Omentin-1 in diabetes mellitus: A systematic review and meta-analysis


Autoři: Xiongfeng Pan aff001;  Atipatsa C. Kaminga aff001;  Shi Wu Wen aff001;  Kwabena Acheampong aff001;  Aizhong Liu aff001
Působiště autorů: Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China aff001;  Department of Mathematics and Statistics, Mzuzu University, Mzuzu, Malawi aff002;  Department of Obstetrics and Gynaecology and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada aff003;  Department of Public, School of Postgraduate Studies, Adventist University of Africa, Nairobi, Kenya aff004
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226292

Souhrn

Objective

Previous studies found inconsistent results on the relationship between diabetes mellitus and concentrations of omentin-1. This study performed a systematic review and meta-analysis to summarize previous findings on this relationship.

Methods

Studies related to this outcome were obtained using a systematic search in the electronic databases of Cochrane Library, PubMed, Embase, SCOPUS, Google Scholar, gray literature and Web of Science in September 2019. The random effects model was used to measure the strength of the association between diabetes mellitus and concentrations of omentin-1, using standardized mean difference.

Results

Forty-two eligible studies were included in the final meta-analysis. There was no significant difference in omentin-1 concentration between patients with type 1 diabetes mellitus and the controls. On the other hand, lower concentration levels of omentin-1 were observed in patients with gestational diabetes mellitus (standardized mean difference:-0.44, 95% confidence interval:-0.76; -0.12, p = 0.007), or type 2 diabetes mellitus (standardized mean difference: -1.74, 95% confidence interval: -2.31; -1.16, p< 0.001) than in the controls.

Conclusion

Decreased omentin-1 concentrations may be an important indicator for gestational diabetes mellitus and type 2 diabetes mellitus. More studies are needed to validate this hypothesis and evaluate the role of omentin-1 concentrations in type 1 diabetes mellitus.

Klíčová slova:

Database searching – Enzyme-linked immunoassays – Insulin – Systematic reviews


Zdroje

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