymerase chain reaction – Ureases


Zdroje

1. Tang LQ, Zhong Q, Xu DJ. [A cross-sectional study on periodontal conditions in elderly people in Wuxi city]. Shanghai Kou Qiang Yi Xue. 2010;19(6):568–70. 21431250.

2. Cheng H, Zeng XL, Li CR, Cao SH, Xu W, Feng XP. [The sampling survey of teeth defect and denture restoration among 1579 middle aged and elder people in Shanghai]. Shanghai Kou Qiang Yi Xue. 2009;18(6):561–6. 20143012.

3. Petersen PE, Ogawa H. The global burden of periodontal disease: towards integration with chronic disease prevention and control. Periodontol 2000. 2012;60(1):15–39. doi: 10.1111/j.1600-0757.2011.00425.x 22909104.

4. Loos BG. Systemic effects of periodontitis. Ann R Australas Coll Dent Surg. 2006;18:27–9. 17668587.

5. Zeng XT, Tu ML, Liu DY, Zheng D, Zhang J, Leng W. Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies. PLoS One. 2012;7(10):e46508. doi: 10.1371/journal.pone.0046508 23094025; PubMed Central PMCID: PMC3477163.

6. Kelly JT, Avila-Ortiz G, Allareddy V, Johnson GK, Elangovan S. The association between periodontitis and coronary heart disease: a quality assessment of systematic reviews. J Am Dent Assoc. 2013;144(4):371–9. doi: 10.14219/jada.archive.2013.0130 23543691.

7. Zeng XT, Deng AP, Li C, Xia LY, Niu YM, Leng WD. Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies. PLoS One. 2013;8(10):e79017. doi: 10.1371/journal.pone.0079017 24194957; PubMed Central PMCID: PMC3806857.

8. Wen X, Liu R, Li G, Deng M, Liu L, Zeng XT, et al. History of periodontitis as a risk factor for long-term survival of dental implants: a meta-analysis. Int J Oral Maxillofac Implants. 2014;29(6):1271–80. doi: 10.11607/jomi.3544 25397791.

9. Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol. 2001;6(1):99–112. doi: 10.1902/annals.2001.6.1.99 11887478.

10. Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. Journal of dental research. 2003;82(2):82–90. Epub 2003/02/04. doi: 10.1177/154405910308200202 12562878.

11. Darby I. Periodontal considerations in older individuals. Aust Dent J. 2015;60 Suppl 1:14–9. Epub 2015/03/13. doi: 10.1111/adj.12280 25762038.

12. Hillman JD, Socransky SS, Shivers M. The relationships between streptococcal species and periodontopathic bacteria in human dental plaque. Arch Oral Biol. 1985;30(11–12):791–5. Epub 1985/01/01. doi: 10.1016/0003-9969(85)90133-5 3868968.

13. Hillman JD, Socransky SS. Bacterial interference in the oral ecology of Actinobacillus actinomycetemcomitans and its relationship to human periodontosis. Arch Oral Biol. 1982;27(1):75–7. Epub 1982/01/01. doi: 10.1016/0003-9969(82)90180-7 6951532.

14. Deng ZL, Szafranski SP, Jarek M, Bhuju S, Wagner-Dobler I. Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host. Sci Rep. 2017;7(1):3703. Epub 2017/06/18. doi: 10.1038/s41598-017-03804-8 28623321; PubMed Central PMCID: PMC5473847.

15. He XS, Shi WY. Oral microbiology: past, present and future. Int J Oral Sci. 2009;1(2):47–58. Epub 2009/06/01. doi: 10.4248/ijos.09029 20687296; PubMed Central PMCID: PMC2949409.

16. Blaser MJ. Ecology of Helicobacter pylori in the human stomach. J Clin Invest. 1997;100(4):759–62. doi: 10.1172/JCI119588 9259572; PubMed Central PMCID: PMC508245.

17. Zheng P, Zhou WY. Relation between periodontitis and helicobacter pylori infection. Int J Clin Exp Med. 2015;8(9):16741–4. WOS:000365273300154. 26629215

18. Ruggiero P. Helicobacter pylori and inflammation. Curr Pharm Des. 2010;16(38):4225–36. doi: 10.2174/138161210794519075 21184659.

