In vivo ultrasound thermal ablation control using echo decorrelation imaging in rabbit liver and VX2 tumor

Autoři: Mohamed A. Abbass aff001;  Syed A. Ahmad aff002;  Neeraja Mahalingam aff001;  K. Sameer Krothapalli aff001;  Jack A. Masterson aff001;  Marepalli B. Rao aff001;  Peter G. Barthe aff004;  T. Douglas Mast aff001
Působiště autorů: Dept of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, United States of America aff001;  Dept of Surgery, University of Cincinnati, Cincinnati, Ohio, United States of America aff002;  Dept of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America aff003;  Guided Therapy Systems/Ardent Sound, Mesa, Arizona, United States of America aff004
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226001


The utility of echo decorrelation imaging feedback for real-time control of in vivo ultrasound thermal ablation was assessed in rabbit liver with VX2 tumor. High-intensity focused ultrasound (HIFU) and unfocused (bulk) ablation were performed using 5 MHz linear image-ablate arrays. Treatments comprised up to nine lower-power sonications, followed by up to nine higher-power sonications, ceasing when the average cumulative echo decorrelation within a control region of interest exceeded a predefined threshold (− 2.3, log10-scaled echo decorrelation per millisecond, corresponding to 90% specificity for tumor ablation prediction in previous in vivo experiments). This threshold was exceeded in all cases for both HIFU (N = 12) and bulk (N = 8) ablation. Controlled HIFU trials achieved a significantly higher average ablation rate compared to comparable ablation trials without image-based control, reported previously. Both controlled HIFU and bulk ablation trials required significantly less treatment time than these previous uncontrolled trials. Prediction of local liver and VX2 tumor ablation using echo decorrelation was tested using receiver operator characteristic curve analysis, showing prediction capability statistically equivalent to uncontrolled trials. Compared to uncontrolled trials, controlled trials resulted in smaller thermal ablation regions and higher contrast between echo decorrelation in treated vs. untreated regions. These results indicate that control using echo decorrelation imaging may reduce treatment duration and increase treatment reliability for in vivo thermal ablation.

Klíčová slova:

Acoustics – Cancer treatment – Echoes – Histology – In vivo imaging – Liver and spleen scan – Rabbits – Sonication


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