Length of gestation and birth weight are associated with indices of combined kidney biomarkers in early childhood

Autoři: Yuri Levin-Schwartz aff001;  Paul Curtin aff001;  Katherine Svensson aff001;  Nicolas F. Fernandez aff002;  Seunghee Kim-Schulze aff002;  Gleicy M. Hair aff001;  Daniel Flores aff004;  Ivan Pantic aff005;  Marcela Tamayo-Ortiz aff005;  María Luisa Pizano-Zárate aff008;  Chris Gennings aff001;  Lisa M. Satlin aff004;  Andrea A. Baccarelli aff009;  Martha M. Téllez-Rojo aff005;  Robert O. Wright aff001;  Alison P. Sanders aff001
Působiště autorů: Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America aff001;  Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America aff002;  Department of Oncological Science, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America aff003;  Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America aff004;  Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico aff005;  Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico aff006;  National Council of Science and Technology, Mexico City, Mexico aff007;  Division of Community Interventions Research, National Institute of Perinatology, Mexico City, Mexico aff008;  Department of Environmental Health Sciences, Columbia University, New York, NY, United States of America aff009
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0227219


Infants born prematurely or with low birth weights are more susceptible to kidney dysfunction throughout their lives. Multiple proteins measured in urine are noninvasive biomarkers of subclinical kidney damage, but few studies have examined the joint effects of multiple biomarkers. We conducted an exploratory study of 103 children in the Programing Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) longitudinal birth cohort, and measured nine proteins selected a priori in banked spot urine samples collected at ages 4–6. The goal of our study was to explore the combined effects of kidney damage biomarkers previously associated with birth outcomes. To do this, we generated kidney biomarker indices using weighted quantile sum regression and assessed associations with length of gestation or birth weight. A decile increase in each kidney biomarker index was associated with 2-day shorter gestations (β = -2.0, 95% CI: -3.2, -0.9) and 59-gram lower birth weights (β = -58.5, 95% CI: -98.3, -18.7), respectively. Weights highlighting the contributions showed neutrophil gelatinase-associated lipocalin (NGAL) (60%) and osteopontin (19%) contributed most to the index derived for gestational age. NGAL (66%) and beta-2-microglobulin (10%) contributed most to the index derived for birth weight. Joint analyses of multiple kidney biomarkers can provide integrated measures of kidney dysfunction and improved statistical assessments compared to biomarkers assessed individually. Additionally, shorter gestations and lower birth weights may contribute to subclinical kidney damage measurable in childhood.

Klíčová slova:

Albumins – Biomarkers – Birth weight – Creatinine – Infants – Kidneys – Preterm birth – Urine


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