19. Peach HG, Pearce DC, Farish SJ. Helicobacter pylori infection in an Australian regional city: prevalence and risk factors. Med J Australia. 1997;167(6):310–3. WOS:A1997XY55100008. 9322776

20. Ozdemir A, Mas MR, Sahin S, Saglamkaya U, Ateskan U. Detection of Helicobacter pylori colonization in dental plaques and tongue scrapings of patients with chronic gastritis. Quintessence Int. 2001;32(2):131–4. WOS:000166906600008. 12066673

21. Avcu N, Avcu F, Beyan C, Ural AU, Kaptan K, Ozyurt M, et al. The relationship between gastric-oral Helicobacter pylori and oral hygiene in patients with vitamin B-12-deficiency anemia. Oral Surg Oral Med O. 2001;92(2):166–9. doi: 10.1067/moe.2001.113589 WOS:000170577100010. 11505263

22. Miyabayashi H, Furihata K, Shimizu T, Ueno I, Akamatsu T. Influence of oral Helicobacter pylori on the success of eradication therapy against gastric Helicobacter pylori. Helicobacter. 2000;5(1):30–7. doi: 10.1046/j.1523-5378.2000.00004.x WOS:000085624100005. 10672049

23. Zaric S, Bojic B, Jankovic L, Dapcevic B, Popovic B, Cakic S, et al. Periodontal Therapy Improves Gastric Helicobacter pylori Eradication. Journal of dental research. 2009;88(10):946–50. doi: 10.1177/0022034509344559 WOS:000270286400012. 19783805

24. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100. doi: 10.1371/journal.pmed.1000100 19621070; PubMed Central PMCID: PMC2707010.

25. Agarwal S, Jithendra KD. Presence of Helicobacter pylori in subgingival plaque of periodontitis patients with and without dyspepsia, detected by polymerase chain reaction and culture. J Indian Soc Periodontol. 2012;16(3):398–403. Epub 2012/11/20. doi: 10.4103/0972-124X.100919 23162336; PubMed Central PMCID: PMC3498711.

26. McNutt LA, Wu C, Xue X, Hafner JP. Estimating the relative risk in cohort studies and clinical trials of common outcomes. Am J Epidemiol. 2003;157(10):940–3. doi: 10.1093/aje/kwg074 12746247.

27. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60. doi: 10.1136/bmj.327.7414.557 12958120; PubMed Central PMCID: PMC192859.

28. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34. doi: 10.1136/bmj.315.7109.629 9310563; PubMed Central PMCID: PMC2127453.

29. Zheng P, Zhou W. Relation between periodontitis and helicobacter pylori infection. Int J Clin Exp Med. 2015;8(9):16741–4. Epub 2015/12/03. 26629215; PubMed Central PMCID: PMC4659103.

30. Yang J, Zhang Q, Chen M, Wu WZ, Wang R, Liu CJ, et al. Association Between Helicobacter pylori Infection and Risk of Periodontal Diseases in Han Chinese: A Case-Control Study. Med Sci Monit. 2016;22:121–6. Epub 2016/01/13. doi: 10.12659/MSM.894583 26753766; PubMed Central PMCID: PMC4716709.

31. Souto R, Colombo AP. Detection of Helicobacter pylori by polymerase chain reaction in the subgingival biofilm and saliva of non-dyspeptic periodontal patients. J Periodontol. 2008;79(1):97–103. Epub 2008/01/02. doi: 10.1902/jop.2008.070241 18166098.

32. Al-Refai AN, Fathalla SE, Nagamani R, Al-Momen S. Incidence of helicobacter pylori in dental plaque of saudi gastritis patients. J Family Community Med. 2002;9(2):27–36. Epub 2002/05/01. 23008669; PubMed Central PMCID: PMC3430182.

33. Al Asqah M, Al Hamoudi N, Anil S, Al Jebreen A, Al-Hamoudi WK. Is the presence of Helicobacter pylori in dental plaque of patients with chronic periodontitis a risk factor for gastric infection? Can J Gastroenterol. 2009;23(3):177–9. Epub 2009/03/26. doi: 10.1155/2009/950527 19319381; PubMed Central PMCID: PMC2694652.

