Utility of preoperative electrophysiological testing of the facial nerve in patients with vestibular schwannoma


Autoři: Przemysław Kunert aff001;  Anna Podgórska aff001;  Tomasz Andrzej Dziedzic aff001;  Andrzej Marchel aff001
Působiště autorů: Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland aff001
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226607

Souhrn

Purpose

The aim of this study was to analyze the utility of various preoperative electrophysiological tests of the facial nerve CNVII in predicting CNVII function after vestibular schwannoma surgery.

Methods

This retrospective study included 176 patients who had preoperative facial nerve electroneurography and electrically evoked blink reflex testing. We defined the following variables: axonal degeneration of CNVII (AD-CNVII), trigeminal nerve damage (D-CNV), disturbances in the short-latency pathway of the blink reflex (D-BR), and any changes in electrophysiological test results (A-EMG).

Results

AD-CNVII, D-CNV, D-BR, and A-EMG were noted in 24%, 10%, 64%, and 71% of the patients, respectively. Negative D-CNV correlated with good CNVII function in early (p = 0.005) and long-term follow-up (p = 0.003) but was not an independent prognostic factor for postoperative facial muscles function. D-CNV appeared to be closely related to tumor size. D-BR was related to tumor size and had no predictive value. AD-CNVII (amplitude reduction of 50% or more compared to the healthy side) was an independent factor associated with increased risk of facial muscles weakness (p = 0.015 and p = 0.031 for early and late outcomes, respectively).

Conclusions

Further studies are needed to establish which tests and cut-off values are the most useful for predicting post-surgical facial nerve function.

Klíčová slova:

Electrophysiology – Face – Facial nerve – Muscle electrophysiology – Neurophysiology – Reflexes – Surgical and invasive medical procedures – Surgical oncology


Zdroje

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2019 Číslo 12