Interaction between BDNF val66met polymorphism and personality on long-term cardiac outcomes in patients with acute coronary syndrome

Autoři: Jae-Min Kim aff001;  Robert Stewart aff002;  Seon-Young Kim aff001;  Ju-Wan Kim aff001;  Hee-Ju Kang aff001;  Ju-Yeon Lee aff001;  Sung-Wan Kim aff001;  Il-Seon Shin aff001;  Min Chul Kim aff003;  Young Joon Hong aff003;  Youngkeun Ahn aff003;  Myung Ho Jeong aff003;  Jin-Sang Yoon aff001
Působiště autorů: Departments of Psychiatry, Chonnam National University Medical School, Gwangju, Korea aff001;  King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom, and South London and Maudsley NHS Foundation Trust, London, United Kingdom aff002;  Department of Cardiology, Chonnam National University Medical School, Gwangju, Korea aff003
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article



The prognostic role of BDNF val66met polymorphism on long-term cardiac outcomes in acute coronary syndrome (ACS) has been unclear. Environmental factors may modify the association, but these have not been investigated to date. This study aimed to investigate the potential interactive effects of BDNF val66met polymorphism and personality traits, one of the main environmental prognostic factors of ACS, on major adverse cardiac events (MACEs) in patients with ACS.


A total of 611 patients with recent ACS were recruited at a university hospital in Korea. Baseline evaluations from 2007 to 2012 assessed BDNF val66met polymorphism and personality using the Big Five Inventory, which yielded two personality clusters (resilient and vulnerable) and five dimensions (extraversion, agreeableness, conscientiousness, neuroticism, and openness). Over a 5~12 year follow-up after the index ACS, times to MACE were investigated using Cox regression models after adjustment for a range of covariates.


The BDNF val66met polymorphism modified the associations between vulnerable personality type and worse long-term cardiac outcomes in ACS patients with significant interaction terms, in that the associations were statistically significant in the presence met allele. Similar findings were observed for the individual personality dimensions of agreeableness and neuroticism.


Gene (BDNF val66met polymorphism) x environment (personality traits) interactions on long-term cardiac outcomes were found in ACS.

Klíčová slova:

Depression – Myocardial infarction – Patients – Personality – Personality tests – Personality traits – Prognosis – Variant genotypes


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