Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population


Autoři: María Guadalupe Salas-Martínez aff001;  Yolanda Saldaña-Alvarez aff001;  Emilio J. Cordova aff001;  Diana Karen Mendiola-Soto aff001;  Miguel A. Cid-Soto aff001;  Angélica Luckie-Duque aff003;  Hermenegildo Vicenteño-Ayala aff004;  Francisco Barajas-Olmos aff001;  Cecilia Contreras-Cubas aff001;  Humberto García-Ortiz aff001;  Juan L. Jiménez-Ruíz aff001;  Federico Centeno-Cruz aff001;  Angélica Martínez-Hernández aff001;  Elvia C. Mendoza-Caamal aff005;  Elaheh Mirzaeicheshmeh aff001;  Lorena Orozco aff001
Působiště autorů: Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City, Mexico aff001;  Genomic Sciences Program, Universidad Autónoma de la Ciudad de México, Mexico City, Mexico aff002;  Hospital Regional 1° de Octubre, ISSSTE, Mexico City, Mexico aff003;  Hospital Regional Adolfo López Mateos, ISSSTE, Mexico City, Mexico aff004;  Clinical Area, Instituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City, Mexico aff005
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225030

Souhrn

The Mexican population is characterized by high and particular admixture, and the picture of variants associated with disease remains unclear. Here we investigated the distribution of single nucleotide polymorphisms (SNPs) in the Mexican population. We focused on two non-synonymous and three synonymous SNPs in the beta-2 adrenergic receptor gene (ADRB2), which plays key roles in energy balance regulation. These SNPs were genotyped in 2,011 Mexican Amerindians (MAs) belonging to 62 ethnic groups and in 1,980 geographically matched Mexican Mestizos (MEZs). The frequency distribution of all five ADRB2 variants significantly differed between MAs, MEZs, and other continental populations (CPs) from the 1000 Genomes database. Allele frequencies of the three synonymous SNPs rs1042717A, rs1042718A, and rs1042719C were significantly higher in Mexican individuals, particularly among MAs, compared to in the other analyzed populations (P<0.05). The non-synonymous ADRB2 Glu27 allele (rs1042714G), which is associated with several common conditions, showed the lowest frequency in MAs (0.03) compared to other populations worldwide. Among MEZs, this allele showed a frequency of 0.15, intermediate between that in MAs and in Iberians (0.43). Moreover, Glu27 was the only SNP exhibiting a geographic gradient within the MEZ population (from 0.22 to 0.11), reflecting admixed mestizo ancestry across the country. Population differentiation analysis demonstrated that Glu27 had the highest FST value in MAs compared with Europeans (CEU) (0.71), and the lowest between MAs and Japanese (JPT) (0.01), even lower than that observed between MAs and MEZs (0.08). This analysis demonstrated the genetic diversity among Amerindian ethnicities, with the most extreme FST value (0.34) found between the Nahuatls from Morelos and the Seris. This is the first study of ADRB2 genetic variants among MA ethnicities. Our findings add to our understanding of the genetic contribution to variability in disease susceptibility in admixed populations.

Klíčová slova:

Alleles – Genetics of disease – Geographic distribution – Haplotypes – Mexican people – Phylogeography – Population genetics – Variant genotypes


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