Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip

Autoři: Lihua Qin aff001;  Kyung J. Ahn aff001;  Lara Wine Lee aff001;  Charles de Charleroy, Jr aff001;  E. Bryan Crenshaw, III aff001
Působiště autorů: Division of Pediatric Otolaryngology, Mammalian Neurogenetics Group, Center for Childhood Communication, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America aff001;  Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China aff002;  Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America aff003;  Department of Otorhinolaryngology, Head and Neck Surgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America aff004
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226602


Bone morphogenetic proteins (BMPs) have been hypothesized to specify distinct dorsal neural fates. During neural development, BMPs are expressed in the roof plate and adjacent neuroepithelium. Because several hindbrain nuclei that form the proprioceptive/vestibular/auditory sensory network originate from the rhombic lip, near the roof plate, BMP signaling may regulate the development of these nuclei. To test this hypothesis genetically, we have examined the development of the hindbrain in BMP type I receptor knockout mice. Our results demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei, which give rise to cerebellar mossy fibers, but is not required for the development of the inferior olivary nucleus, which gives rise to cerebellar climbing fibers.

Klíčová slova:

Auditory pathway – BMP signaling – Cerebellum – Gene expression – Nerve fibers – Neurons – Hindbrain – Climbing fibers


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