The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder

Autoři: Lindsay C. Hanford aff001;  Kristen Eckstrand aff001;  Anna Manelis aff001;  Danella M. Hafeman aff001;  John Merranko aff001;  Cecile D. Ladouceur aff001;  Simona Graur aff001;  Alicia McCaffrey aff001;  Kelly Monk aff001;  Lisa K. Bonar aff001;  Mary Beth Hickey aff001;  Tina R. Goldstein aff001;  Benjamin I. Goldstein aff002;  David Axelson aff004;  Genna Bebko aff001;  Michele A. Bertocci aff001;  Mary Kay Gill aff001;  Boris Birmaher aff001;  Mary L. Phillips aff001
Působiště autorů: Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America aff001;  Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Canada aff002;  Pharmacology and Toxicology, University of Toronto, Toronto, Canada aff003;  Nationwide Children’s Hospital and The Ohio State College of Medicine, Columbus, Ohio, United States of America aff004
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226135


A recently developed risk calculator for bipolar disorder (BD) accounts for clinical and parental psychopathology. Yet, it is understood that both familial predisposition and early life adversity contribute to the development of BD. How the interplay between these two factors influence emotion and reward processing networks in youth at risk for BD remains unclear. In this exploratory analysis, offspring of BD parents performed emotion and reward processing tasks while undergoing a fMRI scan. Risk calculator score was used to assess risk for developing BD in the next 5 years. Environmental risk was tabulated using the Stressful Life Events Schedule (SLES). Emotion and reward processing networks were investigated for genetic and/or environment interactions. Interaction effects were found between risk calculator scores, negative SLES score and activity in right amygdala and bilateral fusiform gyri during the emotion processing task, as well as activity in the fronto-, striatal, and parietal regions during the reward processing task. Our findings are preliminary; however, they support the unique and interactive contributions of both familial and environmental risk factors on emotion and reward processing within OBP. They also identify potential neural targets to guide development of interventions for youth at greatest risk for psychiatric disorders.

Klíčová slova:

Bipolar disorder – Emotions – Environmental impacts – Genetic networks – Mental health and psychiatry – Occipital lobe – Psychological stress – Amygdala


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