Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation

Autoři: Matti Mauramo aff001;  Patricia Grolimund aff003;  Adrian Egli aff004;  Jakob Passweg aff006;  Jörg Halter aff006;  Tuomas Waltimo aff003
Působiště autorů: Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland aff001;  Department of Pathology, Haartman Institute and HUSLab, Helsinki University Central Hospital, Helsinki, Finland aff002;  Department for Oral Health & Medicine, UZB University Centre for Dental Medicine Basel, University of Basel, Basel, Switzerland aff003;  Division of Clinical Microbiology, University Hospital Basel, Basel, Switzerland aff004;  Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland aff005;  Department of Haematology, University Hospital Basel, Basel, Switzerland aff006
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225099



Haematopoietic stem cell transplantation (HSCT) recipients are at increased risk for severe infections. This study examined the associations of common oral infections with survival and infectious complications in HSCT recipients.

Materials and methods

All autologous and allogeneic HSCT recipients transplanted in the University Hospital of Basel, Switzerland, between 2008 and 2016 and referred to oral infection control pre-HSCT were included in this retrospective case-control study. All patients had a clinical and a panoramic radiological dental examination taken immediately prior to HSCT. Presence of acute or chronic oral foci of infections, decayed, missing or filled tooth index (DMFT) and radiological attachment loss (RAL) were examined. Survival and infections of the subjects were followed up for 6 months post-HSCT.


Altogether 341 allogeneic and 125 autologous HSCT recipients were included in the study. Within 6 months post-HSCT, 47 (14%) of the allogeneic and 4 (3%) of the autologous recipients died. Oral foci of infections (acute or chronic), DMFT or periodontitis pre-HSCT were not associated with survival 6 months post-HSCT. Oral foci of infections were also not associated with hospital treated infectious diseases or blood culture positive bacteremia during the 6 month follow-up period. Untreated oral foci of infections were not associated with survival or severe infectious complications within 6 months post-HSCT.


The results of this study suggest that radical dental interventions to chronic oral infections could be postponed until post-HSCT.

Klíčová slova:

Bacteremia – Blood – Cancer treatment – Caries – Hematopoietic stem cell transplantation – Oral diseases – Periodontitis – Streptococcal infections


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Článek vyšel v časopise


2019 Číslo 12