34. Miao WJ, Z; Lei Z; Guang C. The clinical study on the effects of chronic periodontitis and periodontal initial therapy for the infection and eradication of Helicobacter pylori. Chinese Journal of Gerontology. 2015;35(20):5886–7.

35. Gong L-X. The research of relationship between periodontitis and helicobacter pylori. J coal industry. 2011;14(4):625–7.

36. Jing LJ, S. Association Between Helicobacter pylori Infection and Risk of Periodontal Diseases in Han non-smoking Chinese. J dent research. 2015;31(12):1251–3.

37. Li W. The significance of detection Helicobacter pylori in the tissue of chronic periodontitis utilizing PCR technique. J Henan Medical College for Staff and Workers. 2001;13(3):0248–02.

38. Jing GS, Z; Xian L; Yue L; Yan W. Correlativity of the chronic periodontitis with helicobacter pylori infection. J Clin Stomatol. 2011;27(1):5–7.

39. Ying JH, X; Xin G; Yong Z. Effect of oral environmental changes on Helicobacter pylori in patients with periodontitis. Med Zhejiang. 2002;24(5):274–6.

40. Adler I, Muino A, Aguas S, Harada L, Diaz M, Lence A, et al. Helicobacter pylori and oral pathology: relationship with the gastric infection. World J Gastroenterol. 2014;20(29):9922–35. doi: 10.3748/wjg.v20.i29.9922 25110422; PubMed Central PMCID: PMC4123373.

41. Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G. Diagnosis of Helicobacter pylori: what should be the gold standard? World J Gastroenterol. 2014;20(36):12847–59. Epub 2014/10/04. doi: 10.3748/wjg.v20.i36.12847 25278682; PubMed Central PMCID: PMC4177467.

42. Butt AK, Khan AA, Suleman BA, Bedi R. Randomized clinical trial of Helicobacter pylori from dental plaque. The British journal of surgery. 2001;88(2):206. Epub 2001/02/13. doi: 10.1046/j.1365-2168.2001.01684.x 11167867.

43. Gurbuz AK, Ozel AM, Yazgan Y, Celik M, Yildirim S. Oral colonization of Helicobacter pylori: risk factors and response to eradication therapy. Southern medical journal. 2003;96(3):244–7. Epub 2003/03/28. doi: 10.1097/01.SMJ.0000051069.50950.2B 12659355.

44. Gebara EC, Faria CM, Pannuti C, Chehter L, Mayer MP, Lima LA. Persistence of Helicobacter pylori in the oral cavity after systemic eradication therapy. Journal of clinical periodontology. 2006;33(5):329–33. Epub 2006/04/26. doi: 10.1111/j.1600-051X.2006.00915.x 16634953.

45. Anand PS, Kamath KP, Anil S. Role of dental plaque, saliva and periodontal disease in Helicobacter pylori infection. World J Gastroenterol. 2014;20(19):5639–53. doi: 10.3748/wjg.v20.i19.5639 24914323; PubMed Central PMCID: PMC4024772.

46. Yan Y, Weng H, Shen ZH, Wu L, Zeng XT. Association between interleukin-4 gene -590 c/t, -33 c/t, and 70-base-pair polymorphisms and periodontitis susceptibility: a meta-analysis. J Periodontol. 2014;85(11):e354–62. doi: 10.1902/jop.2014.140317 25029213.

47. Jiang L, Weng H, Chen MY, Zhang C, Zeng XT. Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals. Mol Biol Rep. 2014;41(7):4795–801. doi: 10.1007/s11033-014-3350-z 24695999.

48. Albandar JM. Epidemiology and risk factors of periodontal diseases. Dent Clin North Am. 2005;49(3):517–32, v-vi. doi: 10.1016/j.cden.2005.03.003 15978239.

49. Dye BA, Kruszon-Moran D, McQuillan G. The relationship between periodontal disease attributes and Helicobacter pylori infection among adults in the United States. Am J Public Health. 2002;92(11):1809–15. doi: 10.2105/ajph.92.11.1809 12406813; PubMed Central PMCID: PMC1447333.

50. Skrebinska S, Megraud F, Bessede E. Diagnosis of Helicobacter pylori infection. Helicobacter. 2018;23 Suppl 1:e12515. Epub 2018/09/12. doi: 10.1111/hel.12515 30203584.


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