Health-related quality of life in patients with atrial fibrillation: The role of symptoms, comorbidities, and the type of atrial fibrillation

Autoři: Fabienne Witassek aff001;  Anne Springer aff002;  Luise Adam aff004;  Stefanie Aeschbacher aff002;  Jürg H. Beer aff005;  Steffen Blum aff002;  Leo H. Bonati aff006;  David Conen aff002;  Richard Kobza aff008;  Michael Kühne aff002;  Giorgio Moschovitis aff009;  Stefan Osswald aff002;  Nicolas Rodondi aff004;  Christian Sticherling aff002;  Thomas Szucs aff011;  Matthias Schwenkglenks aff001
Působiště autorů: Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland aff001;  Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland aff002;  Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland aff003;  Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland aff004;  Department of Medicine, Cantonal Hospital of Baden, Baden, and Molecular Cardiology, University Hospital of Zurich, Zurich, Switzerland aff005;  Neurology Division and Stroke Centre, Department of Clinical Research, University Hospital Basel, Basel, Switzerland aff006;  Population Health Research Institute, McMaster University, Hamilton, Canada aff007;  Department of Cardiology, Luzerner Kantonsspital, Lucerne, Switzerland aff008;  Division of Cardiology, Ente Ospedaliero Cantonale, Ospedale Regionale di Lugano, Ticino, Lugano, Switzerland aff009;  Institute of Primary Health Care (BIHAM), University of Bern, Berne, Switzerland aff010;  Institute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland aff011
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226730



This study aimed to analyse health related quality of life (HRQoL) for patients with different atrial fibrillation (AF) types and to identify patient characteristics, symptoms and comorbidities that influence HRQoL.


We used baseline data from the Swiss Atrial Fibrillation (Swiss-AF) study, a prospective multicentre observational cohort study conducted in 13 clinical centres in Switzerland. Between April 2014 and August 2017, 2415 AF patients were recruited. Patients were included in this analysis if they had baseline HRQoL data as assessed with EQ-5D-based utilities and visual analogue scale (VAS) scores. Patient characteristics and HRQoL were described stratified by AF type. The impact of symptoms, comorbidities and socio-economic factors on HRQoL was analysed using multivariable regression analysis.


Based on 2412 patients with available baseline HRQoL data, the lowest unadjusted mean HRQoL was found in patients with permanent AF regardless of whether measured with utilities (paroxysmal: 0.83, persistent: 0.84, permanent: 0.80, p<0.001) or VAS score (paroxysmal: 73.6, persistent: 72.8, permanent: 69.2, p<0.001). In multivariable analysis of utilities and VAS scores, higher European Heart Rhythm Association (EHRA) score, recurrent falls and several comorbidities showed a strong negative impact on HRQoL while AF type was no longer associated with HRQoL.


Multiple factors turned out to influence HRQoL in AF patients. After controlling for several comorbidities, the EHRA score was one of the strongest predictors independent of AF type. The results may be valuable for better patient assessment and provide a reference point for further QoL and health economic analyses in AF populations.

Klíčová slova:

Arteries – Atrial fibrillation – Deep vein thrombosis – Fatigue – Heart failure – Patients – Sleep apnea


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Článek vyšel v časopise


2019 Číslo 12